The Effects of Dynamic Compressive Loading on Biodegradable Implants of 50–50% Polylactic Acid–Polyglycolic Acid

Thompson, Douglas E.; Agrawal, C. Mauli; Athanasiou, Kyriacos A.

doi:10.1089/ten.1996.2.61

Cited by 53 publications

(26 citation statements)

References 30 publications

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“…When there is insufficient flow to drain the acidic degradation products from the matrix, the rate of degradation is thus enhanced [1, 3, 45]. Likewise, PLA devices degrade faster when they are less porous [2], less permeable [81], have a bulkier de- sign [39], and function under static loading conditions [1,97]. Due to these many factors, it is difficult to predict degradation kinetics of a device in a particular application, even if an identical, well characterized, material is used.…”

Section: Degradationmentioning

confidence: 99%

Bioresorbable polymers: heading for a new generation of spinal cages

2005

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Section: Degradationmentioning

confidence: 99%

Bioresorbable polymers: heading for a new generation of spinal cages

2005

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“…Results also demonstrated that cyclic compressive loading significantly slowed the decrease of molecular chain size during the first week, significantly increased protein release for the first 2-3 weeks, and significantly stiffened the implant for the first 3 weeks. In addition, this study showed that dynamic loading and the environment in which an implant was placed affect its biodegradation [27]. By providing a greater understanding of the degradation properties of PLGA, these studies provided a foundation for future in vivo studies.…”

Section: Biodegradable Scaffoldsmentioning

confidence: 83%

Harnessing Biomechanics to Develop Cartilage Regeneration Strategies

Athanasiou

Responte²,

Brown

et al. 2015

Journal of Biomechanical Engineering

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laboratory over the past 25 years. The prevalence and severity of degeneration of articular cartilage, a tissue whose main function is largely biomechanical, have motivated the development of cartilage tissue engineering approaches informed by biomechanics. This article provides a review of important steps toward regeneration of articular cartilage with suitable biomechanical properties. As a first step, biomechanical and biochemical characterization studies at the tissue level were used to provide design criteria for engineering neotissues. Extending this work to the single cell and subcellular levels has helped to develop biochemical and mechanical stimuli for tissue engineering studies. This strong mechanobiological foundation guided studies on regenerating hyaline articular cartilage, the knee meniscus, and temporomandibular joint (TMJ) fibrocartilage. Initial tissue engineering efforts centered on developing biodegradable scaffolds for cartilage regeneration. After many years of studying scaffold-based cartilage engineering, scaffoldless approaches were developed to address deficiencies of scaffold-based systems, resulting in the self-assembling process. This process was further improved by employing exogenous stimuli, such as hydrostatic pressure, growth factors, and matrix-modifying and catabolic agents, both singly and in synergistic combination to enhance neocartilage functional properties. Due to the high cell needs for tissue engineering and the limited supply of native articular chondrocytes, costochondral cells are emerging as a suitable cell source. Looking forward, additional cell sources are investigated to render these technologies more translatable. For example, dermis isolated adult stem (DIAS) cells show potential as a source of chondrogenic cells. The challenging problem of enhanced integration of engineered cartilage with native cartilage is approached with both familiar and novel methods, such as lysyl oxidase (LOX). These diverse tissue engineering strategies all aim to build upon thorough biomechanical characterizations to produce functional neotissue that ultimately will help combat the pressing problem of cartilage degeneration. As our prior research is reviewed, we look to establish new pathways to comprehensively and effectively address the complex problems of musculoskeletal cartilage regeneration.

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“…It has been well reported that the mechanical stimuli altered the physiological behaviors of cells [1,2] and mediated the scaffold degradation [3,4].…”

Section: Introductionmentioning

confidence: 99%

A Finite Element Model Revealing Stress Distribution on Tissue Engineering Scaffold in Perfused Bioreactor

2013

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Abstract-It has been well reported that the mechanical stimuli altered the physiological behaviors of cells and mediated the tissue engineering scaffold degradation. However, the accurate local stress was still unknown inside the scaffold since the microstructure is too complicated to study using traditional methods. In this study, we developed a simplified finite element model to evaluate the stress range and distribution on the porous scaffold in perfused bioreactor. Due to our results, the stress on scaffold decreased from inlet to outlet under perfusing while increased under drawing; the stress distribution range on scaffold was closely correlated with the flow rate and scaffold permeability. In conclusion, our study suggests that lower flow rate and higher scaffold permeability generated more uniform mechanical environment for cell growth and scaffold degradation.

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The Effects of Dynamic Compressive Loading on Biodegradable Implants of 50–50% Polylactic Acid–Polyglycolic Acid

Cited by 53 publications

References 30 publications

Bioresorbable polymers: heading for a new generation of spinal cages

Bioresorbable polymers: heading for a new generation of spinal cages

Harnessing Biomechanics to Develop Cartilage Regeneration Strategies

A Finite Element Model Revealing Stress Distribution on Tissue Engineering Scaffold in Perfused Bioreactor

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