The effects of dietary flavonoids on the regulation of redox inflammatory networks

Izzi, Valerio; Masuelli, Laura; Tresoldi, Ilaria; Sacchetti, Paola; Modesti, Andrea; Galvano, Fabio; R, Bei

doi:10.2741/4061

Cited by 118 publications

(79 citation statements)

References 109 publications

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“…Flavonoids may exert anti-inflammatory actions via their ability to inhibit reactive oxygen or nitrogen compounds (Izzi et al, 2012), inhibiting MC activation (Kimata et al, 2000). The flavone luteolin can inhibit MCs and keratinocytes (Weng et al, 2014b).…”

Section: Treatmentmentioning

confidence: 99%

Fibromyalgia Syndrome in Need of Effective Treatments

Theoharides

Tsilioni

Arbetman

et al. 2015

J Pharmacol Exp Ther

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Fibromyalgia syndrome (FMS) is a chronic, idiopathic condition of widespread musculoskeletal pain, affecting primarily women. It is clinically characterized by chronic, nonarticular pain and a heightened response to pressure along with sleep disturbances, fatigue, bowel and bladder abnormalities, and cognitive dysfunction. The diagnostic criteria have changed repeatedly, and there is neither a definitive pathogenesis nor reliable diagnostic or prognostic biomarkers. Clinical and laboratory studies have provided evidence of altered central pain pathways. Recent evidence suggests the involvement of neuroinflammation with stress peptides triggering the release of neurosenzitizing mediators. The management of FMS requires a multidimensional approach including patient education, behavioral therapy, exercise, and pain management. Here we review recent data on the pathogenesis and propose new directions for research and treatment.

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Section: Treatmentmentioning

confidence: 99%

Fibromyalgia Syndrome in Need of Effective Treatments

Theoharides

Tsilioni

Arbetman

et al. 2015

J Pharmacol Exp Ther

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“…[42] Preliminary studies indicate that flavonoids may affect anti-inflammatory mechanisms via their ability to inhibit reactive oxygen or nitrogen compounds. [43] Flavonoids have also been…”

Section: World Journal Of Pharmaceutical Researchmentioning

confidence: 99%

“…proposed to inhibit the pro-inflammatory activity of enzymes involved in free radical production, such as cyclooxygenase, lipoxygenase or inducible nitric oxide synthase, [43] [44] and to modify intracellular signaling pathways in immune cells, [43] or in brain cells after a stroke. [45] Procyanidins, a class of flavonoids, have been shown in preliminary research to have antiinflammatory mechanisms including modulation of the arachidonic acid pathway, inhibition of gene transcription, expression and activity of inflammatory enzymes, as well as secretion of anti-inflammatory mediators.…”

Section: World Journal Of Pharmaceutical Researchmentioning

confidence: 99%

Flavonoids

Waghmare¹

2017

WJPR

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“…Flavonoids are classified into the 7 major subgroups by their chemical structure including flavanols, flavanones, flavonols, flavones, flavanonols, isoflavones, and anthocyanins [32,33]. Apart from their antioxidant properties, they have got considerable attention due to other health promoting benefits for antiviral, antiallergic, antiplatelet, antiinflammatory, and antitumor activities [34].…”

Section: Characterizing Phenolic Compounds Of Lyophilized Tt Leaves Jmentioning

confidence: 99%

Some Phytochemicals and Anti-inflammation Effect of Juice from <i>Tiliacora triandra</i> Leaves

Weerawatanakorn¹,

Rojsuntornkitti²,

Pan³

et al. 2018

JFNR

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Tiliacora triandra (TT), native to Southeast Asia, has been widely used as folk medicine and in cuisines in many areas. Although little scientific evidence supports the health benefits of TT leaves, the juice extracted from TT leaves has become popular for consumers among all socioeconomic classes. Thus, this study aims to evaluate the phytochemical profile and anti-inflammatory properties of juice extracted from TT leaves. The result revealed that, the highest total phenolic contents (199.92 mg GAE/g), total flavonoid contents (29.76 mg RUE/g), and extraction yield (61.2%) of the lyophilized TT leaves juice powder were found in the solvent mixture of ethanol, water, and acetone extracts. The highest DPPH radical scavenging value (90.95%) of the lyophilized TT leaves juice powder was found in hot water extract. By HPLC analysis, total phenolic compounds of the lyophilized TT leaves juice powder was 3,938.1 mg/kg. Tannic acid, gallic acid, and rutin are the major phenolic compound and the juice is a rich source of chlorophyll compound (3,551.6 mg/kg). The lyophilized TT leaves juice down-regulated the induction of inflammatory iNOS and COX-2 proteins in LPS-stimulated macrophages. The results suggest that intake of TT leaves juice, providing various phenolic and chlorophyll compounds, has great potential for reducing the inflammatory process.

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The effects of dietary flavonoids on the regulation of redox inflammatory networks

Cited by 118 publications

References 109 publications

Fibromyalgia Syndrome in Need of Effective Treatments

Fibromyalgia Syndrome in Need of Effective Treatments

Flavonoids

Some Phytochemicals and Anti-inflammation Effect of Juice from <i>Tiliacora triandra</i> Leaves

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