The effects of equine somatotropin (eST) on follicular development and circulating plasma hormone profiles in cyclic mares treated during different stages of the estrous cycle

Cochran, R.; Leonardi-Cattolica, A.A.; Sullivan, M.R.; Kincaid, Lori A.; Leise, Britta S.; Thompson, Donald L.; Godke, R.A.

doi:10.1016/s0739-7240(98)00046-0

Cited by 28 publications

(10 citation statements)

References 34 publications

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“…In addition, follistatin binds and inactivates activin, a potent stimulator of preantral follicle growth in vitro (Liu et al 1998). In vivo, GH administration increased the number of small preantral follicles in cattle (Gong et al 1991(Gong et al , 1993 and horses (Cochran et al 1999). Moreover, GH-binding activity was highest in granulosa cells of preantral follicles compared with large antral follicles in porcine and fish ovaries (Gomez et al 1999, Quesnel 1999, suggesting that GH is important for preantral follicular growth, possibly through increasing ovarian activin production (Liu et al 1998).…”

Section: Discussionmentioning

confidence: 99%

Reduced recruitment and survival of primordial and growing follicles in GH receptor-deficient mice

Slot

Kastelijn²,

Bachelot³

et al. 2006

Reproduction

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GH influences female fertility. The goal of the present study was to obtain more insight into the effect of loss of GH signalling, as observed in humans suffering from Laron syndrome, on ovarian function. Therefore, serial paraffin sections of ovaries of untreated and IGF-I-treated female GH receptor knock-out (GHR/GHBP-KO) mice were examined to determine the follicular reserve and the percentage of follicular atresia in each ovary. Our observations demonstrate that the amount of primordial follicles was significantly elevated in GHR/GHBP-KO mice, while the numbers of primary, preantral and antral follicles were lower compared with wild-type values. The reduced number of healthy growing follicles in GHR/GHBP-KO mice was accompanied by a significant increase in the percentage of atretic follicles. IGF-I treatment of GHR/GHBP-KO mice for 14 days resulted in a reduced number of primordial follicles, an increased number of healthy antral follicles, and a decreased percentage of atretic follicles. The results of the present study suggest that GH may play a role, either directly or indirectly, via for instance IGF-I, in the recruitment of primordial follicles into the growing pool. Furthermore, GH seems to protect antral follicles, directly or indirectly from undergoing atresia. Reproduction (2006) 131 525-532

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Section: Discussionmentioning

confidence: 99%

Reduced recruitment and survival of primordial and growing follicles in GH receptor-deficient mice

Slot

Kastelijn²,

Bachelot³

et al. 2006

Reproduction

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“…In marked contrast, the failure to develop a reliable protocol for pharmacologically inducing multiple ovulation in mares was a major reason for the delayed adoption of ET in equine practice (Squires et al 1999). Although many ovarian stimulatory treatments were tested in mares, few yielded more than an approximate doubling of the ovulation rate (for review see McCue 1996); treatments examined included eCG (Day 1940), GnRH (Ginther and Bergfelt 1990), porcine pituitary FSH preparations (Fortune and Kimmich 1993), growth hormone (Hofferer et al 1991;Cochran et al 1999), equine pituitary gonadotrophin extract (EPE: Douglas et al 1974;Hofferer et al 1991;Dippert et al 1992) and both active (McKinnon et al 1992) and passive (McCue et al 1993) immunisation against inhibin.…”

Section: Multiple Ovulationmentioning

confidence: 99%

Equine embryo transfer: review of developing potential

Stout

2010

Equine Veterinary Journal

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“…l Higher magnification of the wall in k (asterisks lack of staining in the theca externa). Bars100 μm (a, b, d), 50 μm (e, g, h, j, k), 20 μm (c, f, i, l, inset in a) ulates the growth of small ovarian follicles in chicken (Williams et al 1992), and that it also stimulates the growth and prevents the atresia of small follicles in cattle (Gong et al 1993), horses (Cochran et al 1999), and mice (Kobayashi et al 2000) and increases the number of large follicles in the ovaries of rats (Ozawa et al 1996) and cows (De laSota et al 1993). The high expression of GH in the granulosa layer of the hen ovarian follicles might also be associated with progesterone production (Rząsa et al 1997), which in turn is responsible for the final maturation and ovulation of the largest follicles as observed in rats (Apa et al 1994), rabbits (Yoshimura et al 1993), pigs (Hagen and Graboski 1990), and cows (Izadyar et al 1996;Kölle et al 2003).…”

Section: Discussionmentioning

confidence: 99%

Expression and localization of growth hormone and its receptors in the chicken ovary during sexual maturation

et al. 2008

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Roles of pituitary growth hormone (GH) in female reproduction are well established. Autocrine and/or paracrine actions of GH in the mammalian ovary have additionally been proposed, although whether the ovary is an extra-pituitary site of GH expression in the laying hen is uncertain. This possibility has therefore been assessed in the ovaries of Hy-Line hens before (between 10-16 weeks of age) and after (week 17) the onset of egg laying. Reverse transcription/polymerase chain reaction (RT-PCR) analysis has consistently detected a full-length (690 bp) pituitary GH cDNA in ovarian stroma from 10 weeks of age, although GH expression is far lower than that in the pituitary gland or hypothalamus. GH mRNA is also present in small (>1-4 mm diameter) follicles after their ontogenetic appearance at 14 weeks of age and in all other developing follicles after 16 weeks of age (>4-30 mm diameter). Immunoreactivity for GH is similarly present in the ovarian stroma from 10 weeks of age and in small (<4 mm diameter) and large (>4-30 mm) follicles from 14 and 16 weeks of age, respectively. The relative intensity of GH staining in the ovarian follicles is consistently greater in the granulosa cells than in the thecal cells and is comparable with that in the follicular epithelium. A 321-bp fragment of GH receptor (GHR) cDNA, coding for the intracellular domain of the receptor, has also been detected by RT-PCR in the ovary and is present in stromal tissue by 10 weeks of age, in small follicles (<4 mm diameter) by 14 weeks of age, and in larger follicles (>4-30 mm diameter) from 16 weeks. GHR immunoreactivity has similarly been detected, like GH, in the developing ovary and in all follicles and is more intense in granulosa cells than in the theca interna or externa. The expression and location of the GH gene therefore parallels that of the GHR gene during ovarian development in the laying hen, as does the appearance of GH and GHR immunoreactivity. These results support the possibility that GH has autocrine and/or paracrine actions in ovarian function prior to and after the onset of lay in hens.

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The effects of equine somatotropin (eST) on follicular development and circulating plasma hormone profiles in cyclic mares treated during different stages of the estrous cycle

Cited by 28 publications

References 34 publications

Reduced recruitment and survival of primordial and growing follicles in GH receptor-deficient mice

Reduced recruitment and survival of primordial and growing follicles in GH receptor-deficient mice

Equine embryo transfer: review of developing potential

Expression and localization of growth hormone and its receptors in the chicken ovary during sexual maturation

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