The effects of estrogen on apomorphine-induced hypothermia and stereotypy in the rat

Pittman, K; Fibiger, Hans C.

doi:10.1016/0028-3908(83)90149-1

Cited by 17 publications

(3 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Estradiol treatment decreases the apomorphine-induced circling in rats with lesions of the entopeduncular nucleus (61). Large estradiol doses attenuate apomorphine-induced stereotypy in the rat (62). Chronic estrogen treatment in ovariectomized rats decreases dopamine concentration in the striatum (63).…”

Section: Anti-dopaminergic Effects Of Estrogen On the Dopaminergic Symentioning

confidence: 96%

Estrogen and Parkinson s disease

Kompoliti¹

2003

Front Biosci

View full text Add to dashboard Cite

Female sex hormones, and more specifically estrogen, can have biochemical and behavioral effects on the dopaminergic system. The effects of estrogen on the dopaminergic system can be classified as either neuroprotective or symptomatic. The neuroprotective effects refer to the ability of estrogen to prevent or modulate insults to the dopaminergic system and therefore to alter the natural history of disease processes affecting the dopaminergic circuitry in the brain. With regards to the symptomatic effects, support for both suppressive and enhancing effects has been documented in humans and laboratory animals. The pre-clinical literature for neuroprotective and symptomatic effects of estrogen on the mesostriatal dopaminergic system forms the basis for studies on the influence of estrogen on the prevalence, disease progression, clinical signs, and medication effects of Parkinson's disease and other movement disorders. Understanding the role of estrogen in modulating the dopaminergic system will allow clinicians to tailor therapies for women with Parkinson's disease and optimize therapies for menstrually related symptom fluctuations. Such clarifications may also guide recommendations on the use of postmenopausal hormonal replacement therapy in women with Parkinson's disease or those genetically at risk.

show abstract

Section: Anti-dopaminergic Effects Of Estrogen On the Dopaminergic Symentioning

confidence: 96%

Estrogen and Parkinson s disease

Kompoliti¹

2003

Front Biosci

View full text Add to dashboard Cite

show abstract

“…One of these is the locomotor response to psychostimulants such as amphetamine and cocaine (Peris et al, 1991;Pittman & Fibiger, 1983;Sell et al, 2000;Sircar & Kim, 1999). Repeated administration of psychostimulants results in a progressive increase in locomotion, referred to as sensitization.…”

Section: Introductionmentioning

confidence: 99%

“…In the female, the gonadal hormone estrogen modulates many behaviors and physiological processes besides those associated with reproduction (Segarra & Lee, 2004). One of these is the locomotor response to psychostimulants such as amphetamine and cocaine (Peris, Decambre, Coleman-Hardee, & Simpkins, 1991; Pittman & Fibiger, 1983; Sell, Scalzitti, Thomas, & Cunningham, 2000; Sircar & Kim, 1999). Repeated administration of psychostimulants results in a progressive increase in locomotion, referred to as sensitization.…”

mentioning

confidence: 99%

U-69593, a kappa opioid receptor agonist, decreases cocaine-induced behavioral sensitization in female rats.

Puig-Ramos

Santiago²,

Segarra³

2008

Behavioral Neuroscience

View full text Add to dashboard Cite

This study was designed to investigate if the kappa opioid system regulates the locomotor response to cocaine in the female rat and to determine if the effect is dependent on estradiol treatment. Adult rats were ovariectomized (OVX) and half received an estradiol (OVX-EB) implant. After a week, rats were injected for 5 consecutive days with vehicle or with the KOPr agonist U-69593 (0.16 mg/ kg, 0.32 mg/kg, 0.64 mg/kg) 15 min prior to cocaine injection (15 mg/kg). Following a 7 day drug free period, rats were challenged with cocaine (Day 13). The locomotor response to cocaine was measured on days 1, 5 and 13. U-69593 (0.32 mg/kg) decreased cocaine-induced locomotor activity in drug naïve OVX and OVX-EB rats. These results indicate that the acute effects of U-69593 are independent of estradiol treatment. Repeated exposure to U-69593 (0.32 mg/kg) prior to cocaine decreased the development of behavioral sensitization in OVX-EB rats. This decrease in cocaine-induced hyperlocomotion persisted after one week of cocaine withdrawal. These data indicate that the KOPr system participates in estradiol modulation of cocaine-induced behavioral sensitization in the female rat.

show abstract

Dopaminergic regulation of striatal cholinergic interneurons: an in vivo microdialysis study

Damsma

Deboer

Westerink

et al. 1990

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

In vivo microdialysis was used to study the putative inhibitory effects of dopamine on cholinergic interneurons in the striatum of conscious rats. The dopamine receptor agonists apomorphine (0.3 and 3 mg/kg, s.c.) and (+/-)N-0437 (1.4 mg/kg, s.c. decreased interstitial concentrations of acetylcholine while increasing those of choline. In contrast, the dopamine receptor antagonists haloperidol (0.1 and 1 mg/kg, i.p.) and (+/-)sulpiride (20 mg/kg, i.p.) enhanced striatal acetylcholine output but had little effect on choline. Previously, a lack of effect of these drugs on striatal acetylcholine was reported. The main methodological difference between these studies was that the calcium concentration of the microdialysis perfusion solution was 3.4 mM in the former study versus 1.2 mM in the present experiments. The results of this study reemphasize the importance of the calcium concentration in determining the effects of drugs on central neurotransmitter release, and confirm a role of dopamine in the regulation of striatal cholinergic interneurons.

show abstract

The effects of estrogen on apomorphine-induced hypothermia and stereotypy in the rat

Cited by 17 publications

References 39 publications

Estrogen and Parkinson s disease

Estrogen and Parkinson s disease

U-69593, a kappa opioid receptor agonist, decreases cocaine-induced behavioral sensitization in female rats.

Dopaminergic regulation of striatal cholinergic interneurons: an in vivo microdialysis study

Contact Info

Product

Resources

About