The Effects of Dietary Taurine-Containing Jelly Supplementation on Cognitive Function and Memory Ability of the Elderly with Subjective Cognitive Decline

Bae, Mi Ae; Lee, Eun Seok; Cho, Sung Mo; Kim, Sung Hoon; Chang, Kyung Ja

doi:10.1007/978-3-030-93337-1_37

Cited by 1 publication

(1 citation statement)

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“…Considering the structural similarities between L-glutamate and L-aspartate and the ability of some GADs to use L-aspartate as a substrate 65,68,88 , we examined the possible role of Bf GAD in the production of β-alanine via the decarboxylation of L-aspartate. The neuromodulatory molecules, GABA, taurine and β-alanine generated by glutamate decarboxylases or enzymes similar to GADs, have the ability to reverse cognitive deficits in neurodegenerative disorders like dementia and Alzheimer’s 12,13,24,80,85,86,89,90 . This prompted us to understand the modulation of these molecules by the members of the human gut microbiome.…”

Section: Discussionmentioning

confidence: 99%

Synthesis of versatile neuromodulatory molecules by a gut microbial glutamate decarboxylase

Dadi,

Pauling,

Shrivastava

et al. 2024

Preprint

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Dysbiosis of the microbiome correlates with many neurological disorders, yet very little is known about the chemistry that controls the production of neuromodulatory molecules by gut microbes. Here, we found that an enzyme glutamate decarboxylase (BfGAD) of a gut microbeBacteroides fragilisforms multiple neuromodulatory molecules such as γ-aminobutyric acid (GABA), hypotaurine, taurine, homotaurine, and β-alanine. We evolvedBfGAD and doubled its taurine productivity. Additionally, we increased its specificity towards the substrate L-glutamate. Here, we provide a chemical strategy via which theBfGAD activity could be fine-tuned. In future, this strategy could be used to modulate the production of neuromodulatory molecules by gut microbes.

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