The effects of high-dose radiation therapy on bone: a scoping review
Lawrence Berk
Abstract:Purpose: This scoping review presents the preclinical and clinical data on the effects of high-dose radiation therapy (RT) on bone structure and function. Materials and Methods: An extensive PubMed search was performed for the relevant questions. The data were then synthesized into a comprehensive summary of the available relevant in-vitro, preclinical and clinical literature. Results: In-vitro studies of high-dose RT on cell cultures show considerable damage in the viability and functional capacity of the pri… Show more
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