The effects of dietary phytoestrogens on aromatase activity in human endometrial stromal cells

Edmunds, Katie M.; Holloway, Alison C.; Crankshaw, Denis; Agarwal, Sanjay; Foster, Warren G.

doi:10.1051/rnd:2005055

Cited by 53 publications

(47 citation statements)

References 54 publications

(51 reference statements)

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“…4). Of these, naringenin (5,7,4'-flavanone, 59) has been tested most often and has shown strong to moderate aromatase inhibition activity in microsomal testing [118,119,123,124]. This substance was found to be active in JEG-3 cells [125], Arom+HEK 293 cells [125], and inhibited aromatase at low concentrations in a MCF-7 dual assay for aromatase inhibition and estrogenicity [naringenin (59) was also estrogenic at high concentrations] [116].…”

Section: Natural Product Compounds Tested For Aromatase Inhibitionmentioning

confidence: 99%

Natural Products as Aromatase Inhibitors

Balunas¹,

Su²,

Brueggemeier³

et al. 2008

ACAMC

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With the clinical success of several synthetic aromatase inhibitors (AIs) in the treatment of postmenopausal estrogen receptor-positive breast cancer, researchers have also been investigating also the potential of natural products as AIs. Natural products from terrestrial and marine organisms provide a chemically diverse array of compounds not always available through current synthetic chemistry techniques. Natural products that have been used traditionally for nutritional or medicinal purposes (e.g., botanical dietary supplements) may also afford AIs with reduced side effects. A thorough review of the literature regarding natural product extracts and secondary metabolites of plant, microbial, and marine origin that have been shown to exhibit aromatase inhibitory activity is presented herein. Keywordsaromatase inhibitors; natural products; breast cancer; botanical dietary supplements BREAST CANCERWorldwide breast cancer estimates included over one million incident cases and almost 400,000 deaths in the year 2000 [1,2]. In the United States, over 178,000 women were expected to be diagnosed with breast cancer in 2007 with over 40,000 deaths occurring from the disease [3]. In developed countries, mortality from breast cancer has recently begun to decline, primarily due to earlier detection and improved treatments [4,5]. Breast cancer is thought to be a result of inherited genetic predisposition (e.g., mutations in genes such as BRCA-1, p53, PTEN/MMAC1, and/or ATM) and/or environmental factors (e.g., radiation exposure, dietary factors, alcohol consumption, hormonal exposure) [2,6,7]. Numerous genetic mutations are necessary for breast cancer development and progression including the acquisition of the capabilities for self-sufficiency in growth signals, insensitivity to anti-growth signals, evasion of apoptosis, limitless replicative potential, sustained angiogenesis, and tissue invasion and metastasis, known collectively as the "hallmarks of cancer" [8].Numerous molecular targets have been identified as playing a significant role in breast cancer development and progression. Estrogens and the estrogen receptors (ERs) are widely NIH Public Access Author ManuscriptAnticancer Agents Med Chem. Author manuscript; available in PMC 2011 April 12.Published in final edited form as:Anticancer Agents Med Chem. 2008 August ; 8(6): 646-682. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript recognized to play an important role in the development and progression of breast cancer, making estrogens and the ERs widely studied molecular targets [9][10][11][12]. Two of the endogenous estrogens found in humans include estradiol and estrone. In pre-menopausal women, estrogens are produced primarily through conversion of androgens in the ovaries while estrogen production in postmenopausal women occurs in only peripheral tissues [13,14]. Estrogens have various effects throughout the body, including positive effects on the brain, bone, heart, liver, and vagina, with negative effects such as increased risk...

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Section: Natural Product Compounds Tested For Aromatase Inhibitionmentioning

confidence: 99%

Natural Products as Aromatase Inhibitors

Balunas¹,

Su²,

Brueggemeier³

et al. 2008

ACAMC

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“…Phytoestrogens are generally considered to be selective ER modulators, have a high affinity for the nuclear hormone receptor ER-b, and have been reported to inhibit aromatase activity (the rate-limiting enzyme in the conversion of androgens to estrogens) in human endometrial stromal cells (36). Thus, it is not unexpected that dietary phytoestrogens could play a role in the pathophysiology of an estrogen-dependent (37) condition such as endometriosis.…”

Section: Discussionmentioning

confidence: 99%

Urinary Phytoestrogen Concentrations Are Not Associated with Incident Endometriosis in Premenopausal Women

Weck

Louis

2017

The Journal of Nutrition

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“…Several dietary agents including quercetin, genistein, daidzein and resveratrol have shown to be effective aromatase inhibitors in cancers [25][26][27][28][29]. Resveratrol from Mentha piperita has been shown to be effective inhibitors of several growth factor signaling pathways [30].…”

Section: Pc-3 Pc-14mentioning

confidence: 99%

Investigation of aromotase inhibition by several dietary vegetables in human non-small cell lung cancer cell lines

Çelik¹,

Akça²,

Sen³

2013

Turk J Bioch

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Objective: In this study we have investigated the effect of extracts obtained from well-known vegetable diets consumed commonly in Mediterranean and Aegean regions of Turkey on the expression of aromatase at protein, mRNA and activity levels in human non-small cell lung cancer cells-PC-3 and PC-14 cell lines. Method: For this purpose, cytotoxicity was determined by using crystal violet stain. In vivo and in vitro aromatase activity was determined flourometrically. The expression of aromatase in protein and mRNA levels was detected by Western blotting using anti-hCYP19 and reverse transcriptase-polymerase chain reaction using suitable primers, respectively. Result: Extracts obtained from Laurus nobilis, Mentha piperita, Crocus sativus reduced aromatase activity 32%, 44%, 36% and 42%, 32%, 56% in PC-14 and PC-3 cell lines, respectively, no significant changes were observed in protein and mRNA levels. Whereas extract obtained from Allium porrum decreased aromatase activity and mRNA level only in PC-14 cell lines by 52% and 2,5-fold, respectively, without significant influence on aromatase protein level. Conclusion:The results obtained in this study have shown that Laurus nobilis, Mentha piperita, Crocus sativus and Allium porrum do contain effective aromatase inhibitors. Therefore, further studies investigating the content of these vegetables are necessary to understand the potential role and mechanism of action of these foods in reducing the risk of non-small cell lung carcinomas.

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The effects of dietary phytoestrogens on aromatase activity in human endometrial stromal cells

Cited by 53 publications

References 54 publications

Natural Products as Aromatase Inhibitors

Natural Products as Aromatase Inhibitors

Urinary Phytoestrogen Concentrations Are Not Associated with Incident Endometriosis in Premenopausal Women

Investigation of aromotase inhibition by several dietary vegetables in human non-small cell lung cancer cell lines

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