The effects of high perioperative inspiratory oxygen fraction for adult surgical patients

Wetterslev, Jørn; Meyhoff, Christian S.; Jørgensen, Lars Nannestad; Gluud, Christian; Lindschou, Jane; Rasmussen, Lars S.

doi:10.1002/14651858.cd008884.pub2

Cited by 98 publications

(95 citation statements)

References 127 publications

(11 reference statements)

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“…There is a separate body of evidence, mostly in the elective surgical setting 18. There is an unresolved debate about whether supplemental oxygen reduces the risk of surgical site infections.…”

Section: Understanding the Recommendationsmentioning

confidence: 99%

Oxygen therapy for acutely ill medical patients: a clinical practice guideline

Siemieniuk

Chu

Kim

et al. 2018

BMJ

212

162

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Section: Understanding the Recommendationsmentioning

confidence: 99%

Oxygen therapy for acutely ill medical patients: a clinical practice guideline

Siemieniuk

Chu

Kim

et al. 2018

BMJ

212

162

View full text Add to dashboard Cite

“…This positive outcome corresponds to the Cochrane review of Wetterslev et al 88 Here, they also concluded that high supplemental inspired oxygen during colorectal and abdominal surgery decreases the risk of SSIs. 88 However, a large trial of Meyhoff et al, that investigated high-inspired oxygen during abdominal surgery showed no differences in SSIs rates between patients receiving 30 and 80% oxygen. 89 Although this randomized clinical trial included a great amount of various types of abdominal surgical procedures, they did not investigate the risk of SSI for every surgical procedure separately.…”

Section: Supplemental Inspired Oxygenmentioning

confidence: 99%

Oxygen therapies and their effects on wound healing

Smet

Kroese

Menon

et al. 2017

Wound Repair Regeneration

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Oxygen is an important factor for wound healing. Although several different therapies investigated the use of oxygen to aid wound healing, the results of these studies are not unequivocal. This systematic review summarizes the clinical and experimental studies regarding different oxygen therapies for promoting wound healing, and evaluates the outcomes according the methodological details. A systematic literature search was conducted using Embase, Medline, Web of Science, Cochrane, PubMed publisher, and Google Scholar libraries. Clinical and experimental studies investigating oxygen for wound healing were selected. Included articles were categorized according to the kind of therapy, study design, and wound type. The methodological details were extracted and analyzed. Sixty-five articles were identified and divided in three different oxygen therapies: Local oxygen therapy, hyperbaric oxygen therapy, and supplemental inspired oxygen therapy. More than half of the included local oxygen and hyperbaric oxygen studies had one or more significant positive outcomes, 77 and 63%, respectively. Supplemental inspired oxygen therapy during gastrointestinal and vascular surgery was more likely to have a positive result than during other surgical interventions reducing surgical site infections. These many positive outcomes promote the use of oxygen treatment in the stimulation of wound healing. However, the lack of clinical studies and vast methodological diversity made it impossible to perform a proper comparison within and between the different therapies. Further randomized clinical studies are warranted to examine the value of these therapies, especially studies that investigate the more patient-friendly oxygen dressings and topical wound oxygen therapies. Also, to achieve more solid and consistent data, studies should use more standardized methods and subjects.

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“…1,2 Only recently, perioperative hyperoxia has been associated with higher patient mortality and morbidity although the detailed injurious mechanisms remain unknown. [3][4][5][6] While the effects of constant hyperoxia on the human body have been investigated to some extent, little is known with regard to cyclic hyperoxia that may occur during O 2 -administration in the presence of altered cardiac or pulmonary function. For example, cyclic hyperoxia can be caused by cyclic recruitment and derecruitment of lung atelectasis (cyclic atelectasis, CA) during high-dose O 2 -administration.…”

Section: Editorial Comment: What This Article Tells Usmentioning

confidence: 99%

“…39 However, recent studies have questioned a net beneficial effect of hyperoxia that seems associated with increased mortality and morbidity. [4][5][6] The mechanisms by which hyperoxia may harm the human body include increase in reactive O 2 -species, reduced organ blood flow, and disturbances in cellular redox balance. 1,2 The present study adds a novel concept to this topic by proposing that extreme constant and cyclic hyperoxia potentially may cause harm to the vascular endothelium by signaling pathways including the oxidative stress, NFjB, Notch, and PPAR pathway.…”

Section: Clinical Relevancementioning

confidence: 99%