The effects of dynamic hyperinflation on CT emphysema measurements in patients with COPD

Alves, Giordano Rafael Tronco; Marchiori, Edson; Irion, Klaus; Teixeira, Paulo José Zimermann; Berton, Danilo Cortozi; Rubin, Adalberto Sperb; Hochhegger, Bruno

doi:10.1016/j.ejrad.2014.08.014

Cited by 5 publications

(3 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Except for lung volume tests, recent evidence has supported using radiography methods, such as computed tomography, to evaluate lung hyperinflation severity in patients with COPD. 21 – 23 These assessments are intuitive and accurate, but the radiographic method is not a repeatable or acceptable choice due to its high cost and level of radiation exposure. Considering the lack of advanced equipment and complex technology in primary care settings, especially in developing countries, the present study provided a simple method to detect lung hyperinflation, in which the cutoff values of ΔFVC and its derivatives exhibited relatively high sensitivity and specificity, especially for GOLD stage I patients.…”

Section: Discussionmentioning

confidence: 99%

Early COPD patients with lung hyperinflation associated with poorer lung function but better bronchodilator responsiveness

Chen¹,

Jian²,

Gao³

et al. 2016

COPD

View full text Add to dashboard Cite

BackgroundIt is unknown whether aggressive medication strategies should be used for early COPD with or without lung hyperinflation. We aimed to explore the characteristics and bronchodilator responsiveness of early COPD patients (stages I and II) with/without lung hyperinflation.MethodsFour hundred and six patients with COPD who performed both lung volume and bronchodilation tests were retrospectively analyzed. Residual volume to total lung capacity >120% of predicted values indicated lung hyperinflation. The characteristics and bronchodilator responsiveness were compared between the patients with and without lung hyperinflation across all stages of COPD.ResultsThe percentages of patients with lung hyperinflation were 72.7% in the entire cohort, 19.4% in stage I, 68.5% in stage II, 95.3% in stage III, and 100.0% in stage IV. The patients with lung hyperinflation exhibited poorer lung function but better bronchodilator responsiveness of both forced expiratory volume in 1 second and forced vital capacity than those without lung hyperinflation during early COPD (t=2.21–5.70, P=0.000–0.029), especially in stage I, while age, body mass index, smoking status, smoking history, and disease duration were similar between the two subgroups in the same stages. From stages I to IV of subgroups with lung hyperinflation, stage I patients had the best bronchodilator responsiveness. Use of bronchodilator responsiveness of forced vital capacity to detect the presence of lung hyperinflation in COPD patients showed relatively high sensitivities (69.5%–75.3%) and specificities (70.3%–75.7%).ConclusionWe demonstrated the novel finding that early COPD patients with lung hyperinflation are associated with poorer lung function but better bronchodilator responsiveness and established a simple method for detecting lung hyperinflation.

show abstract

Section: Discussionmentioning

confidence: 99%

Early COPD patients with lung hyperinflation associated with poorer lung function but better bronchodilator responsiveness

Chen¹,

Jian²,

Gao³

et al. 2016

COPD

View full text Add to dashboard Cite

show abstract

“…This study indicated the possibility to quantify hyperinflation and visualization in COPD patients. Several studies have reported the quantification of hyperinflation using chest CT volumetry [15,16]. However, supine positioning examination with the ignorance of gravity effect cannot perfectly reflect the physiological condition of COPD patients.…”

Section: Discussionmentioning

confidence: 99%

Projected lung area using dynamic X-ray (DXR) with a flat-panel detector system and automated tracking in patients with chronic obstructive pulmonary disease (COPD)

Hino¹,

Tsunomori²,

Fukumoto³

et al. 2022

European Journal of Radiology

View full text Add to dashboard Cite

“…The method of evaluating DLH using computed tomography (CT) is similar to the method of measuring hyperventilation using spirometry [32]. Evaluation of dynamic pulmonary hyperinflation with CT showed significant increases in emphysema volume and emphysema index.…”

Section: Computed Tomographymentioning

confidence: 99%

Detection of Dynamic Lung Hyperinflation

Kominami

2022

IJOPRS

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease (COPD) is the general term for what has traditionally been referred to as chronic bronchitis and emphysema. COPD is commonly caused by inhaling toxic substances, harmful gases, and air pollution. COPD is an irreversible pathology that causes airflow obstruction and ventilation impairment. Until now, there is no complete treatment for COPD, and the main focus is on symptomatic treatment to improve symptoms and delay pathological progression. Airflow obstruction in COPD is caused by a decrease in pulmonary elastic contractile pressure due to peripheral airway involvement and emphysematous lesions, resulting in collapsed airways and the trapping of air in the lungs during forced expiration (referred to as unk or unk air trapping). Air trapping caused by collapsed peripheral airways strengthens with exertion or exercise, causing further lung hyperinflation. In COPD, dynamic lung hyperinflation (DLH) is one of the most significant determinants of short of breath (SOB) on exertion and exercise capacity. It is also an essential determinant in patients with significant lung hyperinflation and emphysema-dominant COPD. Measurement of DLH requires expensive equipment and instruments and is rarely evaluated in routine clinical practice. This review provides a summary of methods for measuring DLH, reaffirms how DLH and its therapeutic effects can be evaluated in routine practice, and outlines new methods that are being proposed.

show abstract

The effects of dynamic hyperinflation on CT emphysema measurements in patients with COPD

Cited by 5 publications

References 29 publications

Early COPD patients with lung hyperinflation associated with poorer lung function but better bronchodilator responsiveness

Early COPD patients with lung hyperinflation associated with poorer lung function but better bronchodilator responsiveness

Projected lung area using dynamic X-ray (DXR) with a flat-panel detector system and automated tracking in patients with chronic obstructive pulmonary disease (COPD)

Detection of Dynamic Lung Hyperinflation

Contact Info

Product

Resources

About