The effects of dopamine and adrenaline infusions on acid-base balance and systemic haemodynamics in severe infection

Day, Nicholas P. J.; Phu, Nguyen Hoan; Bethell, Delia; Th, Nguyên; Chau, Tran T.H.; Hien, Tran Tinh; White, Nicholas J.

doi:10.1016/s0140-6736(96)09096-4

Cited by 206 publications

(94 citation statements)

References 19 publications

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“…Rationale The physiologic effects of vasopressors and combined inotrope/vasopressor selection in septic shock are outlined in an extensive number of literature reviews [252][253][254][255][256][257][258][259][260][261]. Norepinephrine increases MAP due to its vasoconstrictive effects, with little change in heart rate and less increase in stroke volume compared with dopamine.…”

Section: G Vasoactive Medicationsmentioning

confidence: 99%

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

et al. 2017

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Objective: To provide an update to "Surviving Sepsis Campaign Guidelines for Management of Sepsis and Septic Shock: 2012". Design:A consensus committee of 55 international experts representing 25 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict-of-interest (COI) policy was developed at the onset of the process and enforced throughout. A stand-alone meeting was held for all panel members in December 2015. Teleconferences and electronic-based discussion among subgroups and among the entire committee served as an integral part of the development. Methods:The panel consisted of five sections: hemodynamics, infection, adjunctive therapies, metabolic, and ventilation. Population, intervention, comparison, and outcomes (PICO) questions were reviewed and updated as needed, and evidence profiles were generated. Each subgroup generated a list of questions, searched for best available evidence, and then followed the principles of the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system to assess the quality of evidence from high to very low, and to formulate recommendations as strong or weak, or best practice statement when applicable.

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Section: G Vasoactive Medicationsmentioning

confidence: 99%

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

et al. 2017

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“…The patients who were diagnosed with hyperlactatemic metabolic diseases, died within first 2 hours after admission, transfered from another PICU or NICU were excluded. The patients who recieved adrenalin [12], metformin [13], nucleoside analogues [14], highvolume hemofiltration (HVHF) with lactatebuffered replacement fluids [15] were also excluded as they are known to affect lactate levels. The patients with inadequate hospital records were also excluded.…”

Section: Study Groupmentioning

confidence: 99%

The reasons of hyperlactatemia on admission and relationship of the lactate levels with clinical outcomes in pediatric intensive care unit

Bağ¹,

Karaarslan²,

İşgüder³

et al. 2017

Pau Med J

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Purpose:Hyperlactatemia has been reported to predict mortality and morbidity in critically ill patients. The aim of this study is to define the reasons of hyperlactatemia on admission in critical pediatric patients, to describe a cut off value to predict mortality and to evaluate the outcomes of admission hyperlactatemia in pediatric intensive care unit. Materials and methods: Hospital records of 202 pediatric patients who had admitted to pediatric intensive care unit (Male/Female: 101/101; median age: 3 years [IQR: 9.2] ) were evaluated retrospectively, for the study. Age, gender, admission diagnosis, arterial blood gas analysis, length of stay, presence of in-hospital mortality were recorded in the study group. Hyperlactatemia was defined according to L-lactate levels defined by age. The patients with and without hyperlactatemia were compared for mortality and clinical outcomes. Results:The frequency of admission hyperlactatemia was 64.3% (n: 130). The patients with dehydration due to acute gastroenteritis, acute respiratory insufficiency and acaute cardiac insufficiency had significantly higher lactate levels compared with children with other diagnosis. Admission hyperlactatemia was not found to have a cut-off value to predict mortality by ROC analysis (Area under curve: 0.57). Moreover, hyperlactatemia was not found to effect either mortality rate or outcome in the study group. Conclusion:The results of this study indicate that admission hyperlactatemia may not be used as a predictor of either death or poor clinical outcome in pediatric intensive care units. Further there is a lack of cut off value for lactate in literature to predict outcomes in different pediatric ages. Pam Med J 2017;(1):1-6Key words: Hyperlactatemia, admission, childhood, PICU. ÖzetAmaç: Laktat yüksekliğinin kritik hasta izleminde mortalite ve morbiditeyi belirleyici olduğunu gösteren çalişmalar mevcuttur. Bu araştirmanin amaci, kritik hastaliği olan çocuklarda laktat yüksekliğinin nedenlerini belirlemek, mortaliteyi belirleyen bir eşik değer olup olmadiğini saptamak ve çocuk yoğun bakim ünitesinde laktat yüksekliğinin klinik sonuçlarini değerlendirmektir. Gereç ve yöntem: Çocuk yoğun bakim ünitesine başvuran toplam 202 olgunun (Erkek/Kiz: 101/101; median yaş: 3 [IQR: 9.2]) dosya kayitlari geriye dönük olarak incelendi. Hastalarin yaşi, cinsiyeti, başvuru tanisi, arteriyel kan gazi sonuçlari, hastanede kalma süresi, ve ölüm varliği kaydedildi. Laktat yüksekliği, yaş gruplarina göre düzeylerine göre tanimlandi. Başvuruda laktat yüksekliği olan ve olmayan olgular, ölüm oranlari ve klinik sonuçlar açisindan karşilaştirildi. Bulgular: Başvuruda saptanan hiperlaktatemi sikliği %64.3 (n: 130) idi. Akut gastroenterite bağli dehidratasyon, akut solunumsal yetmezlik ve akut kalp yetmezliği olanlarda laktat düzeyleri diğer tanilarla karşilaştirildiğinda anlamli olarak daha yüksek bulundu. ROC analizi ile mortaliteyi belirleyecek herhangi bir eşik değer saptanmadi (eğri alti alan: 0.57). Ayrica, hiperlaktateminin mortalite ve klinik sonuçla...

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“…Since malaria can be associated with profound acidosis, if inotropic support is instituted, it may be preferable to avoid or limit the dose of epinephrine as this agent can increase lactate production and exacerbate acidosis. 45 Dopamine, dobutamine, or norepinephrine have been used in the treatment of severe malaria and are suitable alternatives. Fluid balance may be particularly difficult to manage during surgery if there is acute blood loss.…”

Section: Cardiacmentioning

confidence: 99%

Perioperative considerations of the patient with malaria

Soltanifar

Carvalho

Sultan

2014

Can J Anesth/J Can Anesth

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Purpose Malaria is a life-threatening infectious disease caused by the Plasmodium parasite. Increased global travel has resulted in an escalation in the number of imported cases seen in developed countries. Patients with malaria may present for surgery in both endemic and nonendemic countries. This article reviews the perioperative considerations when managing patients with malaria. Source A literature review of anesthesia, perioperative care, and malaria-related articles was performed using the MEDLINE Ò , EMBASE TM , and Web of Science databases to identify relevant articles published in English during . Of the 303 articles matching the search criteria, 265 were excluded based on title and abstract. Eleven of the remaining 38 articles were relevant to anesthesia/perioperative care, and 27 articles were identified as having direct relevance to critical care medicine. Principal findings The majority of imported malaria cases are caused by the falciparum species, which is associated with the greatest degree of morbidity and mortality. Various organ systems may be impacted as a consequence of changes in the structure and function of parasitized erythrocytes. Preoperative assessment should focus on establishing the species of malaria, the severity of disease, assessing the degree of end-organ impairment, and initiating treatment of malaria prior to surgery. Intravenous artesunate is the treatment of choice for severe falciparum malaria. Quinine is a second-line agent but has a narrow therapeutic index and particularly hazardous side effects. Intraoperatively, attention should focus on fluid management, dynamics of cerebral blood flow, and avoidance of hypoglycemia. Postoperative care of severe cases should ideally take place in a critical care unit as there may be ongoing requirements for multi-organ support, including renal replacement therapy, ventilation, and/or inotropic support. The safety of neuraxial anesthesia has not been well studied in the setting of malaria. Conclusions Malaria remains one of the most devastating infectious diseases worldwide. Multiple organ systems can be impacted as a consequence of changes in structure and function of parasitized erythrocytes. Safe perioperative management requires a sound knowledge of all these potential system effects. RésuméObjectif Le paludisme est une maladie infectieuse possiblement fatale due au parasite Plasmodium. La multiplication des voyages à travers le monde a entraîné un accroissement du nombre de cas importés observés dans les pays développés. Les patients atteints de paludisme peuvent nécessiter une chirurgie, aussi bien dans les pays où la maladie est endémique que dans les autres. Cet article passe en revue les considérations périopératoires lors de la prise en charge de patients atteints de paludisme. Source Une revue de la littérature à la recherche d'articles d'anesthésie, de soins périopératoires et en Author contributions Daniel Soltanifar, Brendan Carvalho, and Pervez Sultan all made substantial contributions to the literature review, ...

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The effects of dopamine and adrenaline infusions on acid-base balance and systemic haemodynamics in severe infection

Cited by 206 publications

References 19 publications

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

The reasons of hyperlactatemia on admission and relationship of the lactate levels with clinical outcomes in pediatric intensive care unit

Perioperative considerations of the patient with malaria

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