The effects of extra virgin olive oil and canola oil on inflammatory markers and gastrointestinal symptoms in patients with ulcerative colitis

The High-Fat Diet Based on Extra-Virgin Olive Oil Causes Dysbiosis Linked to Colorectal Cancer Prevention

“…On the contrary, coconut-HFD reduced Neisseria abundance, and EVOO-HFD reduced not only Neisseria and Pseudomonas , but also Proteobacteria abundance ( Table 3 , Figure 7 C,D). To our knowledge, there are no studies that have described the beneficial or harmful effects related to Proteobacteria induced by EVOO, coconut or sunflower-HFD, however, some authors have described the protective effects of EVOO on immunomodulation in murine experimental ulcerative colitis and patients with ulcerative colitis [ 41 , 42 ], that could be associated not only with inflammatory processes involved on the MAPK and NFκB signalling pathways but also with microbiota modulation, as our results showed [ 43 ].…”

(Poly)phenols in Inflammatory Bowel Disease and Irritable Bowel Syndrome: A Review

“…The impact of PPs on individual gastrointestinal symptoms in UC is also explored in the literature, although data is scarce and studies are very heterogeneous in type of PPs, intervention, dose, and duration of study. Improvement in faecal urgency was seen with curcuminoids nanomicelles [39] and extra virgin olive oil [47]. Lack of abdominal pain was significantly associated with higher dietary daidzein and total isoflavones; however, there was no difference in abdominal pain with higher dietary proanthocyanidins [66].…”

“…Silymarin contains flavanolignans and significantly improved DAI at a dose of 240 mg/day for 6 months [49]. Bilberry anthocyanins (840 mg/day for 6 weeks) [44], flaxseed, and flaxseed oil (30 g/day and 10 g/day respectively for 12 weeks) [46] significantly reduced the Mayo score; however, extra virgin olive oil (50 mL/day for 20 days) had no effect [47]. Curcumin supplementation (3000 mg/day for 1 month) significantly reduced the partial Mayo score by ≥1 point [38].…”

“…The gastrointestinal symptom rating scale (GSRS) is a 15 item rating scale used to assess symptoms in IBD and peptic ulcer disease [80]. Consumption of extra virgin olive oil significantly reduced the GSRS in participants with UC [47]. One study investigating curcumin supplementation found a significant reduction in global score that considered general wellbeing, number and quality of stool, blood in stool, abdominal pain, rectal pain urgency, medication change, and endoscopy [43].…”

“…Lack of constipation was significantly associated with lower dietary glycitein [66] and higher dietary proanthocyaninidins were significantly associated with constipation [65]. Extra virgin olive oil administration resulted in a significant reduction in reports of constipation [47]. One study explored individual gastrointestinal symptoms in CD and found supplementation with Theracurmin significantly reduced stool frequency and demonstrated a trend in reduced abdominal pain [54].…”