The effects of histamine and an antihistamine on Trichinella spiralis and on trichinous enteritis in the host

Stewart, G. W.; Kramar, Gary W.; Charniga, Larry; Kramar, Marsha

doi:10.1016/0020-7519(85)90071-2

Cited by 7 publications

(1 citation statement)

References 29 publications

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“…1989), chlamydamona (Hirschberg & Hutchinson 1980; Detmers & Condeelis 1986; Schuring et al . 1990), trichinella (Stewart et al . 1985), trypanosomes (Chang & Pechere 1989; Loiseau et al .…”

Section: Introductionmentioning

confidence: 99%

Phenothiazines: potential alternatives for the management of antibiotic resistant infections of tuberculosis and malaria in developing countries

Amaral

Viveiros

Kristiansen

2001

Tropical Med Int Health

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SummaryThe in vitro and in vivo activity of phenothiazines against antibiotic susceptible and antibiotic resistant Mycobacterium tuberculosis and malaria-causing Plasmodia is reviewed. Given the facts that pulmonary tuberculosis and malaria are the major causes of death in developing countries, that both of these infections continue to escalate in their resistance to antibiotics, that the cost for the management of these infections is beyond that afforded by most developing nations, and lastly, that new and effective agents are not forthcoming from the pharmaceutical industry, the scienti®c rationale for the potential use of select phenothiazines for the management of these infections is presented.keywords phenothiazines, antimicrobial activity, tuberculosis, malaria correspondence Professor Leonard Amaral,

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Section: Introductionmentioning

confidence: 99%

Phenothiazines: potential alternatives for the management of antibiotic resistant infections of tuberculosis and malaria in developing countries

Amaral

Viveiros

Kristiansen

2001

Tropical Med Int Health

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Distribution of histamine in the lumen contents of the small intestine of uninfected andHymenolepis diminuta-infected rats

Yonge

Webb

1989

Parasitol Res

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Using a specific radioenzymatic assay, histamine was detected and measured in the lumen contents of six different segments of the small intestine of uninfected rats and rats infected with Hymenolepis diminuta as well as in worm tissues. The distribution of histamine in the lumen of the small intestine of uninfected rats was found to range from 1.4 +/- 0.1 microM in the first (anterior) segment to 0.59 +/- 0.13 mM in the sixth (posterior) segment. There were no significant differences between these concentrations and those found in the lumen contents of intestine from rats infected with H. diminuta. On the other hand, although most H. diminuta was confined to the second and third segments, the concentration of histamine associated with the worm tissues (5.4 +/- 0.4 microM) was significantly lower than that in Hymenolepis-containing intestinal segments. The data suggest that established infections of H. diminuta do not cause a significant increase in histamine levels in host's intestinal lumen, nor do they affect the spatial gradient in the lumen.

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IgE and Immune Defense Mechanism

Dessaint

Càpron

1989

Clinical Reviews in Allergy

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The effects of histamine and an antihistamine on Trichinella spiralis and on trichinous enteritis in the host

Cited by 7 publications

References 29 publications

Phenothiazines: potential alternatives for the management of antibiotic resistant infections of tuberculosis and malaria in developing countries

Phenothiazines: potential alternatives for the management of antibiotic resistant infections of tuberculosis and malaria in developing countries

Distribution of histamine in the lumen contents of the small intestine of uninfected andHymenolepis diminuta-infected rats

IgE and Immune Defense Mechanism

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