The Effects of Direct Factor Xa Inhibitor (Rivaroxaban) on the Human Osteoblastic Cell Line SaOS2

Comparison of the effects of heparin and the direct factor Xa inhibitor, rivaroxaban, on bone microstructure and metabolism in adult rats

“…Preclinical studies have come to differing conclusions. Klüter et al (16) (17). Rivaroxaban inhibited the stimulation of cell proliferation, energy metabolism, alkaline phosphatase specific activity and mRNA modulation by a variety of hormones, i.e.…”

Oral Anticoagulant Drugs and the Risk of Osteoporosis: New Anticoagulants Better than Old?

“…Gigi et al evaluated the factor Xa inhibitor rivaroxaban using an in vitro cell culture model from the human female osteoblastic cell line SaOS2. 31 Cells at subconfluence were treated for 24 hours with different concentrations of rivaroxaban and analyzed for DNA synthesis and creatine kinaseand alkaline phosphatase-specific activities. Treatment was continued for 21 days for analyzing mineralization.…”

“…Osteoblastic mineralization was unaffected, indicating that rivaroxaban inhibits the first stage of bone formation but does not exert effects in later stages (bone mineralization), thus producing a transient inhibition of bone formation. 31 The same authors investigated the effects of rivaroxaban on SaOS2 response to osteoblast-modulating hormones. 32 At subconfluence cells were treated with estradiol-17β, phytoestrogens, estrogen receptor α (ERα) and β (ERβ) agonists, parathyroid hormone, and several vitamin D metabolites and analogs, in the presence or in the absence of rivaroxaban for 24 hours.…”

The effect of a new oral anticoagulant (Rivaroxaban) on implants pull-out strength. An experimental study in rats

“…Recent work from Israel 11 showed no delay in bone healing as well as no affection of cell mineralization after the administration of high doses of Rivaroxaban. This phenomenon can be explained by the effect of the drug being transient or by an adaptation of the cells to the inhibiting effect and compensation by some other mechanism 12,25 . It seems that the role of hematoma (post-traumatic or post-surgical) is essential in fracture healing as well as in osseointegration.…”