The effects of ethanol methotrexate and diphenylhydantoin on [¹⁴C] leucine incorporation by human trophoblast cells cultured in vitro

Abstract

Summary. The effects of alcohol, diphenylhydantoin and methotrexate on protein synthesis by human trophoblast have been studied in vitro using a cell culture technique. None of the drugs depressed protein synthesis at pharmacological levels and for diphenylhydantoin there was evidence that the cellular accumulation of this drug was negligible.