The effects of HIIT compared to MICT on endothelial function and hemodynamics in postmenopausal females

He, Hongqing; Wang, Chenghao; Chen, Xiaoke; Sun, Xinzheng; Wang, Yao; Yang, Jiani; Wang, Fatao

doi:10.1016/j.jsams.2022.01.007

Cited by 11 publications

(8 citation statements)

References 28 publications

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“…The decrease in FMD in response to exercise training may seem unexpected since the opposite effect has been reported from early studies on training-induced changes in endothelial function 29 . The recent available data also show improved FMD after the training intervention both in healthy 22,[30][31][32] and diseased subjects 33,34 . Additionally, some of these studies revealed that the high intensity interval training regimen (HIIT) is more effective in increasing FMD than moderate intensity continuous training (MICT) [30][31][32] .…”

Section: Fmd Responses To Trainingmentioning

confidence: 82%

“…The recent available data also show improved FMD after the training intervention both in healthy 22,[30][31][32] and diseased subjects 33,34 . Additionally, some of these studies revealed that the high intensity interval training regimen (HIIT) is more effective in increasing FMD than moderate intensity continuous training (MICT) [30][31][32] . Such conclusion was also drawn in the meta-analysis by Ramos et al 35 who reported that HIIT is It has to be stressed out that professional training program performed by athletes at national level differs drastically from HIIT regimens used in experimental studies.…”

Section: Fmd Responses To Trainingmentioning

confidence: 82%

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Training-induced impairment of endothelial function in track and field female athletes

Grandys

Majerczak

Frołow

et al. 2023

Sci Rep

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Professional athletes are often exposed to high training loads that may lead to overfatigue, overreaching and overtraining that might have a detrimental effects on vascular health. We determined the effects of high training stress on endothelial function assessed by the flow-mediated dilation (FMD) and markers of glycocalyx shedding. Vascular examination as well as broad biochemical, hormonal and cardiometabolic evaluation of sprint and middle-distance female runners were performed after 2 months of preparatory training period and compared to age-matched control group of women. Female athletes presented with significantly reduced FMD (p < 0.01) and higher basal serum concentrations of hyaluronan (HA) and syndecan-1 (SDC-1) (p < 0.05 and p < 0.001, respectively), that was accompanied by significantly lower basal serum testosterone (T) and free testosterone (fT) concentrations (p < 0.05) and higher cortisol (C) concentration (p < 0.05). It resulted in significantly lower T/C and fT/C ratios in athletes when compared to controls (p < 0.01). Moreover, fT/C ratio were significantly positively correlated to FMD and negatively to HA concentrations in all studied women. Accordingly, the training load was significantly negatively correlated with T/C, fT/C and FMD and positively with the concentrations of HA and SDC-1. We concluded that young female track and field athletes subjected to physical training developed impairment of endothelial function that was associated with anabolic-catabolic hormone balance disturbances. Given that training-induced impairment of endothelial function may have a detrimental effects on vascular health, endothelial status should be regularly monitored in the time-course of training process to minimalize vascular health-risk in athletes.

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Section: Fmd Responses To Trainingmentioning

confidence: 82%

Section: Fmd Responses To Trainingmentioning

confidence: 82%

Training-induced impairment of endothelial function in track and field female athletes

Grandys

Majerczak

Frołow

et al. 2023

Sci Rep

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“…Only one study directly compared low‐ and moderate‐intensity exercise, finding that neither walking protocol improved FMD (Tudor‐Locke et al., 2020). Two studies published following our search also investigated the impact of training intensity on macrovascular endothelial function, with one finding no impact of 12 weeks of either high‐ or moderate‐intensity interval training on FMD (Lyall et al., 2022) and one finding significant improvements in FMD following 12 weeks of continuous low‐intensity training and 8 weeks of moderate‐intensity continuous training and HIIT (He et al., 2022). Taken together, low‐, moderate‐ and high‐intensity training did not appear to elicit consistent improvements in FMD across studies, contrary to the significant positive relationship between training intensity and endothelial function previously reported (Ashor et al., 2015).…”

Section: Discussionmentioning

confidence: 99%

The impact of exercise training on endothelial function in postmenopausal women: a systematic review

Lew

Ethier

Pyke

2022

Experimental Physiology

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New Findings What is the topic of this review?The aim of this systematic review was to evaluate and summarize all published literature examining the impact of various exercise training interventions on endothelial function in postmenopausal women. What advances does it highlight?There was a moderate effect of training on macrovascular and microvascular endothelial function and just under two‐thirds of studies demonstrated a significant increase in at least one measure of endothelial function in postmenopausal women. Factors including exercise intensity and duration, vessel type, clinical status, hormone therapy, and menopausal status may influence the effects of training on endothelial function in postmenopausal women. Abstract Women experience a rapid decline in endothelial function during menopause. Therefore, it is important to explore interventions, such as exercise training, that may prevent endothelial dysfunction in postmenopausal women. The aim of this systematic review was to evaluate and summarize all published literature examining the impact of various exercise training interventions on endothelial function in postmenopausal women. Three electronic databases (MEDLINE, EMBASE and Web of Science) were used to systematically select studies related to exercise training, endothelial function and postmenopausal women. The major initial and secondary update systematic searches yielded 502 unique articles that were screened for eligibility. Thirty‐five studies were included in the systematic review. Two‐thirds of all studies demonstrated a group‐level increase in at least one measure of endothelial function with training. Most studies investigating biomarkers of endothelial function showed improvement in at least one measured biomarker post‐training. There was a moderate effect of training on both macrovascular and microvascular endothelial function in observational and randomized intervention studies. Variability in study designs, training protocols and participant characteristics make it difficult to directly compare studies. Factors including exercise intensity and duration, vessel type, clinical status, hormone therapy, and menopausal status may contribute to the inconsistent effects of training on endothelial function in postmenopausal women. Future research is needed in this population to understand the mechanisms driving inter‐study and inter‐individual differences in training‐induced changes in endothelial function.

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“…While both interventions improved endothelial function, HIIT was particularly effective at enhancing flow-mediated dilation as well as vasoconstrictive and vasodilatory responses. These results allowed the authors to classify HIIT as a feasible training protocol for improving endothelial function among postmenopausal women [ 141 ]. Another study investigated the effects of HIIT on the inflammatory and adipokine profile in postmenopausal women with MetS before and after a 12-week training period.…”

Section: Exercise Improves Metabolic Health Following the Menopausementioning

confidence: 99%

Adipocyte Metabolism and Health after the Menopause: The Role of Exercise

2023

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Postmenopausal women represent an important target population in need of preventative cardiometabolic approaches. The loss of estrogen following the menopause eliminates protections against metabolic dysfunction, largely due to its role in the health and function of adipose tissue. In addition, some studies associate the menopause with reduced physical activity, which could potentially exacerbate the deleterious cardiometabolic risk profile accompanying the menopause. Meanwhile, exercise has adipocyte-specific effects that may alleviate the adverse impact of estrogen loss through the menopausal transition period and beyond. Exercise thus remains the best therapeutic agent available to mitigate menopause-associated metabolic dysfunction and represents a vital behavioral strategy to prevent and alleviate health decline in this population.

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The effects of HIIT compared to MICT on endothelial function and hemodynamics in postmenopausal females

Cited by 11 publications

References 28 publications

Training-induced impairment of endothelial function in track and field female athletes

Training-induced impairment of endothelial function in track and field female athletes

The impact of exercise training on endothelial function in postmenopausal women: a systematic review

Adipocyte Metabolism and Health after the Menopause: The Role of Exercise

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