The Effects of Helicobacter Pylori Eradication on the Number of Tender Points, Sleep Quality, Depression, and Anxiety in Patients With Fibromyalgia

Gezici, Emrullah; Alpaycı, Mahmut; Özkan, Yasemin; Küçük, Mehmet Emin; Ünver, Hakan; Hiz, Ozcan

doi:10.5606/archrheumatol.2014.3983

Cited by 4 publications

(11 citation statements)

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“…A total of 618 subjects with fibromyalgia (90% female [n = 554]), and 635 controls, of whom 180 (29%) had other health conditions were included. Two papers presented Eight papers evaluated markers for specific gut microbes: five reported on Helicobacter pylori [19][20][21][22][23], and are reported as a group. Four described biomarkers of the gut microbiota [18,19,26,27]; four explored metagenomics/metabolites or metabolomics [24][25][26][27], and three [17][18][19] reported other biomarkers, such as intestinal permeability.…”

Section: Resultsmentioning

confidence: 99%

Determining the association between fibromyalgia, the gut microbiome and its biomarkers: A systematic review

Erdrich

Hawrelak

Myers

et al. 2020

BMC Musculoskelet Disord

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Background: The association between fibromyalgia and irritable bowel syndrome is well-established. Alterations in the composition and diversity of the gut microbiome in irritable bowel syndrome have been reported, however, this association is poorly understood in fibromyalgia. Our aim was to summarise the research reporting on the gastrointestinal microbiome and its biomarkers in people with fibromyalgia. Methods: A systematic review of published original research reporting on the gastrointestinal microbiota and its biomarkers in adults with a diagnosis of fibromyalgia was undertaken. Results: From 4771 studies, 11 met our inclusion criteria and were separated into four main groups: papers reporting Helicobacter pylori; other gut bacterial markers; metabolomics and other biomarkers, which included intestinal permeability and small intestinal bacterial overgrowth. Conclusion: The results suggest there is a paucity of quality research in this area, with indications that the gut microbiota may play a role in fibromyalgia within the emerging field of the gut-musculoskeletal axis. Further investigations into the relationship between the gut microbiota, gut dysfunction and fibromyalgia are warranted.

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Section: Resultsmentioning

confidence: 99%

Determining the association between fibromyalgia, the gut microbiome and its biomarkers: A systematic review

Erdrich

Hawrelak

Myers

et al. 2020

BMC Musculoskelet Disord

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“…All subjects in Gezici's Turkish study had fibromyalgia and dyspepsia; 78% were positive for H. pylori (18), similar to the overall prevalence in that country (33). Cytotoxin-associated gene A (CagA)positive strains of H. pylori are associated with a higher risk of dyspepsia (34), but none of the studies included in this review evaluated virulence factors.…”

Section: Helicobacter Pylorimentioning

confidence: 94%

“…In summary, the studies provide weak evidence that H. pylori may play a role in the symptomology of fibromyalgia, and while the exact relationship is uncertain, the improvement seen in pain scores just 3 weeks after antibiotic treatment of H. pylori (18) warrants a systematic and rigourous investigation.…”

Section: Helicobacter Pylorimentioning

confidence: 95%

“…None of the included studies utilised stool antigen or 13C-urea breath tests, and two (18,20) performed culture following biopsy. Each of these are more reliable than serology for H. pylori diagnosis (27).…”

Section: Helicobacter Pylorimentioning

confidence: 99%

“…Akkaya's study found no differences in regards to any of the clinical features evaluated (19), whereas Olama et al, described significant associations between H. pylori immunoglobulin-G (IgG) -positive patients and disease markers, including: post-exertion pain, morning stiffness, confusion, mood, tension headache, sleep disturbance, dyscognition, changes in appetite and fatigue (all p < 0.05) (17). Gezici's group reported a significant reduction in pain, as evaluated by the number of tender points, following H.pylori eradication (p < 0.001)(18).A significant association between the differential abundance of several taxa and some indices of the 2016 ACR Fibromyalgia criteria (such as pain intensity, widespread pain index (WPI), dyscognition), and quality of life scores (including fatigue) was reported by Minerbi's group (all p < 0.05). Some operational taxonomic units were found to be inversely related to many of the same indicators in unrelated controls(23).…”

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confidence: 97%

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Determining the association between fibromyalgia, the gut microbiome and its biomarkers: A systematic review

Erdrich

Hawrelak

Myers

et al. 2020

Preprint

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Background The association between fibromyalgia and irritable bowel syndrome is well-established. Alterations in the composition and diversity of the gut microbiome in irritable bowel syndrome have been reported, however, this association is poorly understood in fibromyalgia. Our aim was to summarise the research reporting on the gastrointestinal microbiome and its biomarkers in people with fibromyalgia.Methods A systematic review of published original research reporting on the gastrointestinal microbiota and its biomarkers in adults with a diagnosis of fibromyalgia was undertaken.Results From 4771 studies, 11 met our inclusion criteria and were separated into four main groups: papers reporting Helicobacter pylori ; other gut bacterial markers; metabolomics and other biomarkers, which included intestinal permeability and small intestinal bacterial overgrowth.Conclusion The results suggest there is a paucity of quality research in this area, with indications that the gut microbiota may play a role in fibromyalgia within the emerging field of the gut-musculoskeletal axis. Further investigations into the relationship between the gut microbiota, gut dysfunction and fibromyalgia are warranted.

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The Relationship between Daily Physical Activity, Psychological Factors, and Vegetative Symptoms in Women with Fibromyalgia: A Cross-Sectional Observational Study

Navarro-Ledesma

Pruimboom

Lluch

et al. 2022

IJERPH

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Nowadays, there is evidence that relates the amount of physical activity, as well as the impact of psychological factors, to the intensity of symptoms present in patients with fibromyalgia (FM). However, there are no studies which correlate the level of association of physical activity, psychological factors and vegetative symptoms in the FM population. The study has a cross-sectional observational design with 41 participants being recruited from a private clinic and rehabilitation service. The Autonomic Symptom Profile (Compass-31) to assess vegetative symptoms, the GODIN questionnaire to evaluate the level of leisure activity, and the pain catastrophizing scale, Tampa Kinesiophobia Scale and Self-Efficacy Scale to assess psychological factors, were used. A low and significant level of association was found between pain catastrophizing (PCS) and Kinesiophobia (r = 0.398; p < 0.01), as well as with catastrophizing and vegetative symptoms (r = 0.428; p < 0.05). Furthermore, a low and significant level of association was also found between self-efficacy and vegetative symptoms (r = 0.397; p < 0.05). No association was found between the level of daily physical activity (measured by the Godin Leisure questionnaire) and vegetative symptoms, nor with any psychological factor studied. There is an association between vegetative symptoms and psychological factors. Nevertheless, more research which takes other factors into account, such as lifestyle and nutritional, is needed.

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The Effects of Helicobacter Pylori Eradication on the Number of Tender Points, Sleep Quality, Depression, and Anxiety in Patients With Fibromyalgia

Cited by 4 publications

References 12 publications

Determining the association between fibromyalgia, the gut microbiome and its biomarkers: A systematic review

Determining the association between fibromyalgia, the gut microbiome and its biomarkers: A systematic review

Determining the association between fibromyalgia, the gut microbiome and its biomarkers: A systematic review

The Relationship between Daily Physical Activity, Psychological Factors, and Vegetative Symptoms in Women with Fibromyalgia: A Cross-Sectional Observational Study

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