The effects of electroconvulsive therapy on ghrelin, leptin and cholesterol levels in patients with mood disorders

Kurt, Erhan; Güler, Özkan; Serteser, Mustafa; Cansel, Neslihan; Özbulut, Ömer; Altınbaş, Kürşat; Alataş, Gazi; Savaş, Haluk A.; Geçici, Ömer

doi:10.1016/j.neulet.2007.08.018

Cited by 55 publications

(39 citation statements)

References 23 publications

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“…We also reported that an antidepressant-like effect of antisense DNA for ghrelin in rats suggests a depressogenic effect [42]. This view receives some support from studies reporting that psychopathological improvement of depressed patients following electroconvulsive therapy [60] and psychopharmacological treatment [61,62] was associated with a decrease in ghrelin plasma levels. However, one study reported an increase during antidepressant medication [63].…”

Section: Discussionmentioning

confidence: 72%

“…Astonishingly little is known about the effects of long-term ghrelin exposure on these behaviors, forming a key aim of the present study. Even though genetic and pharmacological studies suggest that ghrelin is of clinical relevance for psychiatric conditions such as mood disorders in humans [47,60,61], contradictory data have been published as well [68,69]. …”

Section: Discussionmentioning

confidence: 99%

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Serum Ghrelin Levels and the Effects of Antidepressants in Major Depressive Disorder and Panic Disorder

Ishitobi

Kohno²,

Kanehisa³

et al. 2012

Neuropsychobiology

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Background: Two opposing models for the action of ghrelin in the behavioral responses to stress were recently proposed. Some studies suggest that an increase in ghrelin contributes to the mechanisms responsible for the development of stress-induced depression and anxiety, while others suggest that it helps minimize what otherwise would be more severe manifestations of depression and anxiety following stress. Methods: We measured serum ghrelin levels, Profile of Mood States (POMS) scores and State-Trait Anxiety Inventory scores in nonresponders (treatment-resistant patients; 30) and responders (38) with major depressive disorder (MDD), nonresponders (29) and responders (51) with panic disorder and 97 healthy controls. Results: The ghrelin concentration in nonresponders with MDD was higher than that of responders with MDD and normal controls. The ghrelin concentration in nonresponders with panic disorder was higher than that of normal controls. POMS vigor scores in patients with MDD and panic disorder were significantly decreased compared with those in healthy controls. Other POMS scores in patients with MDD and panic disorder were significantly increased compared with those of healthy controls. Trait and state anxiety of the State-Trait Anxiety Inventory in MDD and panic disorder patients were higher than those in healthy controls. Conclusions: These results indicate that decreased serum ghrelin levels might be associated with antidepressant treatment to confer the maximum therapeutic effect in patients with MDD and panic disorder.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Serum Ghrelin Levels and the Effects of Antidepressants in Major Depressive Disorder and Panic Disorder

Ishitobi

Kohno²,

Kanehisa³

et al. 2012

Neuropsychobiology

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show abstract

“…However, many others suggested no difference in ghrelin levels between depressive patients and healthy controls 21,22,23. Nevertheless, some studies found high serum ghrelin levels in patients with major depression 14,24. A few studies about the effect of treatment of depression on ghrelin levels reported a decrease with mirtazapine,25 an increase with maprotiline,26 and a decrease with ECT 14.…”

Section: Introductionmentioning

confidence: 99%

Serum Ghrelin and Leptin Levels in Patients with Depression and the Effects of Treatment

Özsoy

Beşirli

Abdülrezzak

et al. 2014

Psychiatry Investig

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ObjectiveGhrelin and leptin, appetite-regulating hormones, play a role in mood regulation. Current data about the relation between leptin/ghrelin and depression are still controversial. This study aimed to investigate serum leptin and ghrelin levels in patients with depression and the effects of treatment on these levels.MethodsSerum ghrelin and leptin levels were measured before and after treatment with antidepressant drugs and/or electroconvulsive therapy in 28 patients with depression and once in 21 healthy controls.ResultsSerum ghrelin levels of the patients were high in the pre-treatment. After the treatment, ghrelin levels were not different from those of the controls. We found no difference in serum levels of leptin between the patients and controls and no change with treatment. body mass index of the patients increased after the treatment especially in the drug-treated group.ConclusionThe present study found increased serum ghrelin levels in depressive patients and normalization with improving of depression but no alteration in leptin levels.

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“…Yapılan çalışmalarda ghrelinin nöroprotektiyonda önemli koruyucu etkisi olduğu bildirilmiştir (25). Literatürde depresif hastalarda düşük (26), yüksek (27) veya değişmeyen ghrelin seviyeleri bildirilmiştir (28). Depresyon hastalarında birbirinden farklı sonuçların bulunması depresyonda ghrelinin rolü ile ilgili bazı tartışmalara neden olmaktadır.…”

Section: Bulgularunclassified

Examining Nesfatin-1 and Ghrelin Hormone in Severity of Depression

Algül¹,

Erkeç²,

Kara³

et al. 2017

Van Med J

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The effects of electroconvulsive therapy on ghrelin, leptin and cholesterol levels in patients with mood disorders

Cited by 55 publications

References 23 publications

Serum Ghrelin Levels and the Effects of Antidepressants in Major Depressive Disorder and Panic Disorder

Serum Ghrelin Levels and the Effects of Antidepressants in Major Depressive Disorder and Panic Disorder

Serum Ghrelin and Leptin Levels in Patients with Depression and the Effects of Treatment

Examining Nesfatin-1 and Ghrelin Hormone in Severity of Depression

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