The effects of facemasks on airway inflammation and endothelial dysfunction in healthy young adults: a double-blind, randomized, controlled crossover study

Guan, Tianjia; Hu, Songhe; Han, Yiqun; Wang, Ruoyu; Zhu, Qindan; Hu, Yaoqian; Fan, Hongzhen; Zhu, Tong

doi:10.1186/s12989-018-0266-0

Cited by 53 publications

(22 citation statements)

References 80 publications

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“… 33 In terms of other individually modifiable risk factors, the relationship between blood pressure changes and primary headache should be highlighted, as they share mechanisms of action such as vascular endothelial dysfunction or poor cardiovascular autonomic regulation. 34 However, in our study we did not find a clear association between different comorbidities of the individual and the appearance of headache, except for tobacco consumption in the univariate analysis.…”

Section: Discussioncontrasting

confidence: 83%

Mask-associated ‘de novo’ headache in healthcare workers during the COVID-19 pandemic

et al. 2020

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ObjectivesThe pandemic caused by the new coronavirus (COVID-19) has changed care activities of health professionals. We analysed the possible association between the appearance of ‘de novo’ headache according to the type of mask used, the related factors and the impact of the cephalalgia on health professionals.MethodsCross-sectional study in a tertiary hospital in Extremadura, Spain. We provided an online questionnaire to healthcare workers during the period of maximum incidence of COVID-19 in our setting.ResultsThe subjects are n=306, 244 women (79.7%), with an average age of 43 years (range 23–65). Of the total, 129 (42.2%) were physicians, 112 (36.6%) nurses and 65 (21.2%) other health workers. 208 (79.7%) used surgical masks and 53 (20.3%) used filter masks. Of all those surveyed, 158 (51.6%) presented ‘de novo’ headache. The occurrence of a headache was independently associated with the use of a filter mask, OR 2.14 (95% CI 1.07 to 4.32); being a nurse, OR 2.09 (95% CI 1.18 to 3.72) or another health worker, OR 6.94 (95% CI 3.01 to 16.04); or having a history of asthma, OR 0.29 (95% CI 0.09 to 0.89). According to the type of mask used, there were differences in headache intensity, and the impact of a headache in the subjects who used a filter mask was worse in all the aspects evaluated.ConclusionThe appearance of ‘de novo’ headache is associated with the use of filter masks and is more frequent in certain healthcare workers, causing a greater occupational, family, personal and social impact.

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Section: Discussioncontrasting

confidence: 83%

Mask-associated ‘de novo’ headache in healthcare workers during the COVID-19 pandemic

et al. 2020

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“…Several studies have shown that pain intensity [30], the degree of headache disability, and the possibility of secondary headache occurrence are age-related factors [31]. In terms of other individually modifiable risk factors, the relationship between blood pressure changes and primary headache should be highlighted, as they share mechanisms of action such as vascular endothelial dysfunction or poor cardiovascular autonomic regulation [32]. However, in our study we did not find a clear association between different comorbidities of the individual and the appearance of headache, except for tobacco consumption in the univariant analysis.…”

Section: Discussionmentioning

confidence: 99%

Mask-associated de novo headache in healthcare workers during the Covid-19 pandemic

Ramírez-Moreno

Ceberino

González-Plata³

et al. 2020

Preprint

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Introduction: The pandemic caused by the new coronavirus (COVID-19) has led to changes in the development of health care activities by health professionals. We analysed whether there is an association between the appearance of de novo headache according to the type of mask used, the related factors, as well as the impact of the headache on health professionals. Method: cross-sectional study in a tertiary hospital in Extremadura, Spain. We administered an online questionnaire to healthcare workers during the period of maximum incidence of COVID-19 in our setting. Results: n=306, 244 women (79.7%), with an average age of 43 years (range 23-65). Of the total, 129 (42.2%) were physicians, 112 (36.6%) nurses and 65 (21.2%) other health workers. 208 (79.7%) used surgical masks and 53 (20.3%) used filtering masks. Of all those surveyed, 158 (51.6%) presented de novo headache. The occurrence of headache was independently associated with the use of a filtering mask, OR 2.14 (IC95% 1.07-4.32), being a nurse OR 2.09 (IC95% 1.18-3.72) or another health worker OR 6.94 (IC95% 3.01-16.04) or having a history of asthma OR 0.29 (IC95% 0.09-0.89). Depending on the type of mask used there were differences in headache intensity. And the impact of headache in the subjects who used a filtering mask was worse in the all aspects evaluated. Conclusions: The appearance of de novo headache is associated with the use of filtering masks and is more frequent in certain health care workers, causing a greater occupational, family, personal and social impact.

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“…While this amount of protection is likely inadequate for a worker who anticipates high lifetime exposure, in a situation where the general public is trying to temporarily reduce ambient exposure, such as with wildfire smoke, a 66-70% reduction in exposure for nearly everyone may be meaningful. In fact, in a general population cohort of non-fit-tested healthy adults, a crossover study in China found that there was less increase in airway inflammation (measured with exhaled nitric oxide) associated with air pollutant exposure when a study participant wore an N95, compared to wearing a sham N95 mask [103].…”

Section: Use Of Respirators By the General Publicmentioning

confidence: 99%

Health effects of wildfire smoke in children and public health tools: a narrative review

Holm

Miller

Balmes

2020

J Expo Sci Environ Epidemiol

108

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Wildfire smoke is an increasing environmental health threat to which children are particularly vulnerable, for both physiologic and behavioral reasons. To address the need for improved public health messaging this review summarizes current knowledge and knowledge gaps in the health effects of wildfire smoke in children, as well as tools for public health response aimed at children, including consideration of low-cost sensor data, respirators, and exposures in school environments. There is an established literature of health effects in children from components of ambient air pollution, which are also present in wildfire smoke, and an emerging literature on the effects of wildfire smoke, particularly for respiratory outcomes. Low-cost particulate sensors demonstrate the spatial variability of pollution, including wildfire smoke, where children live and play. Surgical masks and respirators can provide limited protection for children during wildfire events, with expected decreases of roughly 20% and 80% for surgical masks and N95 respirators, respectively. Schools should improve filtration to reduce exposure of our nation's children to smoke during wildfire events. The evidence base described may help clinical and public health authorities provide accurate information to families to improve their decision making.

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The effects of facemasks on airway inflammation and endothelial dysfunction in healthy young adults: a double-blind, randomized, controlled crossover study

Cited by 53 publications

References 80 publications

Mask-associated ‘de novo’ headache in healthcare workers during the COVID-19 pandemic

Mask-associated ‘de novo’ headache in healthcare workers during the COVID-19 pandemic

Mask-associated de novo headache in healthcare workers during the Covid-19 pandemic

Health effects of wildfire smoke in children and public health tools: a narrative review

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