The effects of early experience on callosal development and functional lateralization in pigmental BALB/c mice

Bulman-Fleming, B.; Wainwright, P.E.; Collins, Robert L.

doi:10.1016/s0166-4328(05)80285-2

Cited by 31 publications

(18 citation statements)

References 55 publications

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“…Only one BALB/cWah1 mouse showed an abnormally small HC, whereas the HC was severely deficient in every 9XCA/Wah animal, including two in which there were almost no HC axons crossing the midline. There was a wide range of size of the CC in BALB/cWah1 mice, but this extreme size variation within BALB/cWah1 was not significantly related to fear conditioning (data not shown), which is consistent with the literature on behavioral sparing in CC agenesis (Schmidt et al, 1991;Bulman-Fleming et al, 1992;Wahlsten et al, 2001). As such, the focus of our analysis was on the difference between strains that arose from grossly different sizes of the HC.…”

Section: Commissural Anatomysupporting

confidence: 87%

“…This developmental variability within a genetically homogeneous strain provides a well controlled experiment of nature to assess the behavioral effects of an absent CC. Surprisingly, hereditary absence of the CC has little or no impact on a wide range of mouse behaviors (Schmidt et al, 1991;Bulman-Fleming et al, 1992;Wahlsten et al, 2001).…”

Section: Abstract: Hippocampal Commissure; Memory; Learning; Ltp; Fementioning

confidence: 99%

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Selective Modification of Short-Term Hippocampal Synaptic Plasticity and Impaired Memory Extinction in Mice with a Congenitally Reduced Hippocampal Commissure

Schimanski¹,

Wahłsten

Nguyen

2002

J. Neurosci.

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The hippocampus is critical for forming new long-term memories, but the contributions of the hippocampal commissure (HC) to memory function and hippocampal synaptic plasticity are unclear. To shed light on this issue, we characterized behavioral memory and hippocampal synaptic plasticity in two inbred mouse strains. BALB/cWah1 mice display a range of corpus callosal defects and an intact HC, whereas 9XCA/Wah mice exhibit a complete absence of corpus callosum and a greatly reduced HC. No differences between strains were found in long-term potentiation (LTP) within two synaptic pathways in hippocampal slices. However, paired-pulse facilitation was deficient in area CA1 of slices from 9XCA/Wah, and it was rescued by decreasing extracellular [Ca 2ϩ ], suggesting that presynaptic calcium dynamics may be altered in this strain. In addition, contextual fear extinction was impaired in 9XCA/Wah mice, but performance on cued fear extinction and on 24 hr memory tests for cued and contextual fear conditioning were not significantly different between strains. Thus, an intact HC is critical for normal extinction of contextual fear. Intact interhemispheric connectivity is not required for acquisition or expression of cued and contextual fear conditioning. LTP was normal in slices from mice that lacked an intact HC, and this was correlated with normal performance on fear conditioning tests. In contrast, impaired short-term synaptic plasticity was correlated with defective contextual memory extinction in mice lacking an intact HC. Thus, the HC in mice is vital for particular aspects of memory function and for short-term synaptic modification in specific hippocampal circuits. Key words: hippocampal commissure; memory; learning; LTP; fear conditioning; extinction; agenesis; mouse strains; synaptic plasticityThe classic case study of H.M., a patient with surgical transection of the medial temporal lobes, demonstrated that the hippocampus is critical for the formation of new declarative memories (Scoville and Milner, 1957). Studies of human commissurotomy patients indicate that the main interhemispheric communication pathway between hippocampi, the hippocampal commissure (HC), is important for normal memory function. Indeed, patients with a transected HC show greater recognition memory deficits than those with an intact HC (Phelps et al., 1991). Patients with transection of both the corpus callosum (CC) and the HC also showed poor memory performance (Zaidel and Sperry, 1974). These findings indicate that an intact CC and HC are required for normal memory function.In two common inbred mouse strains, BALB/c and 129, agenesis of the CC occurs in Ͻ50% of these mice, whereas the remainder appear to have normal forebrain commissures (see Fig.

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Section: Commissural Anatomysupporting

confidence: 87%

Section: Abstract: Hippocampal Commissure; Memory; Learning; Ltp; Fementioning

confidence: 99%

Selective Modification of Short-Term Hippocampal Synaptic Plasticity and Impaired Memory Extinction in Mice with a Congenitally Reduced Hippocampal Commissure

Schimanski¹,

Wahłsten

Nguyen

2002

J. Neurosci.

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“…Typically, fewer than half the mice in inbred strains such as BALB/c and 129 have no CC [35], a condition termed incomplete penetrance, and this within-strain non-genetic variation provides an excellent test of CC function. No relation of CC size in these strains is apparent with paw preference scores [7,13,27], the speed of running on a wheel [3], or performance on several common behavioral tasks [17,34], although some indication exists that mouse strains with a high frequency of absent CC also show deficits on a notched balance beam [21].…”

Section: Introductionmentioning

confidence: 99%

Wheel running behavior is impaired by both surgical section and genetic absence of the mouse corpus callosum

Schalomon

Wahłsten

2002

Brain Research Bulletin

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These results are not totally conclusive because the strains in question also show a number of behavioral peculiarities that are unrelated to the effects of an absent CC [2,18,20,26], and it remains possible that effects of absent CC may depend on the strain background, just as CC absence does [22]. The present paper addresses this limitation by utilizing several recombinant inbred lines created from the 129 and BALB/c strains, so that genes responsible for absence of the CC would not likely be spuriously correlated with genes relevant for abnormal behavior.The literature on humans lacking the CC points to mild, language-related deficits in intelligence and rhyming [10,24], and it suggests that deficits are most likely to appear on motor tasks, in which pressure exists to perform at high speed [14,23]. In this paper, we report that CC-related deficits in high-speed wheel running indeed appear when the task is rendered more difficult by removing several rungs from the wheel.The interpretation of behavioral test results from acallosal mice is challenging because usually no compelling reason exists to believe that the behaviors in question rely heavily on interhemispheric communication. It is also possible that as with human CC agenesis [9,11,19,29], developmental plasticity creates or pre-serves alternative

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“…1 and were observed reaching for flakes of rolled oat cereal until 50 reaches were recorded for each animal. (Details of the apparatus can be found in [14].) The internal diameter of the food tube for this session was 6.5 mm (narrow), the same as that used by Collins [8].…”

Section: Paw Preference Testing Sessionsmentioning

confidence: 99%

“…Biddle's group [13] has also recently reported strain differences in RPE scores and our own independent reanalysis of the Signore et al data supports both a leftward population bias and strain differences in RPE 2 . The Collins test has been a very popular method for determining paw preference in mice; several groups of workers have employed this procedure to investigate the influences of various factors on mouse paw preference [14][15][16][17][18][19]11]. As a result of this popularity and of the recent results mentioned above, which suggest that the mouse model for human handedness may be even more relevant than was previously believed, it would seem important to investigate the parameters of the paw preference testing protocol.…”

Section: Introductionmentioning

confidence: 99%

Mouse paw preference: effects of variations in testing protocol

Bulman-Fleming

Bryden

Rogers

1997

Behavioural Brain Research

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Two experiments using two inbred strains of mice were conducted to study mouse paw preference. In the first study, 250 (50× 5) paw reaches from each of 12 male and 12 female C57BL/6J mice were observed over an 8-week period using the Collins paw preference apparatus to investigate questions relating to the independence of reaches, the size of the tube into which the animals reach for flakes of food, and practise effects. Animals appeared to be much more highly lateralized when two independent reaches per day for 25 days (I protocol) were observed than when 50 reaches were observed in a single session (S protocol). Paradoxically, however, we found no evidence for the lack of independence of reaches when we examined the sequences of reaches performed by animals under the S protocol conditions. With practise, animals became slightly more lateralized, but there were no effects of sex, and approximately equal numbers of mice were left-pawed as were right-pawed. The size of the tube had no effect. The second study used 30 BALB mice, each of which was tested with both the I and S protocols, with order of testing counterbalanced. There was a significant protocol×order interaction such that those doing S first were more highly lateralized on the I task, but those doing I first were highly lateralized on both tasks. © 1997 Elsevier Science Ireland B.V.

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The effects of early experience on callosal development and functional lateralization in pigmental BALB/c mice

Cited by 31 publications

References 55 publications

Selective Modification of Short-Term Hippocampal Synaptic Plasticity and Impaired Memory Extinction in Mice with a Congenitally Reduced Hippocampal Commissure

Selective Modification of Short-Term Hippocampal Synaptic Plasticity and Impaired Memory Extinction in Mice with a Congenitally Reduced Hippocampal Commissure

Wheel running behavior is impaired by both surgical section and genetic absence of the mouse corpus callosum

Mouse paw preference: effects of variations in testing protocol

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