The effects of dihydroergocryptine on the neurological and enzyme disorders induced by cerebral ischaemia in rats

Cahn, R.; Borzeix, M. G.; Legeai, J.

doi:10.1016/0300-9572(89)90111-1

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…It has been reported that Na + –K + ATPase consumes 40%–50% of the ATP generated in the brain [ 29 ] and the decrease in this enzyme activity is considered to reflect the consequences of the neurocyte energetic metabolism alterations caused by cerebral ischemia. [ 30 ] Evidence suggested that Na + –K + ATPase activity, which was very sensitive to hypoxia would be reduced or insufficient to maintain ionic balances during and immediately after episodes of ischemia and Na + –K + ATPase inhibition persisted during reoxygenation. [ 24 , 31 , 32 ] The excessive retention of sodium results in osmotic swelling and possible cellular lysis and causes a failure of sodium–calcium exchange system that is responsible for a build-up of intracellular calcium.…”

Section: Resultsmentioning

confidence: 99%

Protective effects of traditional Chinese medicine formula NaoShuanTong capsule on haemorheology and cerebral energy metabolism disorders in rats with blood stasis

Liu

Peng

Liang

et al. 2014

Biotechnology & Biotechnological Equipment

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NaoShuanTong capsule (NSTC), an oral traditional Chinese medicine formula, is composed of Pollen Typhae, Radix Paeoniae Rubra, Rhizoma Gastrodiae, Radix Rhapontici and Radix Curcumae. It has been widely used to treat ischemic stroke in clinic for many years in China. In addition to neuronal apoptosis, haemorheology and cerebral energy metabolism disorders also play an important role in the pathogenesis and development of ischemic stroke. The present study was designed to evaluate the in vivo protective effects of NSTC on haemorheology and cerebral energy metabolism disorders in rats with blood stasis. Sixty specific pathogen-free sprague-dawley rats, male only, were randomly divided into six groups (control group, model group, aspirin (100 mg/kg/d) group, NSTC low-dose (400 mg/kg/d) group, NSTC intermediate-dose (800 mg/kg/d) group, NSTC high-dose (1600 mg/kg/d) group) with 10 animals in each. The rats except those in the control group were placed in ice-cold water (0–4 °C) for 5 min during the time interval (4 h) of two adrenaline hydrochloride injections (0.8 mg/kg) to induce blood stasis. After treatment, whole blood viscosity at three shear rates, plasma viscosity and erythrocyte sedimentation rate significantly decreased in NSTC intermediate- and high-dose groups; erythrocyte aggregation index and red corpuscle electrophoresis index significantly decreased in all the three dose NSTC groups. Moreover, treatment with high-dose NSTC could significantly improve Na+–K+ adenosine triphosphatase (ATPase) and Ca2+ ATPase activity, as well as lower lactic acid level in brain tissues. These results demonstrated the protective effects of NSTC on haemorheology and cerebral energy metabolism disorders, which may provide scientific information for the further understanding of mechanism(s) of NSTC as a clinical treatment for ischemic stroke. Furthermore, the protective effects of activating blood circulation as observed in this study might create valuable insight for the utilisation of NSTC to be a feasible alternative therapeutic agent for patients with blood stasis.

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Section: Resultsmentioning

confidence: 99%

Protective effects of traditional Chinese medicine formula NaoShuanTong capsule on haemorheology and cerebral energy metabolism disorders in rats with blood stasis

Liu

Peng

Liang

et al. 2014

Biotechnology & Biotechnological Equipment

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“…Препарат Вазобрал также используется при снижении умственной активности, нарушениях внимания и памяти вследствие хронической цереброваскулярной недостаточности [10]. В экспериментальном исследовании Cahn et al установили, что введение подопытным животным меченной радиоактивным изотопом глюкозы на фоне приема препарата приводит к значительному усилению мозгового кровотока в обоих полушариях и увеличению захвата глюкозы нейронами мозга [11]. В клиническом исследовании M. Le Poncin et al.…”

Section: одной из составляющих патогенеза повреждения мозговой ткани unclassified

Chronic cerebrovascular diseases: pathogenetic heterogeneity and therapeutic strategies

Костенко

Eneeva

2018

Med. sov.

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The article presents a modern view of the pathogenic mechanisms of cerebrovascular diseases was Observed that currently available data indicate the existence of different variants of ischemic lesions of the brain and their clinical manifestations. Based on the available data and the results of our own studies, it is concluded that therapeutic strategies in patients with CVD should take into account the variety of clinical manifestations, the existence of various options for ischemic lesions of the brain substance, especially the course of the disease, heterogeneity of pathogenetic mechanisms and risk factors, as well as multi-morbidity of patients. Discusses the use of the drug Vazobral in CVD.

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“…Подтверждено и его позитивное влияние на агрегацион-ную способность эритроцитов и тромбоцитов. При при-менении Вазобрала интенсивность захвата глюкозы уве-личивается на 40-50%, а уровень мозгового кровообра-щения, по сравнению с контролем, повышается в среднем на 64% [62]. В исследовании, проведенном Батышевой Т.Т.…”

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Issues in rehabilitation of patients after stroke in the out-patient setting

Пизова¹

2018

Med. sov.

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The effects of dihydroergocryptine on the neurological and enzyme disorders induced by cerebral ischaemia in rats

Cited by 3 publications

References 17 publications

Protective effects of traditional Chinese medicine formula NaoShuanTong capsule on haemorheology and cerebral energy metabolism disorders in rats with blood stasis

Protective effects of traditional Chinese medicine formula NaoShuanTong capsule on haemorheology and cerebral energy metabolism disorders in rats with blood stasis

Chronic cerebrovascular diseases: pathogenetic heterogeneity and therapeutic strategies

Issues in rehabilitation of patients after stroke in the out-patient setting

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