The Effects of Glutamine Supplementation on Reducing Mortality and Morbidity among Burn Patients: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Mortada, Hatan; Alhindi, Nawaf; Abukhudair, Abdulrahman; Alanazi, Shahad; AlSahli, Alaa; Arab, Khalid

doi:10.1016/j.jpra.2022.09.003

Cited by 3 publications

(2 citation statements)

References 40 publications

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“…Additionally, there is a lack of investigations into the tolerability of this amino acid among the older adult population. Our hypothesis was that glutamine is safe for older adults, as previously established for younger patients ( 15 , 23 - 26 ). To test this hypothesis, we conducted a double-blind placebo-controlled randomized study comparing older adults receiving oral effervescent glutamine (EGln) or maltodextrin (placebo) for 60 days.…”

Section: Introductionmentioning

confidence: 89%

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Tolerability of glutamine supplementation in older adults: a double-blind placebo-controlled randomized clinical trial

Nóbrega,

Silva,

Rampani

et al. 2024

Braz J Med Biol Res

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In this double-blind placebo-controlled randomized investigation, we assessed the tolerability of glutamine in older adults recruited from three daycare centers. The relevance of studying glutamine supplementation in elderly patients lies in its potential to provide a well-tolerated intervention. Glutamine, a crucial amino acid, plays a vital role in various physiological processes, including immune function and protein synthesis. Understanding its impact on older adults is essential, given the potential implications for their health and well-being. Participants received a daily dose of 12.4 g of oral effervescent glutamine (EGln group) or maltodextrin (placebo group) for 60 days. Fifteen patients from each group completed the study. The mean ages were 77.0±9.1 and 79.0±6.9 years for the EGln and placebo groups, respectively. We evaluated body mass index, aminogram, hemogram, plasma levels of glucose, prealbumin, albumin, urea, creatinine, uric acid, C-reactive protein, vitamin D, calcium, sodium, potassium, and the plasma activities of aspartate aminotransferase and alanine aminotransferase. Notably, we quantified a broad array of inflammatory markers and growth factors providing a holistic understanding of the potential effects of glutamine supplementation. The results demonstrated that oral glutamine did not induce significant changes in any evaluated parameters, and no adverse effects were reported. This finding suggested that the dosage of glutamine used in this study was well-tolerated and safe. This information contributes to the broader understanding of glutamine supplementation, emphasizing its safety and supporting its potential as a viable intervention for maintaining health in aging individuals.

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Section: Introductionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 92%

Tolerability of glutamine supplementation in older adults: a double-blind placebo-controlled randomized clinical trial

Nóbrega,

Silva,

Rampani

et al. 2024

Braz J Med Biol Res

View full text Add to dashboard Cite

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Vitamin D administration increases serum alanine concentrations in thermally injured mice

Sato,

Hishiki,

Masugi

et al. 2024

Biochemical and Biophysical Research Communications

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Glutamine Supplementation on Burn Patients: A Systematic Review and Meta-analysis

Tao,

Xu,

Zhou

et al. 2024

Journal of Burn Care &Amp; Research

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To evaluate the effect of glutamine supplement on patients with burns, we conducted a systematic review and meta-analysis via synthesizing up-to-date studies. Databases including PubMed, Cochrane Central Register, EMBASE, and Google scholar, Wanfang data, and ClinicalTrials.gov were searched up to Oct, 2023 to find randomized trials evaluating glutamine supplement on patients with burns. Main outcomes included hospital stay, in hospital mortality, infection, and wound healing. Twenty-two trials which randomized a total of 2,170 patients were included in this meta-analysis. Pooled the length of hospital stay was shortened by glutamine supplement (WMD = -7.95, 95%CI -10.53 to -5.36, I2 = 67.9%, 16 trials)). Both pooled wound healing rates (WMD = 9.15, 95%CI 6.30 to 12.01, I2 = 82.7%, six studies) and wound healing times (WMD = -5.84, 95%CI -7.42 to -4.27, I2 = 45.7%, seven studies) were improved by glutamine supplement. Moreover, glutamine supplement reduced wound infection (RR = 0.38, 95%CI 0.21 to 0.69, I2 = 0%, three trials), but not non-wound infection (RR = 0.88, 95%CI 0.73 to 1.05, I2 = 39.6%, 9 trials). Neither in hospital mortality (RR = 0.95, 95%CI 0.74 to 1.22, I2 = 36.0%, eight trials) nor the length of ICU stay (WMD = 1.85, 95%CI -7.24 to 10.93, I2 = 78.2%, five studies) was improved by glutamine supplement. Subgroup analysis showed positive effects were either influenced by or based on small-scale, single center studies. Based on the current available data, we do not recommend routine use of glutamine supplement for burn patients in hospital. Future large-scale randomized trials are still needed to give a conclusion about the effect of glutamine supplement on burn patients.

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The Effects of Glutamine Supplementation on Reducing Mortality and Morbidity among Burn Patients: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Cited by 3 publications

References 40 publications

Tolerability of glutamine supplementation in older adults: a double-blind placebo-controlled randomized clinical trial

Tolerability of glutamine supplementation in older adults: a double-blind placebo-controlled randomized clinical trial

Vitamin D administration increases serum alanine concentrations in thermally injured mice

Glutamine Supplementation on Burn Patients: A Systematic Review and Meta-analysis

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