The effects of different mechanisms on the development of post-ERCP pancreatitis in an ERCP model in rats

Bozkurt, Süleyman; Güner, Ali̇; Kadıoğlu, Hüseyin; Keçe, Can; Reis, Erhan; Coşkun, Halil

doi:10.4318/tjg.2013.0654

Cited by 5 publications

(3 citation statements)

References 32 publications

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“…The leakage might be exacerbated by increased intrapancreatic duct pressure with hyper-secretion of pancreatic juice due to PAR-2 activation ( 21 ), especially under conditions of a disturbed pancreatic juice flow caused by ERCP-induced papillary injury due to direct endoscopic trauma with hemorrhaging or edema ( 6 , 7 ). This hypothesis is consistent with that of a previous report stating that increased intrapancreatic duct pressure is responsible for pancreatic parenchymal damage ( 22 ).…”

Section: Discussionsupporting

confidence: 94%

Use of Nasopancreatic Drainage for Severe Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis: A Case Series

et al. 2018

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Five patients complaining of severe pain due to severe post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) underwent nasopancreatic drainage (NPD) placement. Pain relief was achieved on the second, fourth, and fifth day in three, one, and one patients, respectively. Four patients underwent pancreatic juice culture; all were positive. Our results suggest that NPD can relieve severe PEP with severe pain. Bacteria-induced protease-activated receptor-2 activation may be associated with PEP.

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Section: Discussionsupporting

confidence: 94%

Use of Nasopancreatic Drainage for Severe Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis: A Case Series

et al. 2018

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“…In addition, other studies show that intraductal regulation of pH (Noble et al, 2008) and the mechanical damage caused by direct papillary trauma (Bozkurt et al, 2013) were found to affect the onset of AP, and might be an important factor in PEP. What is more, some studies show that no correlation was detected with increasing pressure or with the use of contrast agent (Haciahmetoglu et al, 2008).…”

Section: Endoscopymentioning

confidence: 99%

Experimental Acute Pancreatitis Models: History, Current Status, and Role in Translational Research

Yang

Yao

et al. 2020

Front. Physiol.

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Acute pancreatitis is a potentially severe inflammatory disease that may be associated with a substantial morbidity and mortality. Currently there is no specific treatment for the disease, which indicates an ongoing demand for research into its pathogenesis and development of new therapeutic strategies. Due to the unpredictable course of acute pancreatitis and relatively concealed anatomical site in the retro-peritoneum, research on the human pancreas remains challenging. As a result, for over the last 100 years studies on the pathogenesis of this disease have heavily relied on animal models. This review aims to summarize different animal models of acute pancreatitis from the past to present and discuss their main characteristics and applications. It identifies key studies that have enhanced our current understanding of the pathogenesis of acute pancreatitis and highlights the instrumental role of animal models in translational research for developing novel therapies.

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“…However, for mechanical, chemical, hydrostatic, enzymatic, infectious, allergic, and thermal mechanisms that are suspected to trigger PEP, evidence demonstrates that one or more of them are responsible for PEP or influence its severity. 4 Several pharmacologic agents have been tried to avoid or alleviate PEP, such as anti-inflammatories (indomethacin and diclofenac), 5 antioxidants (allopurinol and N -acetylcysteine [NAC]), 6 , 7 antibiotics, 8 and epinephrine. 9 Rectal non-steroidal anti-inflammatory drugs are the cornerstone of PEP prevention according to the European Society of Gastrointestinal Endoscopy guidelines.…”

Section: Introductionmentioning

confidence: 99%

Role of vitamin C and rectal indomethacin in preventing and alleviating post-endoscopic retrograde cholangiopancreatography pancreatitis: a clinical study

et al. 2023

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Background/Aims: This study aimed to determine whether vitamin C in addition to indomethacin decreases the occurrence and severity of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) occurrence and severity. Methods: This randomized clinical trial included patients undergoing ERCP. The participants were administered either rectal indomethacin (100 mg) plus an injection of vitamin C (500 mg) or rectal indomethacin (100 mg) alone just before ERCP. The primary outcomes were PEP occurrence and severity. The secondary amylase and lipase levels were determined after 24 hours. Results: A total of 344 patients completed the study. Based on intention-to-treat analysis, the PEP rates were 9.9% for indomethacin plus vitamin C plus indomethacin and 15.7% for indomethacin alone. Regarding the per-protocol analysis, the PEP rates were 9.7% and 15.7% in the combination and indomethacin arms, respectively. There was a remarkable difference between the two arms in PEP occurrence and severity on intention-to-treat or per-protocol analysis (p=0.034 and p=0.031, respectively). The secondary lipase and amylase concentrations were lower in the combination arm than in the indomethacin alone arm (p=0.034 and p=0.029, respectively). Conclusions: Vitamin C injection in addition to rectal indomethacin reduced PEP occurrence and severity

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The effects of different mechanisms on the development of post-ERCP pancreatitis in an ERCP model in rats

Abstract: Girifl ve (s›ras›yla, p=0.551, p=0.031, p=0.0001, p=0.0001, p=0.0001, p=0.0001, p=0.683 excess (p=0.551, p=0.031, p=0.0001, p=0.0001, p=0.0001, p=0.0001, p=0.683, respectively

Cited by 5 publications

References 32 publications

Use of Nasopancreatic Drainage for Severe Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis: A Case Series

Use of Nasopancreatic Drainage for Severe Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis: A Case Series

Experimental Acute Pancreatitis Models: History, Current Status, and Role in Translational Research

Role of vitamin C and rectal indomethacin in preventing and alleviating post-endoscopic retrograde cholangiopancreatography pancreatitis: a clinical study

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