The effects of Gua sha on symptoms and inflammatory biomarkers associated with chronic low back pain: A randomized active-controlled crossover pilot study in elderly

Yuen, Jean Tak Alice Loke; Tsang, Wai Nam; Tse, Sonny H M; Loo, Wings T.Y.; Chan, Suk-Tak; Wong, Diana L.Y.; Chung, Hilary H.Y.; Tam, Jacky K.K.; Choi, Kup‐Sze; Chiang, Chung Lim Vico

doi:10.1016/j.ctim.2017.03.010

Cited by 23 publications

(25 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CLBP was the most frequent CP condition studied (n ¼ 6 studies; Ardito et al, 2017;Braden et al, 2016;Cho et al, 2015;Lee et al, 2014;Schmidt et al, 2015;Yuen et al, 2017;Zgierska et al, 2016), followed by fibromyalgia syndrome (FMS; n ¼ 2; Coherence: Treatment group demonstrated increased postintervention cardiac coherence ratio, t(7) Gerdle et al, 2016;Grossman et al, 2017) . In two articles, researchers reported on individuals with CP and an additional primary diagnosis, specifically, posttraumatic stress disorder (Scioli-Salter et al, 2016) and Parkinson's disease (Törnhage et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

“…Researchers in three studies (discussed in four articles) assessed the effects of physical exercise interventions on CP and biological mechanisms (Cho et al, 2015;Gerdle et al, 2016;Lee et al, 2014;Scioli-Salter, 2016). In two studies, researchers evaluated nonpharmacologic stress reduction interventions that involved the manipulation of tissue and joints, specifically tactile massage (Törnhage et al, 2013) and Gua sha, a traditional integrative therapy that can be used to reduce muscle pain and involves the application of pressure in a stroking sequence until petechiae form (Yuen et al, 2017). Yuen et al (2017) compared the Gua sha treatment to a hydrocollator hot-pack treatment in a randomized AB/BA crossover study design sequence (i.e., subjects received treatment A then treatment B or vice versa) separated by a 28-day washout period between treatments.…”

Section: Resultsmentioning

confidence: 99%

“…In two studies, researchers evaluated nonpharmacologic stress reduction interventions that involved the manipulation of tissue and joints, specifically tactile massage (Törnhage et al, 2013) and Gua sha, a traditional integrative therapy that can be used to reduce muscle pain and involves the application of pressure in a stroking sequence until petechiae form (Yuen et al, 2017). Yuen et al (2017) compared the Gua sha treatment to a hydrocollator hot-pack treatment in a randomized AB/BA crossover study design sequence (i.e., subjects received treatment A then treatment B or vice versa) separated by a 28-day washout period between treatments. The hot-pack therapy included the application of a moist heating pack placed superficially on the low back in the same approximate location of the Gua sha treatment.…”

Section: Resultsmentioning

confidence: 99%

“…Across the 13 articles, researchers used ten different methods to evaluate pain. For measuring pain severity, they used the Numeric Rating Scale (Ardito et al, 2017;Zgierska et al, 2016), the Brief Pain Inventory (Berry et al, 2014;Crisp et al, 2016;Zgierska et al, 2016), the Oswestry Low Back Pain Scale (Braden et al, 2016), and a Visual Analog Scale (Gerdle et al, 2016;Lee et al, 2014;Schmidt et al, 2015;Yuen et al, 2017). In two of the MBSR studies, researchers examined pain perception using the Pain Perception Scale (Grossman et al, 2017;Schmidt et al, 2015).…”

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

A Systematic Review of Biological Mechanisms and Chronic Pain Outcomes During Stress Reduction Interventions

Carney

Young

Guite

et al. 2020

Biological Research For Nursing

View full text Add to dashboard Cite

Background: Nonpharmacologic stress reduction interventions provide an opportunity to modify chronic pain trajectories; however, the biological mechanisms underlying these interventions are poorly understood. Objectives: To examine clinical literature published in 2012–2018 with the goals of (1) identifying which biological mechanisms or biomarkers are currently being measured in nonpharmacologic stress reduction intervention studies for individuals with chronic pain and (2) evaluating the evidence to determine whether these stress reduction interventions lead to changes in (a) pain outcomes and/or (b) measured biomarkers. Data sources: Scientific articles in the electronic databases PubMed/Medline, Cumulative Index of Nursing and Allied Health Literature, PsychINFO, and SCOPUS following the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Study selection: Randomized controlled trials and quasi-experimental studies that recruited subjects with a chronic pain condition, examined a relationship between a nonpharmacologic stress reduction intervention and pain-related outcome(s), and included measurement of a biomarker. Results: The 13 articles that met inclusion criteria spanned four nonpharmacologic stress reduction categories: mindfulness-based stress reduction, physical exercise, manual therapies, and biofeedback. Methods for studying biomarkers included measuring biological samples, neurological function, and autonomic control. Although all studies investigated both biological measures and pain outcomes, only three demonstrated an association between the biomarker(s) and pain-related outcomes. Conclusions: The results of this review highlight the complex nature of stress–pain relationships and the lack of rigorous clinical research identifying specific stress-related biological factors that modulate pain outcomes. Stress reduction interventions remain a favorable method for symptom management in patients living with chronic pain, but consistency in study measures and design is needed for robust evaluation.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

A Systematic Review of Biological Mechanisms and Chronic Pain Outcomes During Stress Reduction Interventions

Carney

Young

Guite

et al. 2020

Biological Research For Nursing

View full text Add to dashboard Cite

show abstract

“…Different styles of MMT exist for the management of musculoskeletal system diseases,[ 17 18 19 ] of which gua sha is one of the most common. [20] Gua sha therapy is also known as cao gio, khoud lam, and ga sal in different Asian countries. [21] In ancient Chinese textbooks, “sha” refers to the red, millet-sized rash associated with blood stasis, while “gua” means instrument-assisted scraping at specific acupuncture points and meridians.…”

Section: Introductionmentioning

confidence: 99%

Gua sha therapy for chronic low back pain

Wang

et al. 2020

Medicine

View full text Add to dashboard Cite

Background: Non-specific chronic low back pain (LBP) is a debilitating disease that profoundly impacts patients’ daily physical function and quality of life. Gua sha therapy, as an easy-to-use and noninvasive complementary modality, has been widely used clinically in patients with non-specific chronic LBP. The aim of this study is to test the potential benefits and harms of gua sha therapy on patients with non-specific chronic LBP. Methods: Ten English databases, 3 Korean databases, 6 Chinese databases, 1 Japanese database, and 2 Brazilian databases will be searched from their inception to September 2019. Randomized controlled trials will be included if gua sha therapy was used as the sole treatment or as a part of combination therapy with other treatments in patients with non-specific chronic LBP. Two reviewers will independently extract the data and assess the methodological quality using the Cochrane criteria for risk of bias. The meta-analysis will be performed using Review Manager 5.3 software. Results: The findings of this systematic review will be published in a peer-reviewed journal. Conclusion: This systematic review will provide more evidence regarding the clinical usage of gua sha therapy for non-specific chronic LBP. Trial registration number: CRD42019134567

show abstract

Preparation of Hard Tissues Like Bone or Cartilage for Shotgun Mass Spectrometry Analysis of the Proteome

Yuen

Lam

2021

Current Protocols

View full text Add to dashboard Cite

Proteomic analyses of intervertebral discs (IVDs) reveal information for understanding the fundamentals of biological processes and pathogenesis but also provide insights for novel pharmaceutical development. Sensitive mass spectrometry techniques and bioinformatics have advanced the detection and identification of proteins from any sample. Due to the challenges of catastrophic sample-loss artifacts during hard-tissue extraction, however, many researchers have omitted the cartilage endplates of IVDs for protein extraction, analyzing only the cellular components of the annulus fibrosus and/or nucleus pulposus. The full proteomic picture of IVDs is compromised without extracting proteins from intact IVDs. Here, we describe a novel preparation method using snap-freeze grinding, which allows for mechanical disruption and customized chemical lysis of hard tissues such as bone or cartilage. This method replaces the time-consuming and insufficient conventional tissue homogenization methods. Sample loss and contamination could be minimized during proteolysis by using an in-solution protein digestion and desalting procedure. We demonstrate excellent proteome coverage with intact mouse IVDs by analyzing samples in a hybrid quadrupole time-of-flight tandem mass spectrometer.

show abstract

The effects of Gua sha on symptoms and inflammatory biomarkers associated with chronic low back pain: A randomized active-controlled crossover pilot study in elderly

Cited by 23 publications

References 34 publications

A Systematic Review of Biological Mechanisms and Chronic Pain Outcomes During Stress Reduction Interventions

A Systematic Review of Biological Mechanisms and Chronic Pain Outcomes During Stress Reduction Interventions

Gua sha therapy for chronic low back pain

Preparation of Hard Tissues Like Bone or Cartilage for Shotgun Mass Spectrometry Analysis of the Proteome

Contact Info

Product

Resources

About