The effects of glucocorticoids on the inhibition of emotional information: A dose–response study

Taylor, Véronique A.; Ellenbogen, Mark A.; Washburn, Dustin; Joober, Ridha

doi:10.1016/j.biopsycho.2010.10.001

Cited by 34 publications

(24 citation statements)

References 70 publications

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“…People with Cushing's syndrome have poorer memory (8), and a recent study has shown a dose-dependent inhibitory effect of glucocorticoids on emotional information processing in healthy volunteers (25). Here, we have found some evidence that glucocorticoid treatment was associated with poorer cognitive performance, mainly in processing speed.…”

Section: Discussionsupporting

confidence: 50%

Glucocorticoid treatment and impaired mood, memory and metabolism in people with diabetes: the Edinburgh Type 2 Diabetes Study

Reynolds

Labad

Sears

et al. 2012

European Journal of Endocrinology

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ObjectiveBoth type 2 diabetes and glucocorticoid therapy are highly prevalent. Although people with type 2 diabetes may be more susceptible to adverse effects of glucocorticoids, and it is recommended that glucocorticoid therapy is avoided for fear of worsening glycaemic control, the extent to which this advice is followed and the consequences when glucocorticoids are prescribed are poorly documented. The aim was to assess the characteristics of people with type 2 diabetes prescribed glucocorticoids in a real-world setting and to quantify resulting adverse effects.DesignCross-sectional cohort study.MethodsCardiometabolic variables, body fat distribution, cognitive function and mood were studied in the 1066 participants of the Edinburgh Type 2 Diabetes Study, of whom 162 (15%) were taking systemic, topical or inhaled glucocorticoids.ResultsGlucocorticoid therapy was more common in women and in smokers but was not avoided in patients with diabetic complications or cardiovascular risk factors. People taking glucocorticoids were more centrally obese with slightly higher HbA1c and total serum cholesterol but were no more likely to have hepatic steatosis or hypertension. Glucocorticoid treatment was associated with substantially lower mood and greater anxiety. Women taking glucocorticoid therapy were twice as likely to report depressive symptoms compared with those not taking treatment. Glucocorticoid therapy was also associated with poorer cognitive function among those with subclinical atherosclerosis, as indicated by low ankle–brachial pressure index.ConclusionsGlucocorticoids are prescribed commonly for people with type 2 diabetes despite being associated with adverse indices of glycaemic control, cardiovascular risk factors, mood and cognitive function.

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Section: Discussionsupporting

confidence: 50%

Glucocorticoid treatment and impaired mood, memory and metabolism in people with diabetes: the Edinburgh Type 2 Diabetes Study

Reynolds

Labad

Sears

et al. 2012

European Journal of Endocrinology

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“…Another line of evidence suggests that cortisol levels affect processing, such that inhibition of emotional information (e.g., angry faces) occurs at lower doses of hydrocortisone (10 mg), but not for higher hydrocortisone doses compared to placebo. Of particular note, this effect differed for anxious participants, as they exhibited inhibition of angry faces at higher, but not lower doses (Taylor, Ellenbogen, Washburn, & Joober, 2011). Although these studies differed in their dose dependent findings, overall the research indicates increased levels of cortisol effect executive cognitive functioning.…”

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confidence: 99%

“…Specifically, we suggest a mediation model, where anxiety explains the underlying relationship between exposure to acute stress and working memory. Further, acute stress results in higher cortisol levels (Duncko et al, 2009; Schoofs et al, 2009) and the effect of cortisol on working memory may be dependent on whether increases in cortisol are low or high when exposed to stress (Lupien et al, 1999; Taylor et al, 2011). As such, we test a model in which cortisol is a moderator of the mediated relationship (i.e., anxiety mediating the relationship between exposure to stress and working memory).…”

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confidence: 99%

Anxiety mediates the effect of acute stress on working memory performance when cortisol levels are high: a moderated mediation analysis

Hood

Pulvers

Spady

et al. 2015

Anxiety, Stress, & Coping

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“…La acción de estas hormonas es una de las claves para llegar a la comprensión de las relaciones entre la memoria y las emociones (McGaugh & Roozendaal, 2002;Roozendaal, 2000;Taylor, Ellenbogen, Washburn & Joober, 2011), ya que las mismas modulan selectivamente la memoria de eventos que son emocionalmente significativos.…”

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Modulación de la memoria emocional: una revisión de los principales factores que afectan los recuerdos

Justel¹,

Psyrdellis

Ruetti

2014

SumaPsi

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The effects of glucocorticoids on the inhibition of emotional information: A dose–response study

Cited by 34 publications

References 70 publications

Glucocorticoid treatment and impaired mood, memory and metabolism in people with diabetes: the Edinburgh Type 2 Diabetes Study

Glucocorticoid treatment and impaired mood, memory and metabolism in people with diabetes: the Edinburgh Type 2 Diabetes Study

Anxiety mediates the effect of acute stress on working memory performance when cortisol levels are high: a moderated mediation analysis

Modulación de la memoria emocional: una revisión de los principales factores que afectan los recuerdos

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