The effects of high-frequency transcranial random noise stimulation (hf-tRNS) on global motion processing: An equivalent noise approach

Ghin, Filippo; Pavan, Andrea; Contillo, Adriano; Mather, George

doi:10.1016/j.brs.2018.07.048

Cited by 28 publications

(38 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Corticospinal excitability was assessed by measuring the amplitude of MEPs of the first dorsal interosseous (FDI) by TMS over M1 using a Magstim Rapid 2 stimulator.…”

Section: Methodsmentioning

confidence: 99%

“…The modulatory effects of tRNS – mainly involving the high-frequency band – have been probed with different motor, sensory and cognitive tasks. Studies on sensory or perceptual processing showed, for example, that hf-tRNS can improve visual detection or discrimination 2–4 and can enhance the perception of facial identity 5 and facial expression of emotions 6,7 . Visual motion adaptation, on the other hand, has shown to be either attenuated or enhanced depending on the frequency band used 8 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Transcranial random noise stimulation (tRNS): a wide range of frequencies is needed for increasing cortical excitability

Moret

Donato

Nucci

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Transcranial random noise stimulation (tRNS) is a recent neuromodulation protocol. The high-frequency band (hf-tRNS) has shown to be the most effective in enhancing neural excitability. The frequency band of hf-tRNS typically spans from 100 to 640 Hz. Here we asked whether both the lower and the higher half of the high-frequency band are needed for increasing neural excitability. Three frequency ranges (100–400 Hz, 400–700 Hz, 100–700 Hz) and Sham conditions were delivered for 10 minutes at an intensity of 1.5 mA over the primary motor cortex (M1). Single-pulse transcranial magnetic stimulation (TMS) was delivered over the same area at baseline, 0, 10, 20, 30, 45 and 60 minutes after stimulation, while motor evoked potentials (MEPs) were recorded to evaluate changes in cortical excitability. Only the full-band condition (100–700 Hz) was able to modulate excitability by enhancing MEPs at 10 and 20 minutes after stimulation: neither the higher nor the lower sub-range of the high-frequency band significantly modulated cortical excitability. These results show that the efficacy of tRNS is strictly related to the width of the selected frequency range.

show abstract

“…Corticospinal excitability was assessed by measuring the amplitude of MEPs of the first dorsal interosseous (FDI) by TMS over M1 using a Magstim Rapid 2 stimulator.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Transcranial random noise stimulation (tRNS): a wide range of frequencies is needed for increasing cortical excitability

Moret

Donato

Nucci

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…For example, the detection of low-contrast visual stimuli was significantly enhanced when the stimuli were superimposed with visual noise (Simonotto et al 1997). Recently, a similar enhancement of visual perception has been reported when noise was directly added to visual cortex via tRNS, which improved the detection of low contrast visual stimuli (van der Groen and Wenderoth 2016), visual decision making (Ghin et al 2018;Pavan et al 2019;van der Groen et al 2019), binocular rivalry (van der Groen et al 2018), and visual training in healthy participants (Fertonani et al 2011;Pirulli et al 2013) and patients (Moret et al 2018;Herpich et al 2019).…”

Section: Introductionmentioning

confidence: 64%

“…similar to the no noise condition) is currently unknown. Possible mechanisms might be that high intensity tRNS perturbs the sampling or processing of sensory information (Ghin et al 2018;Pavan et al 2019), the "sharpness" of neural representations of the external stimulus or the process of evidence accumulation (van der Groen et al 2018), which are part of perceptual decision making. Accordingly, high tRNS intensities might cause "false alarms".…”

Section: Acute Trns-induced Noise Benefits Are Partly Consistent Withmentioning

confidence: 99%

Transcranial Random Noise Stimulation acutely lowers the response threshold of human motor circuits

Potok

Bächinger

Cretu

et al. 2020

Preprint

View full text Add to dashboard Cite

SummaryTranscranial random noise stimulation (tRNS) over cortical areas has been shown to acutely improve performance in sensory detection tasks. One explanation for this behavioural effect is stochastic resonance, a mechanism that explains how signal processing in non-linear systems can benefit from added noise. While acute noise benefits of electrical random noise stimulation have been demonstrated at the behavioural level as well as in in vitro preparations of neural tissue, it is currently largely unknown whether similar effects can be shown at the neural population level using neurophysiological readouts of human cortex. Here we hypothesized that acute tRNS will increase the responsiveness of primary motor cortex (M1) when probed with transcranial magnetic stimulation. Neural responsiveness was operationalized via the well-known concept of the resting motor threshold (RMT). We showed that tRNS acutely decreases RMT. This effect was relatively small, but it was consistently replicated across four experiments including different cohorts (total N=81), two tRNS electrode montages, and different control conditions. Our experiments provide critical neurophysiological evidence that tRNS can acutely generate noise benefits by enhancing the neural population response of human M1. These new findings complement previous behavioural research which proposed that noise induced via tRNS can beneficially modulate neural processing.

show abstract

“…There has been a burgeoning growth in recent years of studies investigating the application of tRNS to enhance sensory processing (Ghin et al, 2018;K. S. Rufener et al, 2018;Contemori et al, 2019), motor performance (Abe et al, 2019;Jooss et al, 2019), and cognition (Snowball et al, 2013;Popescu et al, 2016;Mammarella et al, 2017;Shalev et al, 2018;Tyler et al, 2018) in healthy participants with largely promising results.…”

Section: Introductionmentioning

confidence: 99%

Transcranial random noise stimulation for the acute treatment of depression: a randomized controlled trial

Nikolin

Alonzo

Martin

et al. 2019

Preprint

View full text Add to dashboard Cite

Background Transcranial electrical stimulation has broad potential as a treatment for depression. Transcranial random noise stimulation (tRNS), which delivers randomly fluctuating current intensities, may have greater cortical excitatory effects compared to other forms of transcranial electrical stimulation. We therefore aimed to investigate the antidepressant efficacy of tRNS. Methods Depressed participants were randomly assigned by computer number generator to receive 20 sessions of either active or sham tRNS over four weeks in a double-blinded, parallel group randomized-controlled trial. tRNS was delivered for 30mins with a direct current offset of 2mA and a random noise range of 2mA. Primary analyses assessed changes in depression severity using the Montgomery-Asperg Depression Rating Scale (MADRS). Neuroplasticity, neuropsychological, and safety outcomes were analysed as secondary measures. Results 69 participants were randomised, of which three discontinued treatment early leaving 66 (sham n = 34, active n = 32) for per-protocol analysis. Depression severity scores reduced in both groups (MADRS reduction in sham = 7.0 [95%CI 5.0-8.9]; and active = 5.2 [95%CI 3.2-7.3]). However, there were no differences between active and sham groups in the reduction of depressive symptoms, or the number of participants meeting response (sham = 14.7%; active = 3.1%) and remission criteria (sham = 5.9%; active = 0%). Erythema, paraesthesia, fatigue, and dizziness/light-headedness occurred more frequently in the active tRNS group. Neuroplasticity, neuropsychological and acute cognitive effects were comparable between groups. Conclusion Our results do not support the use of tRNS with the current stimulation parameters as a therapeutic intervention for the treatment of depression. Clinical trial registration at clinicaltrials.gov/NCT01792414.

show abstract

The effects of high-frequency transcranial random noise stimulation (hf-tRNS) on global motion processing: An equivalent noise approach

Abstract: hf-tRNS interacts with the output neurons tuned to directions near to the directional signal, incrementing the signal-to-noise ratio and the pooling of local motion cues and thus increasing the sensitivity for global moving stimuli.

Cited by 28 publications

References 64 publications

Transcranial random noise stimulation (tRNS): a wide range of frequencies is needed for increasing cortical excitability

Transcranial random noise stimulation (tRNS): a wide range of frequencies is needed for increasing cortical excitability

Transcranial Random Noise Stimulation acutely lowers the response threshold of human motor circuits

Transcranial random noise stimulation for the acute treatment of depression: a randomized controlled trial

Contact Info

Product

Resources

About