volume 8, issue 4, P642-661 2016
DOI: 10.18632/aging.100895
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Davina Derous, Sharon E. Mitchell, Cara L. Green, Luonan Chen, Jing‐Dong J. Han, Yingchun Wang, Daniel E.L. Promislow, David Lusseau, John R. Speakman, Alex Douglas

Abstract: Food intake and circadian rhythms are regulated by hypothalamic neuropeptides and circulating hormones, which could mediate the anti‐ageing effect of calorie restriction (CR). We tested whether these two signaling pathways mediate CR by quantifying hypothalamic transcripts of male C57BL/6 mice exposed to graded levels of CR (10 % to 40 %) for 3 months. We found that the graded CR manipulation resulted in upregulation of core circadian rhythm genes, which correlated negatively with circulating levels of leptin,…

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