The effects of ethoxyquin and Angelica sinensis extracts on lipid oxidation in fish feeds and growth, digestive and absorptive capacities and antioxidant status in juvenile red carp (Cyprinus carpio var. xingguonensis): a comparative study

Li, Huatao; Tang, Siyi; Du, Wenhao; Jiang, Jun; Peng, PeiYuan; Yuan, Ping; Liao, YiHong; Long, Jiao; Zhou, SiShun

doi:10.1007/s10695-018-0533-x

Cited by 14 publications

(10 citation statements)

References 60 publications

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“…Our investigations underscored that dietary EAE counteracted the diminished activity of GPx and CAT in the carp’s red blood corpuscles upon exposure to hypoxia–reoxygenation. This observation resonates with previous findings, indicating enhanced activity of antioxidant enzymes in the hepatopancreas and intestines of fish supplemented with AsE [ 24 ]. Serving as a primary non-enzymatic antioxidant, GSH directly neutralizes intracellular ROS [ 44 ].…”

Section: Discussionsupporting

confidence: 93%

“…Based on research findings, the inclusion of Angelica sinensis extract (AsE) in fish diets appears to hinder ROS and lipid oxidation. Dietary AsE enhances the capacity of enzymatic antioxidants in the hepatopancreas and intestines of fish [ 23 , 24 , 25 ]. Furthermore, in China, the production of Angelica sinensis has reached 80,000 tons [ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

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The Extract of Angelica sinensis Inhibits Hypoxia–Reoxygenation and Copper-Induced Oxidative Lesions and Apoptosis in Branchiae and Red Blood Corpuscles of Fish

Long,

Yang,

Liu

et al. 2023

Veterinary Sciences

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The study explored the effects of Angelica sinensis extract (AsE) on oxidative lesions and apoptosis in branchiae and red blood corpuscles in hypoxia–reoxygenation (HR) and Cu-treated carp (Cyprinus carpio var. Jian). After feeding trial for 30 days, the carp were exposed to HR and CuSO4. The results indicated that dietary AsE increased the durative time, decreased the oxygen consumption rate, suppressed ROS generation and cellular component oxidation, decreased enzymatic antioxidant activity and reduced glutathione (GSH) levels in red blood corpuscles and branchiae in carp under hypoxia. Moreover, dietary AsE avoided the loss of Na+,K+-ATPase, metabolic and antioxidant enzyme activities, ROS generation and cellular component oxidation, as well as the increase in caspase-8, 9, and 3 activities in the branchiae of the carp and inhibited ROS generation. It furthermore avoided the loss of Na+,K+-ATPase and metabolic enzyme activities, the decrease in GSH levels and hemoglobin content, the increase in the activities of caspase-8, 9, and 3 and the increase in the levels of cytochrome c and phosphatidylserine exposure in the red blood corpuscles of Cu-exposed carp. The present results suggested that dietary AsE improved hypoxia tolerance and inhibited HR or Cu-triggered oxidative lesions and apoptosis. Therefore, AsE can be utilized as a natural inhibitor of Cu and HR stress in fish.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

The Extract of Angelica sinensis Inhibits Hypoxia–Reoxygenation and Copper-Induced Oxidative Lesions and Apoptosis in Branchiae and Red Blood Corpuscles of Fish

Long,

Yang,

Liu

et al. 2023

Veterinary Sciences

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“…Fish cells are equipped with antioxidant enzymes that are responsible for neutralizing intracellular reactive oxygen species (ROS) and preventing the oxidation of the cellular components, as referenced in [ 62 , 63 ]. GSH, which serves as a primary non-enzymatic antioxidant, plays a crucial role in directly scavenging intracellular ROS [ 64 ]. Additionally, GST facilitates the conjugation of lipid peroxide breakdown products using GSH as a substrate [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Ferulic Acid on Respiratory Metabolism, Oxidative Lesions, and Apoptotic Parameters in Gills and Red Blood Cells of Carp (Cyprinus carpio Var. Jian) Response to Copper

Li,

Liu,

et al. 2024

Antioxidants

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In sustainable aquaculture systems, copper sulfate (CuSO4) is widely applied as a disinfectant to control parasitic infections and algal growth. However, aquatic organisms may suffer from exposure to excessive concentrations of Cu. Elevated Cu concentrations could activate damage to the respiratory functions of aquatic animals. Thus, this study explored the effects exerted by ferulic acid (FA) on respiratory metabolism, oxidation-related lesions, and the apoptosis parameters of the gills and red blood cells in copper sulfate pentahydrate (CuSO4·5H2O)-treated carp (Cyprinus carpio var. Jian). When the 30-day feeding experiment was completed, the carp were exposed to 12.5 μM of Cu for 4 days. The results indicated that the Cu decreased the oxygen consumption and ammonia excretion rates in the carp, reduced the metabolic- and antioxidant-related enzyme activities and glutathione levels in the carp, and enhanced the caspase activities and reactive oxygen species and malondialdehyde levels in the gills of the carp. Moreover, in addition to the changes in the above parameters, the Cu decreased the cell numbers and hemoglobin concentrations and increased the phosphatidylserine exposure and cytochrome c levels in the red blood cells of the carp. These results demonstrate that Cu is capable of decreasing respiratory metabolism and increasing oxidation-related lesions and apoptosis inside the gills and red blood cells of the fish. However, dietary FA quenched the Cu-induced apoptosis and oxidative lesions by reversing the same biomarker indicators, thereby suppressing the Cu-induced decrease in respiratory metabolism. Thus, FA can be used as a suppressor of Cu stress in fish.

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“…In red carp, Cyprinus carpio var. xingguonensis, the dietary inclusion of Angelica sinensis extracts increased the intestine and hepatopancreas antioxidant capacity by increasing SOD, catalase, GR, and GPX activities, while LPO was decreased [48]. In rainbow trout, Oncorhynchus mykiss, dietary supplementation with different phytobiotics (rosemary; R. officinalis; sea buckthorn, Hippophae rhamnoides; and ginger, Zinziber…”

Section: Discussionmentioning

confidence: 99%

Application of Fermented Brewer’s Spent Grain Extract in Plant-Based Diets Improves Pre- and Post-mortem Oxidative Status of European Seabass (Dicentrarchus labrax)

Fernandes

Castro

Filipe

et al. 2022

Aquaculture Nutrition

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In a previous study, it was shown that dietary supplementation with a carbohydrases and antioxidant-enriched extract (BSG-extract) produced by solid-state fermentation of brewer’s spent grain (BSG) improved nutrients digestibility, feed, and protein utilization of European seabass juveniles. This work aims to investigate the effect of this BSG-extract on liver and intestine oxidative status and muscle lipid peroxidation (LPO) of European seabass. A plant-based diet (55.4% plant feedstuffs; PF) was used as a control. Four test diets were formulated by supplementing the control diet with the BSG-extract (0.4 or 0.8% diet), added directly to the diet (BSG4 and BSG8 diets), or used to pre-treat the PF mixture of the control diet (PreBSG4 and PreBSG8 diets). European seabass juveniles (IBW 22 ± 1 g) were fed the experimental diets for 66 days until apparent satiety. In fish fed BSG-extract diets, compared to the control diet, intestinal LPO was reduced up to 29-40% ( p < 0.05 ); GPX, GR, and G6PD activities were increased compared to the control ( p < 0.05 ). In the liver, LPO was similar among diets, but except for catalase and G6PD, fish fed BSG-extract diets had higher antioxidant enzyme activities than the control ( p < 0.05 ). Except for the liver SOD activity, hepatic and intestinal antioxidant capacity was not affected by the dietary BSG-extract incorporation mode ( p > 0.05 ). After 72 h of storage at 4°C, muscle LPO was higher than at time 0 h. Compared to the control, BSG-extract reduced muscle LPO levels up to 30% at time 0 h in fish fed diets BSG4, BSG8, and PreBSG8 ( p < 0.008 ). Results indicate that dietary supplementation with BSG-extract increased the antioxidant level of diets, improved the intestine antioxidant capacity, and decreased LPO in European seabass juveniles’ muscle.

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The effects of ethoxyquin and Angelica sinensis extracts on lipid oxidation in fish feeds and growth, digestive and absorptive capacities and antioxidant status in juvenile red carp (Cyprinus carpio var. xingguonensis): a comparative study

Cited by 14 publications

References 60 publications

The Extract of Angelica sinensis Inhibits Hypoxia–Reoxygenation and Copper-Induced Oxidative Lesions and Apoptosis in Branchiae and Red Blood Corpuscles of Fish

The Extract of Angelica sinensis Inhibits Hypoxia–Reoxygenation and Copper-Induced Oxidative Lesions and Apoptosis in Branchiae and Red Blood Corpuscles of Fish

Effects of Ferulic Acid on Respiratory Metabolism, Oxidative Lesions, and Apoptotic Parameters in Gills and Red Blood Cells of Carp (Cyprinus carpio Var. Jian) Response to Copper

Application of Fermented Brewer’s Spent Grain Extract in Plant-Based Diets Improves Pre- and Post-mortem Oxidative Status of European Seabass (Dicentrarchus labrax)

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