The effects of frailty and cognitive impairment on 3-year mortality in older adults

Lee, Yunhwan; Kim, Jinhee; Chon, Doukyoung; Lee, Kyung-Eun; Kim, Jae Hyun; Myeong, Suk; Kim, Seihee

doi:10.1016/j.maturitas.2017.10.006

Cited by 75 publications

(66 citation statements)

References 29 publications

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“…Frailty is a common geriatric syndrome that is partially reversible and characterized by age-related decline in physiologic reserves and function of multiple systems, resulting in increasing vulnerability triggered by minor stressor events and further leading to negative health outcomes, including falls, disability, hospitalization and mortality [13][14][15]. A growing body of evidence has shown that cognitive impairment and frailty are closely related in populations with advanced age in that they may share similar etiologies.…”

Section: Introductionmentioning

confidence: 99%

Association between motoric cognitive risk syndrome and frailty among older Chinese adults

Shen

Zeng

et al. 2020

BMC Geriatr

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Background: Motoric cognitive risk syndrome (MCR) is a newly proposed predementia syndrome incorporating subjective cognitive complaints and slow gait. Previous studies have reported that subjective cognitive complaints and slow gait are associated with frailty in cognitively unimpaired older adults, but little is known about the link between MCR and frailty in older adults. Therefore, the aim of the study was to explore the associations of MCR and its components with frailty in older Chinese adults. Methods: In an observational cross-sectional study, a total of 429 older adults aged 60 years and older were admitted to the geriatric department. According to MCR criteria, all participants were classified into 4 groups: 1) the MCR group; 2) the subjective cognitive complaints only group; 3) the slow gait only group; and 4) the healthy control group. Physical frailty was assessed by the Clinical Frailty Scale (CFS). Multivariate logistic regression analysis was used to examine the association between MCR and frailty in older adults.Results: The prevalence rates of subjective cognitive complaints, slow gait and MCR were 15.9, 10.0 and 4.0%, respectively. After adjusting for confounding variables, the logistic regression analysis showed that slow gait (odds ratio [OR]: 3.40, 95% confidence interval [CI]: 1.40-8.23, P = 0.007) and MCR (OR: 5.53, 95% CI: 1.46-20.89, P = 0.012) were independently associated with frailty, but subjective cognitive complaints were not. Conclusions: MCR and slow gait were significantly associated with frailty in older Chinese adults. Further studies should prospectively determine the causal relationship between MCR and frailty.

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Section: Introductionmentioning

confidence: 99%

Association between motoric cognitive risk syndrome and frailty among older Chinese adults

Shen

Zeng

et al. 2020

BMC Geriatr

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“…We cannot measure long-term progression about cognitive function on mortality. Previous studies demonstrated that both cognitive impairment and disability were independent of adverse impact on mortality [26,27]. Therefore, the interaction synergistic effects between ADLs and cognitive impairment were tested in the models.…”

Section: Discussionmentioning

confidence: 99%

Association of cognitive impairment and elderly mortality: differences between two cohorts ascertained 6-years apart in China

Duan

Gao

et al. 2020

BMC Geriatr

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Background: Cognitive impairment is a major contributor to mortality among the elderly. However, the relationship between cognitive impairment evaluated by educational levels and mortality and the trend between cognitive impairment and mortality with time are unclear. We aim to evaluate the differences in associations of cognitive impairment, taking the stratification by educational levels into account, with all-cause mortality and further explore the relationship of cognitive impairment with mortality in different age and sex groups in two cohorts ascertained 6 years apart in China. Methods: A total of 13,906 and 13,873 Chinese elderly aged 65 years and older were included in the 2002-2008 and 2008-2014 cohorts from the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Mortality data was ascertained from interviews with family members or relatives of participants. Cognitive function, evaluated by the Mini-Mental State Examination (MMSE), were defined by different cutoffs taking educational background into account. Cox models were used to explore the relationship of cognitive impairment with mortality.

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“…En otro estudio longitudinal, Solfrizzi et al (11) demostraron que la fragilidad cognitiva es un predictor a corto plazo (3,5 años) y largo plazo (7,0 años) de mortalidad. Del mismo modo, Yunhwan Lee y colaboradores compararon personas sin fragilidad ni deterioro cognitivo con aquellos que sí lo presentaban y encontraron una tasa de supervivencia a 3 años menor en el último grupo (HR: 1,92; IC95%: 1,26-2,93; p = 0,003), por lo que se consideró que fragilidad física y deterioro cognitivo son predictores significativos de mortalidad a 3 años en adultos mayores no institucionalizados (19).…”

Section: Impactounclassified

Fragilidad cognitiva, un desafío en evolución

et al. 2019

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Dentro de los principales desafíos relacionados con el envejecimiento se encuentran la fragilidad y el deterioro cognitivo, condiciones que se han relacionado con aumento en la declinación funcional, la discapacidad y el deterioro en la calidad de vida. Durante los últimos años se ha demostrado la relación bidireccional entre estas dos condiciones clínicas y dentro del Grupo de Consenso Internacional en Toulouse, Francia, surgió el término fragilidad cognitiva, en el 2013. Ese estado reversible se ha considerado un nuevo síndrome geriátrico, caracterizado por la coexistencia entre fragilidad física y deterioro cognitivo; sin embargo, aún sin criterios diagnósticos definidos. El objetivo es realizar una aproximación de la definición, fisiopatología, herramientas diagnósticas y su respectiva asociación con desenlaces adversos, para realizar un diagnóstico oportuno y aplicar intervenciones multidominio centradas en la actividad física, el enfoque nutricional y el entrenamiento cognitivo, que puedan modificar el curso de este estado dinámico y reversible, previniendo el deterioro funcional y mejorando la calidad de vida de las personas mayores.

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The effects of frailty and cognitive impairment on 3-year mortality in older adults

Cited by 75 publications

References 29 publications

Association between motoric cognitive risk syndrome and frailty among older Chinese adults

Association between motoric cognitive risk syndrome and frailty among older Chinese adults

Association of cognitive impairment and elderly mortality: differences between two cohorts ascertained 6-years apart in China

Fragilidad cognitiva, un desafío en evolución

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