The effects of dietary lipids on gene expression and apoptosis

Fernandes, Gabriel; Troyer, Dean A.; Jolly, Christopher A.

doi:10.1079/pns19980080

Cited by 28 publications

(12 citation statements)

References 57 publications

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“…Lipid peroxidation, the oxidation of long-chain PUFAs, can produce an array of secondary products of lipid oxidation that may possess cytostatic or cytolytic capacity. It has been proposed that DHA and EPA can both directly and indirectly modulate gene expression (38). The direct effects of DHA and EPA are most probably mediated by their ability to bind to positive and/or negative regulatory transcription factors, whereas the indirect effects appear to be mediated through alterations in the generation of intracellular lipid second messengers.…”

Section: Discussionmentioning

confidence: 99%

Omega-3 Fatty Acids and a Novel Mammary Derived Growth Inhibitor Fatty Acid Binding Protein MRG in Suppression of Mammary Tumor

Liu¹

2002

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Section: Discussionmentioning

confidence: 99%

Omega-3 Fatty Acids and a Novel Mammary Derived Growth Inhibitor Fatty Acid Binding Protein MRG in Suppression of Mammary Tumor

Liu¹

2002

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“…the oxidation of long-chain PUFAs, can produce an array of secondary products of lipid oxidation that may possess cytostatic or cytolytic capacity. It has been proposed that DHA and EPA can both directly and indirectly modulate gene expression (38). The direct effects of DHA and EPA are most probably mediated by their ability to bind to positive and/or negative regulatory transcription factors, whereas the indirect effects appear to be mediated through alterations in the generation of intracellular lipid second messengers.…”

Section: Discussionmentioning

confidence: 99%

Breast Cancer Prevention by Hormonally Induced Mammary Gland Differentiation: The Role of a Novel Mammary Growth Inhibitor and Differentiation Factor MRG

Shi¹

2001

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204. Arlington, VA 22202-4302, and PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES)Long Island Jewish Medical Center New Hyde Park, New York 11040 E-Mail: shi@lij.edu SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES)U AbstractWe have previously identified and characterized a novel tumor growth inhibitor and a fatty acid binding protein in human mammary gland and named it as Mammary derived growth inhibitor Related Gene MRG. MRG has tumor-suppressing activities; it inhibits breast cancer cell growth in vitro and tumor growth in vivo. Here, the effects of MRG on mammary gland differentiation and its interaction with o>3 polyunsaturated fatty acids (o>3 PUFA) on growth inhibition were investigated. MRG protein expression was associated with human mammary gland differentiation with the highest expression observed in the differentiated alveolar mammary epithelial cells from the lactating gland. Overexpression of MRG in human breast cancer cells induced differentiation with changes in cellular morphology and a significant increase in the production of lipid droplets. Treatment of mouse mammary gland in organ culture with MRG protein resulted in a differentiated morphology and stimulation of ß-casein expression. Treatment of human breast cancer cells with u>3 PUFA DHA resulted in a differential growth inhibition proportional to their MRG expression. MRG transfected cells or MRG protein treated cells were much more sensitive to DHA-induced growth inhibition compared with MRG negative or control non-treated cells. Our results suggest that MRG is a candidate mediator of the differentiating effect of pregnancy on breast epithelial cells and may play a major role in u>3 PUFA-mediated tumor suppression.

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“…The direct effects of EPA and DHA are most probably mediated by their ability to bind to positive and/or negative regulatory transcription factors, while the indirect effects appear to be mediated through alterations in the generation of intracellular lipid second messengers, e.g. diacylglycerol and ceramide [48]. There is also evidence that PUFAs can interact directly with nuclear receptor proteins such as the peroxisome proliferator-activated receptor (PPAR) [49].…”

Section: Potential Mechanisms Whereby Pufas Mediate Their Vital Wide-mentioning

confidence: 99%

Modulation of immune cell function by polyunsaturated fatty acids

2005

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The n-3 and n-6 polyunsaturated fatty acids (PUFAs) are essential dietary constituents. They are important as a source of energy, as structural components of cell membranes, and as signalling molecules. They have been demonstrated to be potent modulators of the immune response, and research has endeavoured to optimise the ratio of n-3 to n-6 PUFAs in the lipid component of total parenteral nutrition (TPN) to optimise their beneficial effects in the clinical setting. Critically ill neonates on TPN have an increased incidence of sepsis, and additional studies have determined that lipid emulsions depress various elements of cellular immune responses in monocytes, lymphocytes, and neutrophils. It has been proposed that PUFAs may mediate their manifold effects through the modification of eicosanoid production and by directly or indirectly modifying intracellular signal transduction pathways, including the alteration of gene transcription, in various tissues. They are susceptible to lipid peroxidation, and there is evidence that the products of this process may result in cell death by apoptosis, a nonphlogistic homeostatic process of cell deletion. PUFAs have been shown to induce apoptosis in primary lymphocytes, colonic mucosal cells, and various cell lines. Additionally, our laboratory has shown them to be potent inducers of apoptosis in neonatal monocytes. This may represent a novel mechanism whereby PUFAs may modify the immune response.

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The effects of dietary lipids on gene expression and apoptosis

Cited by 28 publications

References 57 publications

Omega-3 Fatty Acids and a Novel Mammary Derived Growth Inhibitor Fatty Acid Binding Protein MRG in Suppression of Mammary Tumor

Omega-3 Fatty Acids and a Novel Mammary Derived Growth Inhibitor Fatty Acid Binding Protein MRG in Suppression of Mammary Tumor

Breast Cancer Prevention by Hormonally Induced Mammary Gland Differentiation: The Role of a Novel Mammary Growth Inhibitor and Differentiation Factor MRG

Modulation of immune cell function by polyunsaturated fatty acids

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