The Effects of Exercise Preconditioning on Cerebral Blood Flow Change and Endothelin-1 Expression after Cerebral Ischemia in Rats

Zhang, Qi; Zhang, Li; Yang, Xiaojiao; Wan, Yonggan; Jia, Jie

doi:10.1016/j.jstrokecerebrovasdis.2014.01.016

Cited by 31 publications

(18 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, early and more frequent exercise within the first 6 months after stroke is associated with improved mobility, greater independence, and reduced disability (Egan et al, 2014). Physical exercise improves stroke outcomes via multiple mechanisms, including mitigation of inflammatory responses, attenuation of apoptosis, enhancement of angiogenesis, neurogenesis and even synaptogenesis, improvements in cerebral blood circulation, inhibition of glutamate over-activation, and strengthening of brain microvascular integrity (Zhang et al, 2014c). …”

Section: Management and Treatmentmentioning

confidence: 99%

White matter injury in ischemic stroke

Wang

Liu

Hong

et al. 2016

Progress in Neurobiology

222

206

View full text Add to dashboard Cite

Stroke is one of the major causes of disability and mortality worldwide. It is well known that ischemic stroke can cause gray matter injury. However, stroke also elicits profound white matter injury, a risk factor for higher stroke incidence and poor neurological outcomes. The majority of damage caused by stroke is located in subcortical regions and, remarkably, white matter occupies nearly half of the average infarct volume. Indeed, white matter is exquisitely vulnerable to ischemia and is often injured more severely than gray matter. Clinical symptoms related to white matter injury include cognitive dysfunction, emotional disorders, sensorimotor impairments, as well as urinary incontinence and pain, all of which are closely associated with destruction and remodeling of white matter connectivity. White matter injury can be noninvasively detected by MRI, which provides a three-dimensional assessment of its morphology, metabolism, and function. There is an urgent need for novel white matter therapies, as currently available strategies are limited to preclinical animal studies. Optimal protection against ischemic stroke will need to encompass the fortification of both gray and white matter. In this review, we discuss white matter injury after ischemic stroke, focusing on clinical features and tools, such as imaging, manifestation, and potential treatments. We also briefly discuss the pathophysiology of WMI and future research directions.

show abstract

Section: Management and Treatmentmentioning

confidence: 99%

White matter injury in ischemic stroke

Wang

Liu

Hong

et al. 2016

Progress in Neurobiology

222

206

View full text Add to dashboard Cite

show abstract

“…Some emerging studies are utilizing histologic correlations to assess subsurface sensitivity to large flow changes. 67 However, ICTs, and to some extent speckle contrast values, are still commonly interpreted as RBC speed, 62 but the physical reality and manner of multiple dynamic scattering will likely affect the interpretation. However, without detailed characterization of the specimen-specific three-dimensional vascular architecture, 16 the exact physical relationship of ICTs to both blood volume and absolute flow may remain confounding.…”

Section: Disadvantagesmentioning

confidence: 99%

Expanding Applications, Accuracy, and Interpretation of Laser Speckle Contrast Imaging of Cerebral Blood Flow

Kazmi

Richards

Schrandt

et al. 2015

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

Laser speckle contrast imaging (LSCI) provides a rapid characterization of cortical flow dynamics for functional monitoring of the microcirculation. The technique stems from interactions of laser light with moving particles. These interactions encode the encountered Doppler phenomena within a random interference pattern imaged in widefield, known as laser speckle. Studies of neurovascular function and coupling with LSCI have benefited from the real-time characterization of functional dynamics in the laboratory setting through quantification of perfusion dynamics. While the technique has largely been relegated to acute small animal imaging, its scalability is being assessed and characterized for both chronic and clinical neurovascular imaging.

show abstract

“…Animal studies have indicated beneficial effects of preconditioning exercise on cerebral ischemia, including neurogenesis, maintenance of BBB and neurovascular integrity, enhanced cell survival rates and instruct protective factors, decreased excitatory system activation, and ameliorated inflammatory response 16,26,[32][33][34][35] (Figure 1).…”

Section: Potential Mechanisms Of Preconditioning Exercise On Neuropromentioning

confidence: 99%

“…This association of astroglial proliferation and angiogenesis with preconditioning exercise suggests that both astrocytes and endothelial cells participate in the formation of new blood vessels in the brain. Preconditioning exercise protects the brain from ischemia through improved cerebral blood flow and regulation of endothelin 1 (ET-1) in a rat model of ischemia 34) . Also, physical exercise increases levels of insulin-like growth factor 1 (IGF-1) and vascular endothelial growth factor (VEGF) in the serum or brain 9,25,45) .…”

Section: Preconditioning Exercise and Neurovascular Integritymentioning

confidence: 99%

Endogenous neuroprotective potential due to preconditioning exercise in stroke

Sakakima

2019

Phys Ther Res

View full text Add to dashboard Cite

Stroke is a leading cause of serious long-term physical disability due to insufficient neurorepair mechanisms. In general, physical activity is an important modifiable risk factor, particularly for stroke and cardiovascular diseases. Physical exercise has shown to be neuroprotective in both animal experiments and clinical settings. Exercise can be considered a mild stressor and follows the prototypical preconditioning stimulus. It has beneficial effects on brain health and cognitive function. Preconditioning exercise, which is prophylactic exercise prior to ischemia, can protect the brain from subsequent serious injury through promotion of angiogenesis, mediation of inflammatory responses, inhibition of glutamate over-activation, protection of the blood-brain barrier, and inhibition of apoptosis. Preconditioning exercise appears to induce brain ischemic tolerance and it has been shown to exert beneficial effects. It is clinically safe and feasible and represents an exciting new paradigm in endogenous neuroprotection for patients with acute stroke. In this review, we describe the neuroprotective potential of preconditioning exercise and clinical applications in patients with acute ischemic stroke.

show abstract

The Effects of Exercise Preconditioning on Cerebral Blood Flow Change and Endothelin-1 Expression after Cerebral Ischemia in Rats

Cited by 31 publications

References 35 publications

White matter injury in ischemic stroke

White matter injury in ischemic stroke

Expanding Applications, Accuracy, and Interpretation of Laser Speckle Contrast Imaging of Cerebral Blood Flow

Endogenous neuroprotective potential due to preconditioning exercise in stroke

Contact Info

Product

Resources

About