The effects of hormone replacement therapy combined with vitamins C and E on antioxidants levels and lipid profiles in postmenopausal women with Type 2 diabetes

Nazıroğlu, Mustafa; Şi̇mşek, Mehmet; Şimşek, Halil; Aydılek, Nurettın; Özcan, Zeynep; Atılgan, Remzi

doi:10.1016/j.cccn.2004.01.031

Cited by 59 publications

(54 citation statements)

References 27 publications

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“…10 ). Vitamin E supplementation affects plasma total cholesterol and LDL-and VLDL-cholesterol levels and one can hypothesize that the antioxidant power of it could preserve LDL-cholesterol from the peroxidation phenomenon ( 11 ). There is also some evidence that a poorly digested fat such as olestra can potentially decrease the absorption of fat-soluble vitamins such as vitamins A and E ( 7 , 8 ).…”

mentioning

confidence: 99%

Dietary Hydrogenated Soybean Oil Affects Lipid and Vitamin E Metabolism in Rats

Nazıroğlu

Brandsch

2006

J Nutr Sci Vitaminol

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Summary Fatty acids containing stearic acid, which are found in hydrogenated fat, may have a detrimental effect on the cholesterol and triacylglycerol (TAG) content of plasma lipoproteins, and on the absorption of fatty acids and fat-soluble vitamins. The aim of our study was to examine the tissue concentration of lipids and vitamins A and E after feeding a hydrogenated soybean oil (HSO) diet to rats. Twenty male Sprague-Dawley rats were randomly divided into two groups, fed on coconut oil (control) and HSO, respectively in amounts corresponding to 15% of the total feed. Plasma total cholesterol, VLDL-and LDLcholesterol, lipid peroxidation and daily excretion of the TAG and cholesterol in feces were higher in the HSO than in the control group. TAG values in plasma and liver, and HDL-cholesterol levels in plasma were lower in the HSO than in the control group. The same was true for phospholipids in plasma and for saturated fatty acids, mono-and polyunsaturated fatty acids levels in the liver and vitamin E in plasma, LDL and adipose tissue. The results of this study provide new evidence concerning the effect of dietary hydrogenated fat on lipid, TAG and vitamin E status, which are important for maintenance of good health. Consumption of dietary HSO may be associated with cardiovascular disease.

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confidence: 99%

Dietary Hydrogenated Soybean Oil Affects Lipid and Vitamin E Metabolism in Rats

Nazıroğlu

Brandsch

2006

J Nutr Sci Vitaminol

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“…[18] The VCE supplemented diet contained a combination of one g vitamin C (ascorbic acid) and 600 mg vitamin E (di-α-tocopheryl acetate)/kg food. [16] Group design: Animals were classified into 4 main groups: Negative Control group (Group 1): included 10 rats fed on standard diet consisted of 53% carbohydrates in the form of sucrose sugar, 20% protein in the form of casine, 6% fat in the form of butter and 21% water. [19] Positive control group (Group 2): included 10 rats fed on standard diet and were given intra peritoneal citrate buffer only (0.1 M, pH = 4.5).…”

Section: Methodsmentioning

confidence: 99%

“…[18] Experimental diabetic group (Group 3): included 10 rats fed on standard diet and given single dose of STZ intraperitoneally at a dose of 40 mg/kg body weight dissolved in citrate buffer. [16] Serum levels of fasting blood glucose were measured, using a one-touch basic plus glucometer to all rats 2 weeks after the injection of STZ to confirm diabetes, and the glucose levels starting from 150 mg/dl and higher were considered diabetic. [20] The possible protected or prophylactic group (Group 4) :Included 10 rats.…”

Section: Methodsmentioning

confidence: 99%

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Effect of Diabetes on the Rat Renal Cortex and the Possible Protective Role of Vitamins C and E

Ali¹,

Hulail²,

Hegazy³

et al. 2017

AIMDR

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“…It has also been suggested that cisplatin is able to generate reactive oxygen species by inducing glucose-6-phosphate dehydrogenase and hexokinase activity and inhibit the activity of antioxidant enzyme in tissue such as SOD, CAT, and GSH-Px [62].…”

Section: The Biochemical Effectsmentioning

confidence: 99%

Cisplatin-Induced Ovarian Cytotoxicity and the Modulating Role of Aqueous Zest Extract of Citrus limonium (AZECL) in Rat Models

Gg¹,

Oa²,

Uk³

et al. 2017

J Tradi Med Clin Natur

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Cisplatin is a prominent member of the effective broad-spectrum antitumor drugs. However, its clinical usage is restricted due to some adverse side effects, such as testiculototoxicity, hepatotoxicity and nephrotoxicity. The aim of this study is to evaluate the effect of Aqueous Zest Extract of Citrus limonium (AZECL) on the ovary of female Wistar rat treated with Cisplatin. Twenty adult female Wistar rats were divided into four groups (A-D) containing five rats each. Group A rats served as negative control and were treated orally with 2.5 ml/kg body weight of normal saline, group B rats served as positive control group and were treated intraperitoneally with a single dose of 10 mg/kg body weight of Cisplatin, group C rats were treated orally with 50 mg/kg body weight of AZECL and group D rats were treated intraperitoneally with a single dose of 10 mg/kg body weight of Cisplatin and two weeks later treated orally with 50 mg/kg body weight of AZECL. Result showed a significant (p<0.01) decrease in primary follicles, secondary follicles, graafian follicles and a significant (p<0.01) increase in atretic follicles, PAS positive reaction and reduction in the total carbohydrate contents of the stromal cells in the positive control group. Also there was a significant (p<0.05) decrease in the activity level of FSH, LH and a significant (p<0.05) increase in Malondialdehyde when compared to rats in group A and C. The group post-treated with the extract had remarkable normalization of the histo-morphometric, histochemical and biochemical parameters when compared to the positive control group. Aqueous zests extract of C. limonium has a curative effect on cisplatin-induced cytotoxicity on the ovary.

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The effects of hormone replacement therapy combined with vitamins C and E on antioxidants levels and lipid profiles in postmenopausal women with Type 2 diabetes

Cited by 59 publications

References 27 publications

Dietary Hydrogenated Soybean Oil Affects Lipid and Vitamin E Metabolism in Rats

Dietary Hydrogenated Soybean Oil Affects Lipid and Vitamin E Metabolism in Rats

Effect of Diabetes on the Rat Renal Cortex and the Possible Protective Role of Vitamins C and E

Cisplatin-Induced Ovarian Cytotoxicity and the Modulating Role of Aqueous Zest Extract of Citrus limonium (AZECL) in Rat Models

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