The effects of epinephrine and dobutamine on skin flap viability in rats: A randomized double-blind placebo-controlled study

Krammer, Caspar Weel; Ibrahim, Rami Mossad; Hansen, Tom Giedsing; Sørensen, Jens Ahm

doi:10.1016/j.bjps.2014.09.044

Cited by 14 publications

(7 citation statements)

References 37 publications

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“…Rat studies have shown that intraperitoneal epinephrine tends to decrease skin flap survival by causing vasoconstriction. 22 …”

Section: Discussionmentioning

confidence: 99%

“…Rat studies have shown that intraperitoneal epinephrine tends to decrease skin flap survival by causing vasoconstriction. 22 Conservative debridement was performed on twin B to prevent the brain from protruding, and cadaveric skin allograft was used as biological cover to prevent desiccation and wound dehiscence. Cadaveric allograft skin has been used in extensive burn patients where donor area is limited.…”

Section: Discussionmentioning

confidence: 99%

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First Successful Separation of Craniopagus Twins in India—Plastic Surgical Considerations

Singhal

Sabapathy

Gupta

et al. 2022

Indian J Plast Surg

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Separation of total vertical craniopagus with shared venous sinuses poses multiple challenges. Provision of soft-tissue cover to the exposed brains at the time of total separation is one of them, due to the large size of the defect and paucity of local tissues. Staged separation of twins is advised with partial venous and parenchymal disconnection in the first stage and total separation in the second stage. Tissue expanders are inserted in the first stage, and second stage planned to coincide with the period of adequate expansion. In the child being reported, emergency second stage was done due to the deteriorating general condition of the children. Left with inadequate expanded skin, the critical defect in a twin was managed with bilateral trapezius myocutaneous flaps. High ionotropic support of the postoperative period resulted in superficial necrosis of the flap, which was managed by debridement, allograft application and autograft later. Both twins had well-healed wounds by 3 months.

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“…Rat studies have shown that intraperitoneal epinephrine tends to decrease skin flap survival by causing vasoconstriction. 22 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

First Successful Separation of Craniopagus Twins in India—Plastic Surgical Considerations

Singhal

Sabapathy

Gupta

et al. 2022

Indian J Plast Surg

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“…Blood vessels to the flap are cut off and perfusion pressure drops significantly in the distal flap, resulting in an ischemic state.(Y. S. Krammer et al, 2015) In this study, BoNT-A was used as a pharmacological adjuvant therapy to increase flap viability. The mechanism is thought to affect the cutaneous autonomic sympathetic nervous system via suppression of sympathetic neurons.…”

Section: Effects Of Bont-a On Sympathetic Neurotransmittersmentioning

confidence: 99%

Administration of botulinum toxin a and vascular endhotelial growth factor reduce norepinephrine levels and increase viability of modified mcfarlane flap in wistar rat

Purwanthi

Hamid

Mahadewa

et al. 2022

ijhs

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Local hyperadrenergic states after a random flap elevation mediated by humoral vasoconstrictors can lead to flap necrosis. This study aimed to evaluate the effect of Botulinum Toxin A (BoNT-A) on reducing levels of Norepinephrine (NE) as the main humoral vasoactive substance, as well as its additive effect with Vascular Endothelial Growth Factor (VEGF) in increasing the viability of random flap. 28 Wistar Rats with Caudally Based Modified McFarlane Flap were divided into four groups. Group I received BoNT-A 3 days before flap elevation, group II received VEGF immediately after flap elevation, group III received a combination of BoNT-A and VEGF, group IV was a control group. Result in this study NE levels lowest was found in the BoNT-A+VEGF combination group (94.63 ± 5 .25 ng/ml, p<0.05 in group I, p<0.01 in groups II and IV). The highest value of FVR was shown in the BoNT-A+VEGF combination group (93.37 ± 2.19 %, p < 0.05 in group I, p < 0.01 in groups II and IV). Meanwhile, the increase in flap viability in the VEGF group was not statistically significant. So Conclusion administration of BoNT-A in combination with VEGF can increase the viability of random flaps by decreasing NE levels.

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“…4 Only one article described its randomization methodology, and had both allocation concealment and blinding of the primary outcome. 5 Only two of the authors contacted who mentioned randomization responded and described their methodology. The remaining findings are in Table 1.…”

Section: Of 154 Articles Met the Inclusion Criteria (Appendix 1)mentioning

confidence: 99%

Laboratory animal research published in plastic surgery journals in 2014 has extensive waste: A systematic review

Freshwater

2015

Journal of Plastic, Reconstructive & Aesthetic Surgery

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The effects of epinephrine and dobutamine on skin flap viability in rats: A randomized double-blind placebo-controlled study

Cited by 14 publications

References 37 publications

First Successful Separation of Craniopagus Twins in India—Plastic Surgical Considerations

First Successful Separation of Craniopagus Twins in India—Plastic Surgical Considerations

Administration of botulinum toxin a and vascular endhotelial growth factor reduce norepinephrine levels and increase viability of modified mcfarlane flap in wistar rat

Laboratory animal research published in plastic surgery journals in 2014 has extensive waste: A systematic review

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