The Effects of Female Genital Mutilation on the Female Sexual Function: A Cross-Sectional Study

Abbas, Ahmed M.; Samir, M.; Abdel-Gaber, Reham Maher; Ali, Emad Eldien Kamal

doi:10.1016/j.fertnstert.2020.08.1341

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“…Researchers have shown the effects of chlorpromazine drug on fertility, sexual efficiency and bone mineral density (Bostwick etal ;2009). In another study treated female rats with three doses(3, 10 ,30mg\kg per day for 28 days which lead to significantly differences between the treated animals and the control group on the size of the normal corpora lutea and increased dysfunction of the ovaries dependent on the concentration of drug, the serum level of prolactin and progesterone hormones increase, while the levels of ( estradiol , LH and FSH) decline depending on the dose of drug, chlorpromazine induced unsuccessful matting of animals with decreased pregnancy rate (Zahra etal;2015).The results of this study have demonstrated decreased potential fertility at large doses of chlorpromazine drug.…”

Section: Discussion:-mentioning

confidence: 99%

Study of Reproductive efficiency and Histological Changes in Liver and Kidney Associated With Sub acute and Acute Dose of Chlorpromazine (Largctil) in Mice Mus Musculus

Zaynab A. Shabab

2020

UTJagr

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The study was conducted on laboratory mice with body weight of 20-25 g . The male mice was divided into three groups (A, B and C) each group contain three replicate and each replicate contain 5 animals. A and B group were treated orally with (1.8 and 3.6mg /kg/day) respectively, while C group used as control and orally given 0.9 % normal saline and determined the histological parameters during ( 21 days) and the second part of experiment was divided into 3 group from female mice each group consist of (6) female first the control treated with (0.9%Nacl) while the (second , third group) treated with chlorpromazine (1.8 and 3.6 mg /kg/day for 14 days before matting and then all females they were gathered to mate with normal male for sixteen days. The histological study showed In both doses of Chlorpromazine of liver and kidney was represent by necrosis, vacuolization, hemorrhage, and complete cell membrane degeneration in hepatocytes and kidney cells, as well as recorded the lymphocytes infiltration in treated group, While the control not showed any histopathological changes during the study. The results of second experiment show all females of experiment except the third group which treated with (3.6 )mg from chlorpromazine not conceive and delivered but the control group and second group was conceive.

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Section: Discussion:-mentioning

confidence: 99%

Study of Reproductive efficiency and Histological Changes in Liver and Kidney Associated With Sub acute and Acute Dose of Chlorpromazine (Largctil) in Mice Mus Musculus

Zaynab A. Shabab

2020

UTJagr

View full text Add to dashboard Cite

show abstract

The Effects of Female Genital Mutilation on the Female Sexual Function: A Cross-Sectional Study

Cited by 1 publication

References 0 publications

Study of Reproductive efficiency and Histological Changes in Liver and Kidney Associated With Sub acute and Acute Dose of Chlorpromazine (Largctil) in Mice Mus Musculus

Study of Reproductive efficiency and Histological Changes in Liver and Kidney Associated With Sub acute and Acute Dose of Chlorpromazine (Largctil) in Mice Mus Musculus

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