The effects of heat stress on cognition in persons with multiple sclerosis

Hämäläinen, Päivi; Ikonen, Anna; Romberg, Anders; Helenius, Hans; Ruutiainen, Juhani

doi:10.1177/1352458511422926

Cited by 23 publications

(25 citation statements)

References 29 publications

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“…The results on the effects of heat on cognition will be presented in a separate report [21]. Assessments were conducted at baseline and immediately, at 1 hour, as well as at 24 hours following the heat exposure.…”

Section: Introductionmentioning

confidence: 99%

The effects of heat stress on physical functioning in persons with multiple sclerosis

Romberg¹,

Ikonen²,

Ruutiainen³

et al. 2012

Journal of the Neurological Sciences

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Section: Introductionmentioning

confidence: 99%

The effects of heat stress on physical functioning in persons with multiple sclerosis

Romberg¹,

Ikonen²,

Ruutiainen³

et al. 2012

Journal of the Neurological Sciences

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“…In our previous publications we reported that the core body temperature of MS patients rises more during heat exposure than that of the HCs and that heat temporarily impairs the cognitive and physical performance of MS patients with heat sensitivity (1,2). In the present study, the data from our previous studies were further analyzed to determine whether the heat-induced decline is observed with the MSFC composite score.…”

Section: Discussionmentioning

confidence: 88%

“…The study was conducted in Masku neurological rehabilitation center (Finland), and the study group used in the current analysis was the same as our previous studies (1,2). In total, 22 individuals with MS and 19 healthy controls were included in the analysis.…”

Section: Subjectsmentioning

confidence: 99%

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Multiple Sclerosis Functional Composite as a Measure of the Effects of Heat in Multiple Sclerosis

Ryosa

Romberg

Ruutiainen³

et al. 2016

Middle East J Rehabil Health

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“…Nonetheless, cognitive fatigue is quite visible during cognitive tasks. 10 The necessity of early intervention is emphasized and can be achieved by an individually tailored program, through a multimodal neuropsychological approach if necessary because of widespread cognitive impairment. …”

mentioning

confidence: 99%

Cumulative evidence for MS as a neural network disconnection syndrome consistent with cognitive impairment mechanisms and the confounding role of fatigue and depression-outlook from the Fourth Nordic MS symposium

Ettinger-Veenstra

2016

Acta Neurol Scand

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The Fourth Nordic MS symposium served as a platform to present an overview over the rise and impact of cognitive impairment in people with MS, from early stages on, impairing their quality of life. After discussing MS and cognitive impairment symptoms, a review on the pathophysiology underlying cognitive impairment was given, followed by a talk on neuroimaging highlighting cortical reorganization in MS-affected brains.As a conclusion, therapy and treatment options were discussed. The symposium presented several cutting-edge research studies providing or testing working models that appear successful in predicting and explaining cognitive impairment in MS, such as the disconnection syndrome. R E V I E W A R T I C L ECumulative evidence for MS as a neural network disconnection syndrome consistent with cognitive impairment mechanisms and the confounding role of fatigue and depression-outlook from the Fourth Nordic MS symposium H. van Ettinger-Veenstra 1,2The prevalence of cognitive impairment in people with MS is well known, but several facets of its mechanisms are poorly understood.The disconnection syndrome description of MS characterized by network disruption is one of the most recurring models underlying cognitive impairment. It is thought to be caused by several neurodegenerative processes that start early on. Cognitive impairment is already reliably reported in early stages by around half of the MS population. Initially, it manifests itself by changes in mood, fatigue, working memory decline, and other cognitive deficits, 1,2 which can be temporary. An important current debate addresses whether neural changes related to cognitive functioning in MS are adaptive or maladaptive. Even though many neural changes are still referred to as conceivably compensatory, perhaps most neural changes should be assumed to be maladaptive as they are often paired with cognitive impairments. Damage of strategic gray matter areas such as the thalamus, which has many cortical and subcortical connections and shows atrophy already during the earliest disease stages, may play a distinctive role in cognitive dysfunction. However, they tend to underestimate their cognitive performance. 2,8The first session addressing cognitive symptoms in MS was opened by Päivi Hämäläinen who presented the effect of rehabilitation techniques on cognitive impairment. 9 Cognitive impairment cannot be explained by the symptom of fatigue, which about 80% of the MS patients experience. Nonetheless, cognitive fatigue is quite visible during cognitive tasks. 10 The necessity of early intervention is emphasized and can be achieved by an individually tailored program, through a multimodal neuropsychological approach if necessary because of widespread cognitive impairment.

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The effects of heat stress on cognition in persons with multiple sclerosis

Abstract: A significant increase in core body temperature during heat stress is associated with a mild and reversible worsening of the PASAT 3" performance, while visual vigilance performance seems to remain almost unaffected.

Cited by 23 publications

References 29 publications

The effects of heat stress on physical functioning in persons with multiple sclerosis

The effects of heat stress on physical functioning in persons with multiple sclerosis

Multiple Sclerosis Functional Composite as a Measure of the Effects of Heat in Multiple Sclerosis

Cumulative evidence for MS as a neural network disconnection syndrome consistent with cognitive impairment mechanisms and the confounding role of fatigue and depression-outlook from the Fourth Nordic MS symposium

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