The effects of dietary saturated fat on basal hypothalamic neuroinflammation in rats

Maric, Tia; Woodside, Barbara; Luheshi, Giamal N.

doi:10.1016/j.bbi.2013.09.011

Cited by 72 publications

(63 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is particularly notable in the hypothalamus, where clinical indication of glial activation has been reported (Thaler et al, 2012). Enhanced hypothalamic inflammatory cytokine expression and activation of dependent signaling pathways have also been repeatedly found in diet-induced obesity (DIO) models, both in baseline conditions or following an immune challenge (Andre et al, 2014;Cai and Liu, 2012;De Souza et al, 2005;Gao et al, 2014;Kleinridders et al, 2009;Maric et al, 2014;Pohl et al, 2009;Zhang et al, 2008). Central inflammation in obesity likely results from adiposity-related systemic inflammatory processes or endotoxemia induced by impaired gut permeability, as discussed above.…”

Section: Is Inflammation Linking Fat To Depression?mentioning

confidence: 99%

Role of Adiposity-Driven Inflammation in Depressive Morbidity

Capuron

Lasselin

Castanon

2016

Neuropsychopharmacol

132

View full text Add to dashboard Cite

Depression and metabolic disorders, including overweight and obesity, appear tightly interrelated. The prevalence of these conditions is concurrently growing worldwide, and both depression and overweight/obesity represent substantial risk factors for multiple medical complications. Moreover, there is now multiple evidence for a bidirectional relationship between depression and increased adiposity, with overweight/obesity being associated with an increased prevalence of depression, and in turn, depression augmenting the risk of weight gain and obesity. Although the reasons for this intricate link between depression and increased adiposity remain unclear, converging clinical and preclinical evidence points to a critical role for inflammatory processes and related alterations of brain functions. In support of this notion, increased adiposity leads to a chronic low-grade activation of inflammatory processes, which have been shown elsewhere to have a potent role in the pathophysiology of depression. It is therefore highly possible that adiposity-driven inflammation contributes to the development of depressive disorders and their growing prevalence worldwide. This review will present recent evidence in support of this hypothesis and will discuss the underlying mechanisms and potential therapeutic targets. Altogether, findings presented here should help to better understand the mechanisms linking adiposity to depression and facilitate the identification of new preventive and/or therapeutic strategies.

show abstract

Section: Is Inflammation Linking Fat To Depression?mentioning

confidence: 99%

Role of Adiposity-Driven Inflammation in Depressive Morbidity

Capuron

Lasselin

Castanon

2016

Neuropsychopharmacol

132

View full text Add to dashboard Cite

show abstract

“…Indeed, long chain saturated fatty acids have been shown to directly pass into the hypothalamus producing an inflammatory response there through activation of toll-like receptor 4 signaling. 46,47 This active passage of saturated fatty acids, however, has not been observed in the hippocampus, a key brain region that mediates learning and memory. 46 Nonetheless, high-fat diet consumption has been demonstrated to impair hippocampus-dependent memory function in humans and rodents.…”

Section: Adult Consumption Of a High-fat Diet: A Vulnerability Factormentioning

confidence: 99%

Food for thought: how nutrition impacts cognition and emotion

et al. 2017

View full text Add to dashboard Cite

More than one-third of American adults are obese and statistics are similar worldwide. Caloric intake and diet composition have large and lasting effects on cognition and emotion, especially during critical periods in development, but the neural mechanisms for these effects are not well understood. A clear understanding of the cognitive-emotional processes underpinning desires to over-consume foods can assist more effective prevention and treatments of obesity. This review addresses recent work linking dietary fat intake and omega-3 polyunsaturated fatty acid dietary imbalance with inflammation in developing, adult, and aged brains. Thus, early-life diet and exposure to stress can lead to cognitive dysfunction throughout life and there is potential for early nutritional interventions (e.g., with essential micronutrients) for preventing these deficits. Likewise, acute consumption of a high-fat diet primes the hippocampus to produce a potentiated neuroinflammatory response to a mild immune challenge, causing memory deficits. Low dietary intake of omega-3 polyunsaturated fatty acids can also contribute to depression through its effects on endocannabinoid and inflammatory pathways in specific brain regions leading to synaptic phagocytosis by microglia in the hippocampus, contributing to memory loss. However, encouragingly, consumption of fruits and vegetables high in polyphenolics can prevent and even reverse age-related cognitive deficits by lowering oxidative stress and inflammation. Understanding relationships between diet, cognition, and emotion is necessary to uncover mechanisms involved in and strategies to prevent or attenuate comorbid neurological conditions in obese individuals.

show abstract

“…While HFD in young adults produces low-grade inflammation in the circulation and peripheral tissues (Cano, et al, 2009, Coppack, 2001, Xu, et al, 2002), its ability to directly induce inflammation within the brain is limited to the hypothalamus (De Luca, et al, 2016, Maric, et al, 2014, Milanski, et al, 2009), except after extremely long-term HFD during which diabetes-like symptoms are starting to occur (Jeon, et al, 2012). In the hippocampus, HFD in the young adult is not directly inflammatory and only sensitizes cells to over-respond to future inflammatory stimuli (Sobesky, et al, 2014, Sobesky, et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

High-fat diet and aging interact to produce neuroinflammation and impair hippocampal- and amygdalar-dependent memory

Spencer

D’Angelo

Soch

et al. 2017

Neurobiology of Aging

150

120

View full text Add to dashboard Cite

More Americans are consuming diets higher in saturated fats and refined sugars than ever before, and based on increasing obesity rates, this is a growing trend among older adults as well. While high saturated fat diet (HFD) consumption has been shown to sensitize the inflammatory response to a subsequent immune challenge in young adult rats, the inflammatory effect of HFD in the already-vulnerable aging brain has not yet been assessed. Here, we explored whether short-term (3 days) consumption of HFD would serve as a neuroinflammatory trigger in aging animals, leading to cognitive deficits. HFD impaired long-term contextual (hippocampal-dependent) and auditory-cued fear (amygdalar-dependent) memory in aged, but not young adult rats. Short-term memory performance for both tasks was intact, suggesting that HFD impairs memory consolidation processes. Microglial markers of activation Iba1 and cd11b were only increased in the aged rats, while MHCII was further amplified by HFD. Furthermore, these HFD-induced long-term memory impairments were accompanied by IL-1β protein increases in both hippocampus and amygdala in aged rats. Central administration of IL-1RA in aged rats following conditioning mitigated both contextual and auditory-cued fear memory impairments caused by HFD, strongly suggesting that IL-1β plays a critical role in these effects. Voluntary wheel running, known to have anti-inflammatory effects in the hippocampus, rescued hippocampal-dependent but not amygdalar-dependent memory impairments caused by HFD. Together, these data suggest that short-term consumption of HFD can lead to memory deficits and significant brain inflammation in the aged animal, and strongly suggest that appropriate diet is crucial for cognitive health.

show abstract

The effects of dietary saturated fat on basal hypothalamic neuroinflammation in rats

Cited by 72 publications

References 44 publications

Role of Adiposity-Driven Inflammation in Depressive Morbidity

Role of Adiposity-Driven Inflammation in Depressive Morbidity

Food for thought: how nutrition impacts cognition and emotion

High-fat diet and aging interact to produce neuroinflammation and impair hippocampal- and amygdalar-dependent memory

Contact Info

Product

Resources

About