The effects of exercise training on the kinetics of oxygen uptake in patients with chronic heart failure

Roditis, P.; Dimopoulos, Stavros; Sakellariou, D.; Sarafoglou, S.; Kaldara, Elisabeth; Venetsanakos, J.; Vogiatzis, J.; Anastasiou-Nana, Maria; Roussos, C.; Nanas, Serafim

doi:10.1097/01.hjr.0b013e32808621a3

Cited by 30 publications

(38 citation statements)

References 52 publications

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“…Similar to other studies (Freyssin et al 2012;Roditis et al 2007) employing 30 s HIIT intervals, we report no adverse events relating to the exercise intervention. As such, HIIT subsequent to 6 weeks of cardiovascular conditioning appears to be well-tolerated across fitness levels in ageing men.…”

Section: Discussionsupporting

confidence: 89%

Impact of low-volume, high-intensity interval training on maximal aerobic capacity, health-related quality of life and motivation to exercise in ageing men

Knowles

Herbert

Easton

et al. 2015

AGE

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There is a demand for effective training methods that encourage exercise adherence during advancing age, particularly in sedentary populations. This study examined the effects of high-intensity interval training (HIIT) exercise on health-related quality of life (HRQL), aerobic fitness and motivation to exercise in ageing men. Participants consisted of males who were either lifelong sedentary (SED; N=25; age 63±5 years) or lifelong exercisers (LEX; N=19; aged 61±5 years).V O 2max and HRQL were measured at three phases: baseline (Phase A), week seven (Phase B) and week 13 (Phase C). Motivation to exercise was measured at baseline and week 13.VO 2max was significantly higher in LEX (39.2±5.6 ml kg min −1 ) compared to SED (27.2 ±5.2 ml kg min −1 ) and increased in both groups from Phase A to C (SED 4.6±3.2 ml kg min −1 , 95 % CI 3.1 -6.0; LEX 4.9±3.4 ml kg min −1 , 95 % CI 3.1-6.6) Physical functioning (97±4 LEX; 93±7 SED) and general health (70±11 LEX; 78±11 SED) were significantly higher in LEX but increased only in the SED group from Phase A to C (physical functioning 17±18, 95 % CI 9-26, general health 14±14, 95 % CI 8-21). Exercise motives related to social recognition (2.4±1.2 LEX; 1.5 ±1.0 SED), affiliation (2.7±1.0 LEX; 1.6±1.2 SED) and competition (3.3±1.3 LEX; 2.2±1.1) were significantly higher in LEX yet weight management motives were significantly higher in SED (2.9±1.1 LEX; 4.3± 0.5 SED). The study provides preliminary evidence that low-volume HIIT increases perceptions of HRQL, exercise motives and aerobic capacity in older adults, to varying degrees, in both SED and LEX groups.Keywords Ageing men . High-intensity interval training . Health-related quality of life . Motivation . Exercise

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Section: Discussionsupporting

confidence: 89%

Impact of low-volume, high-intensity interval training on maximal aerobic capacity, health-related quality of life and motivation to exercise in ageing men

Knowles

Herbert

Easton

et al. 2015

AGE

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“…The ventilatory response to exercise was calculated as the slope by linear regression of V E versus V CO 2 from the beginning of exercise to AT as in previous studies. 10,15,18,20 Peak work rate was defined as the highest work level reached and maintained at a pedaling frequency of no less than 50 rpm for 20 s. Subjects were instructed to exercise until exhaustion. A respiratory exchange ratio Ͼ 1.09 was considered to be an indication of a nearly maximal effort.…”

Section: What This Paper Contributes To Our Knowledgementioning

confidence: 99%

“…Curve fitting was performed with Origin 7.0 graphics software (Microcal Software, Northampton, Massachusetts) using iterative techniques. 20 V O 2 response was described by a 3-phase model. 20,21 To characterize phase 1 (cardiodynamic phase), we used the period from the start of the exercise to the point when the respiratory exchange ratio started to fall in conjunction with end-tidal P O 2 starting to fall and end-tidal P CO 2 starting to increase.…”

Section: Constant Work Load Submaximal Cpetmentioning

confidence: 99%

“…Initially, the test load was set at 80% of the value of the work rate (WR) corresponding to the AT detected in the maximum test, which was performed first (with a minimum value of 30 W). 20,21 Cardiopulmonary data were recorded for 2 min at rest, followed by 3 min of unloaded pedaling. After unloaded pedaling, subjects performed the constant load test for 7 min at the work load rate described above, followed by unloaded pedaling for 5 min.…”

Section: Constant Work Load Submaximal Cpetmentioning

confidence: 99%

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Prolonged Oxygen Kinetics During Constant Workload Submaximal Exercise Is Associated With Disease Severity in Adult Subjects With Cystic Fibrosis

et al. 2015

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BACKGROUND:The goal of this study was to explore the relation between oxygen kinetics during constant work load submaximal cardiopulmonary exercise test (CPET) and disease severity in adult subjects with cystic fibrosis. METHODS: Fourteen adult subjects with cystic fibrosis (CF; 8 males, 22 ؎ 4 y old) and a mean Schwachman score of 73 ؎ 11 and 10 healthy individuals (5 males, 29 ؎ 4 y old) underwent pulmonary function tests at rest, maximal and constant work load submaximal CPET on a cycloergometer. Breath-by-breath analysis was used for measuring oxygen kinetic parameters and the time constant (tau), expressing phase 2 of submaximal CPET. RESULTS: Subjects with CF had a significantly prolonged tau compared with healthy subjects (42.3 ؎ 21.5 vs 29.3 ؎ 6.4, s, P < .05). The tau during phase 2 was inversely correlated with FEV 1 (% pred) (r ‫؍‬ ؊0.77, P ‫؍‬ .001), breathing reserve (r ‫؍‬ ؊0.74, P ‫؍‬ .003), V O2peak (r ‫؍‬ ؊0.53, P ‫؍‬ .049), V O2 /t slope (r ‫؍‬ ؊0.58, P ‫؍‬ .03), and Schwachman score (r ‫؍‬ ؊0.80, P ‫؍‬ .001). In a multivariate regression model including all the above variables, the Schwachman score (␤ ‫؍‬ ؊0.697, P ‫؍‬ .002) emerged as independent predictor of tau (R 2 ‫؍‬ 0.719, P ‫؍‬ .001). CONCLUSIONS: We conclude that adult subjects with CF present significant prolonged oxygen kinetics during constant work load submaximal exercise in relation to disease severity. Thus, submaximal exercise should be considered the preferable CPET choice in adult patients with severe CF.

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“…Also, it reduces inflammatory markers in plasma and peripheral muscles [5] and improves the kinetics of oxygen uptake [6]. Exercise training has been used in CHF patients with favorable outcome.…”

Section: Introductionmentioning

confidence: 99%

Interval exercise training improves tissue oxygenation in patients with chronic heart failure

Vasileiadis¹,

Kravari²,

Terrovitis³

et al. 2013

WJCD

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Aim: Aim of our study was to evaluate the effects of interval exercise training (IT) programs, regarding whole body oxygen uptake and peripheral tissue oxygenation, in Chronic Heart Failure (CHF) patients during recovery. Methods: Twenty-six CHF patients (21 males/5 females), mean age of 49 ± 12 years, participated in the study. Fifteen patients were assigned to IT and 11 patients were assigned to IT followed by strength training. All patients were trained for 40 minutes per session, 3 times per week, for 12 weeks. They performed a symptom-limited cardiopulmonary exercise testing (CPET), before and after the completion of the program. Muscle tissue oxygen saturation (StO 2 ) of quadriceps femoris was continuously measured by Near Infrared Spectroscopy (NIRS) during CPET and during the recovery period after the end of exercise. Results: No differences were noted between the two patient groups regarding whole body and peripheral tissue oxygenation indices and, therefore, data from all patients were pooled. After training, an increase in peak oxygen uptake (17 ± 4.5 to 19 ± 5.5 ml/kg/min, p < 0.05), gas exchange threshold (11 ± 3.5 to 12.5 ± 3.5 ml/kg/min, p < 0.05), peak work rate achieved (105 ± 29 to 124 ± 37 Watt, p < 0.05) and the first degree slope of VO 2 at the first minute of recovery (0.45 ± 0.2 to 0.61 ± 0.3 L/min 2 , p < 0.05), was noted. In addition, tissue re-oxygenation time constant was decreased (65 ± 25 to 52 ± 28 sec, p < 0.001). Conclusion: In conclusion, interval exercise training accelerates oxygen uptake and peripheral tissue oxygenation during recovery from exercise in CHF patients.

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The effects of exercise training on the kinetics of oxygen uptake in patients with chronic heart failure

Abstract: Exercise training improves O2 kinetics in chronic heart failure patients. Both continuous and interval training improve phase I O2-kinetics, but continuous training results in superior improvement of the phase II O2-kinetics, an indirect index of muscle oxidative capacity.

Cited by 30 publications

References 52 publications

Impact of low-volume, high-intensity interval training on maximal aerobic capacity, health-related quality of life and motivation to exercise in ageing men

Impact of low-volume, high-intensity interval training on maximal aerobic capacity, health-related quality of life and motivation to exercise in ageing men

Prolonged Oxygen Kinetics During Constant Workload Submaximal Exercise Is Associated With Disease Severity in Adult Subjects With Cystic Fibrosis

Interval exercise training improves tissue oxygenation in patients with chronic heart failure

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