The Effects of Dietary Nutrition on Sleep and Sleep Disorders

Zhao, Mingxia; Tuo, Houzhen; Wang, Shuhui; Zhao, Lin

doi:10.1155/2020/3142874

Cited by 107 publications

(96 citation statements)

References 80 publications

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“…The mechanisms underlying the effects of dietary ω-6 fatty acids on sleep disorders remain unclear. One potential explanation is that ω-6 fatty acids serve as precursors of eicosanoids, a lipid mediator that shows a pro-inflammatory tendency [ 38 , 52 ], and inflammation response may increase the risk of sleep disorders [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

“…Few studies have investigated the association between ω-6 fatty acids and sleep, and the results were inconsistent. A recent cross-sectional study did not detect a significant association between erythrocyte membrane ω-6 fatty acids levels and sleep disorders in Chinese children and adolescents [ 32 ], whereas animal experiments have shown that prostaglandin D2 and E2 derived from arachidonic acid are very important sleep regulators [ 38 , 39 ]. In addition, the ratio of ω-6: ω-3 is commonly used to describe fatty acid composition.…”

Section: Introductionmentioning

confidence: 99%

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Associations of Dietary ω-3, ω-6 Fatty Acids Consumption with Sleep Disorders and Sleep Duration among Adults

Luo

Sun

et al. 2021

Nutrients

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The relationship between ω-3 and ω-6 fatty acids consumption and sleep disorders or duration are controversial. Therefore, we used the data of the National Health and Nutrition Examination Survey 2007–2016 in this cross-sectional study to explore their relationships. ω-3 and ω-6 fatty acids consumption was assessed using two 24 h dietary recall interviews. Sleep disorders and sleep duration were based on self-reported data. Logistic regression models and restricted cubic spline analyses were used. Compared with tertile one, the odds ratios (ORs) and 95% confidence intervals (CIs) of sleep disorders for the second tertile of ω-6 fatty acid intake and the highest tertile of ω-6:ω-3 ratio were 1.30 (1.04–1.62) and 1.36 (1.08–1.70), respectively. Inverse U-shaped and linear dose–response relationships were observed between dietary ω-6 fatty acid intake and ω-6:ω-3 ratio and sleep disorders, respectively. In addition, ω-3 fatty acid consumption was adversely related to sleep disorders in men and the OR (95% CI) was 0.68 (0.49–0.95). Compared with normal sleep duration, ω-3 fatty acid consumption was negatively related to very short, short, and long sleep duration risk. The relative risk ratios (RRRs) were 0.53 (0.35–0.81), 0.79 (0.67–0.93), and 0.81 (068–0.98), respectively. The RRR of very short sleep for ω-6 fatty acid consumption was 0.57 (0.45–0.73). Our study indicates that ω-6 fatty acid consumption and the ω-6:ω-3 ratio are positively associated with the risk of sleep disorders, while the negative association between ω-3 fatty acids and sleep disorders may exist only in men. Furthermore, ω-3 and ω-6 fatty acid consumption are negatively related to the risk of non-normal sleep duration.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Associations of Dietary ω-3, ω-6 Fatty Acids Consumption with Sleep Disorders and Sleep Duration among Adults

Luo

Sun

et al. 2021

Nutrients

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“…15 Oral vitamin B12 dose of 1.5 mg once a day or three times a day or was used, however, in these relatively small studies, the baseline vitamin B12 level was not recorded. 16 Although the effects of vitamin B 12 on sleep are yet to be fully clarified, vitamin B12 deficiency should be considered as a possible contributory factor for insomnia, especially when other risk factors for this deficiency are present in the history obtained from the patient. 17…”

Section: Discussionmentioning

confidence: 99%

The vegetarian who could not sleep: a case report

Sumathipala¹

2020

Int J Res Med Sci

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Sleep disorders are not unusual presentations to family medicine clinicians. Similarly, patients may have diets that can render them susceptible to vitamin deficiencies. Although not a commonly considered risk factor for sleep disorders, vitamin B12 is involved in the production of melatonin, a hormone regulating the sleep-wake cycle, and supplementation of vitamin B12 has been used to treat sleep disorders. This case study described a patient who presented with a sleep disorder and who was a vegetarian. Although he lacked obvious manifestations of vitamin B12 deficiency, his serum level was almost half the lower limit of normal, and with vitamin B12 supplementation, his sleep improved.

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“…І хоча в деяких дослідженнях не виявлено значного впливу піридоксину на якість нічного сну [1,40], проте в комплексі з іншими біоак тивними речовинами піридоксин здатен потен ціювати дію останніх.…”

Section: рисunclassified

Use of alpha-casozepine (Lactium®) and vitamin B6 in clinical practice (literature review)

Marushko¹,

Hyshchak²

2021

MPU

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The article summarizes the literature data on the use of alpha-casozepine and its combination with vitamin B6 in clinical practice. It has been found that the properties of alpha-casozepine are similar to those of the benzodiazepine family of drugs, with the exception of such concomitant side effects of these drugs as addiction or sedation. Therefore, today alpha-casozepine has been increasingly used as a dietary supplement to improve sleep and to relieve stress disorders. The anxiolytic effects of alpha-casozepine have been confirmed in many experimental models over the past 20 years. It has been found that alpha-casozepin affects sleep by modulating its architecture, but has almost no sedative effect, which makes it similar to melatonin since both facilitate, rather than induce, sleep. The effect of alpha-casozepine on sleep is associated with GABA receptors. It was found that with transport of the peptide across the blood-brain barrier, the C-terminal residue of tryptophan, a precursor of serotonin, is released, which is an important neurotransmitter in the regulation of mood and satiety. Direct modulation of GABA receptors by alpha-casozepin, including in the neurons of the hypothalamus, has been proven. According to the results of clinical trials, alpha-casozepine has a positive effect on both physical and psychological symptoms of anxiety. It has been shown that the use of alpha-casozepine promotes faster recovery after a stress response, which is manifested by lower blood pressure and heart rate during the relaxation period (after stress) compared with the rest period (before stress induction). Studies show that anxiolytic peptides derived from milk are promising for use in a wide range of functional disorders of the nervous system, sleep disorders, anxiety, in the treatment of patients with arterial dystonia, including in childhood. It is worth noting the use of a combination of alpha-casozepine (Lactium®) and vitamin B6, including in children, because such a combination promotes good absorption of the drug and a positive effect on the nervous system. No conflict of interest was declared by the authors. Key words: alpha(casozepine, lactium, anxiety, sleep.

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The Effects of Dietary Nutrition on Sleep and Sleep Disorders

Cited by 107 publications

References 80 publications

Associations of Dietary ω-3, ω-6 Fatty Acids Consumption with Sleep Disorders and Sleep Duration among Adults

Associations of Dietary ω-3, ω-6 Fatty Acids Consumption with Sleep Disorders and Sleep Duration among Adults

The vegetarian who could not sleep: a case report

Use of alpha-casozepine (Lactium®) and vitamin B6 in clinical practice (literature review)

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