The Effects of Female Sex Hormones on Ventricular Premature Beats and Repolarization Parameters in Physiological Menstrual Cycle

Doğan, Mehmet; Yi̇ği̇ner, Ömer; Uz, Ömer; Küçük, Uğur; Degirmencioglu, Gokhan; Işılak, Zafer; Uzun, Mehmet; Davulcu, R N Ezgi

doi:10.1111/pace.12821

Cited by 28 publications

(13 citation statements)

References 43 publications

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“…1,6 During the follicular phase, associated with a higher ratio of estrogen to progesterone concentration, the ventricular action potential and QT interval are prolonged in comparison with the luteal phase. These differences may explain some of the changes in arrhythmia frequency that have been reported during the menstrual cycle, including an increased risk for torsade de pointes VT during the follicular phase of the ovarian cycle.…”

Section: Sex Differences In Cardiac Electrophysiologymentioning

confidence: 99%

Atrial Fibrillation and Ventricular Arrhythmias

Gillis

2017

Circulation

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ABSRACT: Sex-specific differences in the epidemiology, pathophysiology, clinical presentation, clinical treatment, and clinical outcomes of atrial fibrillation (AF), sustained ventricular arrhythmias, and sudden cardiac death are recognized. Sex hormones cause differences in cardiac electrophysiological parameters between men and women that may affect the risk for arrhythmias. The incidence and prevalence of AF is lower in women than in men. However, because women live longer and AF prevalence increases with age, the absolute number of women with AF exceeds that of men. Women with AF are more symptomatic, present with more atypical symptoms, and report worse quality of life in comparison with men. Female sex is an independent risk factor for death or stroke attributable to AF. Oral anticoagulation therapy for stroke prevention has similar efficacy for men and women, but older women treated with warfarin have a higher residual risk of stroke in comparison with men. Women with AF are less likely to receive rhythm control antiarrhythmic drug therapy, electric cardioversion, or catheter ablation in comparison with men. The incidence and prevalence of sustained ventricular arrhythmias and sudden cardiac death are lower in women than in men. Women receiving implantable cardioverter defibrillators for primary prevention of sudden cardiac death are less likely to experience sustained ventricular arrhythmias in comparison with men. In contrast, women receiving a cardiac resynchronization therapy implantable cardioverter defibrillator for the treatment of heart failure are more likely to benefit than men. Women are less likely to be referred for implantable cardioverter defibrillator therapy despite current guideline recommendations. Women are more likely to experience a significant complication related to implantable cardioverter defibrillator implantation in comparison with men. Whether sex differences in treatment decisions reflect patient preferences or treatment biases requires further study.

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Section: Sex Differences In Cardiac Electrophysiologymentioning

confidence: 99%

Atrial Fibrillation and Ventricular Arrhythmias

Gillis

2017

Circulation

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“…In our study there was no significant change regarding supraphysiological oestradiol levels in terms of QT dispersion and corrected QT dispersion. Also, in the study in which we compared hormonal changes during physiological menstrual cycle and ECG and 24-h Holter ECG findings, there was no correlation between ovulation and QT dispersion [19]. There are also other studies showing that there is no significant relation between menstrual cycle and QT dispersion [4].…”

Section: Discussionmentioning

confidence: 81%

The effects of supraphysiological oestrogen levels on ventricular repolarisation parameters

et al. 2018

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“…It was reported that there were lower levels of estradiol in cases with idiopathic ventricular outflow tract arrhythmia compared to controls, 9 and that there were fewer counts of PVCs in the ovulation period than in the menstruation period. 10 Female sex hormones, especially estrogen, were suggested to play an important role in these clinical results. For premenopausal women, estrogen levels remain high during the ovulation phase and abruptly decrease at the end of the ovulation phase and become low at the beginning of the menstruation phase.…”

Section: Discussionmentioning

confidence: 99%

The efficacy of radiofrequency catheter ablation for menstruation-dependent incessant ventricular tachycardia: A case report

Okajima

Imai

Murase

et al. 2020

HeartRhythm Case Reports

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The Effects of Female Sex Hormones on Ventricular Premature Beats and Repolarization Parameters in Physiological Menstrual Cycle

Abstract: VPB frequency decreases with estradiol peak in the ovulation period. This suggests that estrogen may have protective effects against ventricular arrhythmias.

Cited by 28 publications

References 43 publications

Atrial Fibrillation and Ventricular Arrhythmias

Atrial Fibrillation and Ventricular Arrhythmias

The effects of supraphysiological oestrogen levels on ventricular repolarisation parameters

The efficacy of radiofrequency catheter ablation for menstruation-dependent incessant ventricular tachycardia: A case report

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