The effects of Elaeagnus angustifolia L. whole fruit on the sex hormone profile in menopausal women: A double-blind, randomized, placebo-controlled study

Emaminia, Farzaneh; Rezaei, Arezou; Badehnoosh, Bita; Ramezani, Rohollah; Shabani, Mahzad

doi:10.1016/j.jep.2019.112229

Cited by 4 publications

(26 citation statements)

References 36 publications

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“…Several studies have indicated that oestrogens up‐regulate mRNA expression of HDL receptor, and promote HDL‐C uptake in liver and peripheral tissues 47 . Although, about 28.3% increase of E2 after E. angustifolia consumption in postmenopausal women was not significant, 21 regarding the unchanged level of TC in the medicinal herb group, the significant decrease in HDL‐C level cannot be interpreted as the negative effect of E. angustifolia on lipid profile and the cardiovascular function in the present postmenopausal women. Particularly, the powder of whole E. angustifolia fruit reduced significantly the level of LDL‐C by 18.9% in between‐group analysis.…”

Section: Discussionmentioning

confidence: 97%

“…49 In our previous study, the FSH level increased insignificantly by 31.2% and reached to 53.73 IU/L after 10-week treatment with E. angustifolia. 21 It is noteworthy to…”

Section: Discussionmentioning

confidence: 99%

“…angustifolia fruits were the products of gardens in Damghan (Semnan province, Iran) in October 2017 which were prepared as previously described. 21 A voucher herbarium specimen of E. angustifolia (voucher number: Amirahmadi 1842 (DU000584)) was kept in herbarium of Damghan university. To prepare the placebo, corn starch (Bijan Pharmacy, Tehran) and isomalt from PuyaKabak Company Manufacturing and Trading (Batch No 1604112, Tehran, Iran) were provided with a 1:1 ratio.…”

Section: Experimental Groups and Treatmentsmentioning

confidence: 99%

“…20 In the previous study, we investigated the effects of E. angustifolia on sex hormone profile in postmenopausal women. 21 The aim of this study was to evaluate the effect of E. angustifolia whole fruit on cardiovascular function and lipid and glycaemic profiles in postmenopausal women.…”

Section: Introductionmentioning

confidence: 99%

“…The effectiveness of the E. angustifolia has been investigated in various cases, such as the function of cardiovascular system, the treatment of osteoporosis, skin and hair restoration, joint pain and knee and muscles, 19 anti‐tumour and anti‐inflammatory effects 20 . In the previous study, we investigated the effects of E. angustifolia on sex hormone profile in postmenopausal women 21 . The aim of this study was to evaluate the effect of E. angustifolia whole fruit on cardiovascular function and lipid and glycaemic profiles in postmenopausal women.…”

Section: Introductionmentioning

confidence: 99%

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The effects ofElaeagnus angustifoliaL. on lipid and glycaemic profiles and cardiovascular function in menopausal women: A double‐blind, randomized, placebo‐controlled study

Shabani

Rezaei

Badehnoosh³

et al. 2020

Int J Clin Pract

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Aims The reduced production of ovarian hormones is considered to be the cause of an increase in the incidence of heart disease in women after menopause. Phytoestrogens are found in various herbal sources and are considered as an alternative to hormone therapy because of structural similarity with oestrogen. Elaeagnus angustifolia L., known as Senjed in Persian, is used in Iranian traditional medicine with various medicinal properties, contains valuable compounds, including two types of phytoestrogens. The aim of the present study was to investigate the efficacy of E. angustifolia fruit on the cardiovascular function, lipid and glycaemic profiles in postmenopausal women. Methods In this double‐blind placebo‐controlled clinical trial, 58 postmenopausal women were randomly assigned into two experimental groups of medicinal herb (15 g/day of the whole E. angustifolia fruit powder) and placebo (15 g/day of isomalt + corn starch). Before the trial and after 10 weeks of the treatment, cardiovascular function (heart rate, blood pressure), serum glycaemic profile (fasting blood glucose; glycated haemoglobin, HbA1C), insulin and lipid profile (total cholesterol, TC; triglyceride, TG; LDL‐C and HDL‐C) were measured. Results Heart rate, and serum level of LDL‐C and HDL‐C significantly decreased after treatment with E. angustifolia. Changes in glycaemic profile were not clinically significant. In addition, some studied biochemical parameters significantly changed in the placebo group. Conclusions E. angustifolia was somewhat effective in improving cardiovascular function and lipid profile, as well as the overall health of postmenopausal women. However, the use of isomalt and corn starch in menopausal women needs further investigation.

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Section: Discussionmentioning

confidence: 97%

“…49 In our previous study, the FSH level increased insignificantly by 31.2% and reached to 53.73 IU/L after 10-week treatment with E. angustifolia. 21 It is noteworthy to…”

Section: Discussionmentioning

confidence: 99%

Section: Experimental Groups and Treatmentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The effects ofElaeagnus angustifoliaL. on lipid and glycaemic profiles and cardiovascular function in menopausal women: A double‐blind, randomized, placebo‐controlled study

Shabani

Rezaei

Badehnoosh³

et al. 2020

Int J Clin Pract

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Effect of PCL/nHAEA nanocomposite to osteo/odontogenic differentiation of dental pulp stem cells

et al. 2022

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Purpose The green synthesis of nanoparticles has recently opened up a new route in material production. The aim of this study was to evaluate the effect of nanohydroxyapatite (nHA) synthesized from Elaeagnus angustifolia (EA) extract in polycaprolactone (PCL) nanofibers (PCL/nHAEA) to odontogenic differentiation of dental pulp stem cells (DPSCs) and their potential applications for dentin tissue engineering. Methods Green synthesis of nHA via EA extract (nHAEA) was done by the sol–gel technique. Then electrospun nanocomposites containing of PCL blended with nHA (P/nHA) and nHAEA (P/nHAEA) were fabricated, and the characterization was evaluated via X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and the contact angle. The morphology of nanofibers and the cell adhesion capacity of DPSCs on nanofibers were evaluated using SEM. Cytocompatibility was assessed by MTT. Osteo/odontogenic differentiation ability of the nanocomposites were assessed using alkaline phosphatase (ALP) activity, alizarin red S (ARS) staining, and quantitative real-time polymerase chain reaction (qPCR) technique. Results Viability and adhesion capacity of DPSCs were higher on P/nHAEA nanofibers than PCL and P/nHA nanofibers. ARS assay, ALP activity, and qPCR analysis findings confirmed that the nHAEA blended nanofibrous scaffolds substantially increased osteo/odontogenic differentiation of DPSCs. Conclusion PCL/nHAEA nanocomposites had a noticeable effect on the odontogenic differentiation of DPSCs and may help to improve cell-based dentin regeneration therapies in the future.

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Production and characterization of newly developed alcohol-free topical liposome-gel transdermal drug delivery systems containing estradiol (E2)/ estriol (E3) for post-menopausal women

ASLAN,

AYTEKİN

2023

jrp

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The effects of Elaeagnus angustifolia L. whole fruit on the sex hormone profile in menopausal women: A double-blind, randomized, placebo-controlled study

Cited by 4 publications

References 36 publications

The effects ofElaeagnus angustifoliaL. on lipid and glycaemic profiles and cardiovascular function in menopausal women: A double‐blind, randomized, placebo‐controlled study

The effects ofElaeagnus angustifoliaL. on lipid and glycaemic profiles and cardiovascular function in menopausal women: A double‐blind, randomized, placebo‐controlled study

Effect of PCL/nHAEA nanocomposite to osteo/odontogenic differentiation of dental pulp stem cells

Production and characterization of newly developed alcohol-free topical liposome-gel transdermal drug delivery systems containing estradiol (E2)/ estriol (E3) for post-menopausal women

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