The effects of diflunisal on bleeding time and platelet aggregation in a multidose study

Chapman, P. J.; Macleod, A. W. Gordon

doi:10.1016/s0901-5027(87)80083-8

Cited by 8 publications

(3 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Evaluation in the oral surgery model demonstrates that diflunisal has greater peak analgesia than aspirin 650 as well as a duration of effect up to 12 hrs, making a twice-daily dosing regimen possible (Forbes et al, 1982). In another oral surgery study (N = 15), mean bleeding time was increased by 53% for the group, but in no patient did the increase exceed the upper limit of normal bleeding time (Chapman and Macleod, 1987). There was no increased tendency for intra-operative or post-operative bleeding.…”

Section: (I) Diflunisalmentioning

confidence: 99%

Therapeutic Uses of Non-Steroidal Anti-Inflammatory Drugs in Dentistry

Dionne

Berthold

2001

Critical Reviews in Oral Biology & Medicine

View full text Add to dashboard Cite

The non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used classes of drugs for the management of acute and chronic pain in dentistry. Their therapeutic efficacy and toxicity are well-documented and provide evidence that NSAIDs generally provide an acceptable therapeutic ratio of pain relief with fewer adverse effects than the opioid-mild analgesic combination drugs that they have largely replaced for most dental applications. The great many studies done with the oral surgery model of acute pain indicate that a single dose of an NSAID is more effective than combinations of aspirin or acetaminophen plus an opioid, with fewer side-effects, thus making it preferable for ambulatory patients. The combination of an NSAID with an opioid generally results in marginal analgesic activity but with an increased incidence of side-effects, which limits its use to patients in whom the NSAID alone results in inadequate analgesia. The selective COX-2 inhibitors hold promise for clinical efficacy with less toxicity from chronic administration and may prove advantageous for the relief of chronic orofacial pain. The use of repeated doses of NSAIDs for chronic orofacial pain should be re-evaluated in light of a lack of documented efficacy and the potential for serious gastrointestinal and renal toxicity with repeated dosing.

show abstract

Section: (I) Diflunisalmentioning

confidence: 99%

Therapeutic Uses of Non-Steroidal Anti-Inflammatory Drugs in Dentistry

Dionne

Berthold

2001

Critical Reviews in Oral Biology & Medicine

View full text Add to dashboard Cite

show abstract

“…Diflunisal provides a small but clinically unhelpful antipyretic effect, and a mild uricosuria. In some individuals platelet function and bleeding time may be affected, but during twice daily dosing with 500 mg for 5 days, no individual’s bleeding time exceeded the upper limit of normal (Chapman 1987). The effect of diflunisal on platelets is reversible, unlike that of aspirin.…”

Section: Introductionmentioning

confidence: 99%

Single dose oral diflunisal for acute postoperative pain in adults

Wasey

Derry

Moore

et al. 2010

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

show abstract

“…Prinzipiell sind ASS und NSAID (unmittelbar präoperativ gegeben) wirkungsähnlich, obwohl hinsichtlich der Genese, insbesondere der Dauer der Thrombozytenhemmung und ihrer Reversibilität, Unterschiede bestehen [5].…”

Section: Introductionunclassified

The influence of treatment with aspirin in the preoperative management of kidney transplantation?

Werner

Klemm

Wunderlich

et al. 1998

Urologe

View full text Add to dashboard Cite

The influence of aspirin treatment on haemostasis is still under debate. There are doubts in emergency operations, especially in transplant patients, concerning dosage and change in medication. Our results are based on an analysis of the therapeutic approaches in German transplantation centres. The question of transplant suitability, dosage and haemostatic effects are discussed with respect to the literature. Some 92.11% of the transplantation centres perform the operation even though the patient has been treated with aspirin. In these cases an increased bleeding tendency is tolerated and observed in 34.2% of the centres. An increased mortality has not been reported. Most of the transplantation centres accept a dosage of 100 mg aspirin daily. Only 7.89% of the transplantation centres refuse to operate on aspirin-treated patients. Correctly indicated aspirin treatment (for cardiac arrhythmia, embolism, or thrombosis, for example) does not contraindicate renal transplantation (daily dosage up to 100 mg). In elective surgery, however, a preoperative change in medication is recommended, e.g., the heparin instead of aspirin.

show abstract

The effects of diflunisal on bleeding time and platelet aggregation in a multidose study

Cited by 8 publications

References 15 publications

Therapeutic Uses of Non-Steroidal Anti-Inflammatory Drugs in Dentistry

Therapeutic Uses of Non-Steroidal Anti-Inflammatory Drugs in Dentistry

Single dose oral diflunisal for acute postoperative pain in adults

The influence of treatment with aspirin in the preoperative management of kidney transplantation?

Contact Info

Product

Resources

About