The Effects of Dietary Fat and Calorie Density on Esophageal Acid Exposure and Reflux Symptoms

Fox, Mark; Barr, Carole; Nolan, Suzanne O.; Lomer, Miranda; Anggiansah, Angela; Wong, Terry

doi:10.1016/j.cgh.2006.12.013

Cited by 105 publications

(87 citation statements)

References 31 publications

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“…Fox et al have shown in 15 GERD patients that frequency of reflux symptoms was increased by high-fat diet as compared to low-fat diet and was not affected by caloric density of a meal [42]. In contrast, calorie density determined the severity of esophageal acid exposure that was not affected by the level of fat content.…”

Section: Dietmentioning

confidence: 96%

The Pathophysiological Mechanisms of GERD in the Obese Patient

Fass

2008

Dig Dis Sci

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Obesity has increased dramatically in the last 30 years, affecting 33% of the adult population in the United States. Increase in body mass index has been shown to be associated with the increase in the prevalence of gastroesophageal reflux disease (GERD) symptoms, esophageal mucosal injury, and GERD complications. The putative mechanisms responsible for the close relationship between GERD and increased body mass index include increased intragastric pressure, increased gastroesophageal pressure gradient, esophageal motor and sensory abnormalities, increase in prevalence of hiatal hernia, increase in serum female hormonal levels, diet, and increase in comorbidities. Whilst the current efforts are to focus on one major underlying mechanism, it is highly likely that multiple factors contribute to the increased prevalence of GERD in the obese patient.

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Section: Dietmentioning

confidence: 96%

The Pathophysiological Mechanisms of GERD in the Obese Patient

Fass

2008

Dig Dis Sci

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“…Results from recent studies that have addressed the role of fat on GERD suggest that intraduodenal fat not only increases the proportion of transient LES relaxations accompanied by reflux [17] but also intensifies the perception of heartburn [18,19]. Another study showed that among all dietary nutrients, cholesterol enhances most the perception of acid reflux events [20].…”

Section: Introductionmentioning

confidence: 95%

Heartburn and Regurgitation in Pregnancy: The Effect of Fat Ingestion

et al. 2009

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“…34 Although no definite data exist regarding the role of diet in GERD, 35,36 high-fat diet is frequent in the obese patients and appears to induce GER by itself. 37 Thus, the different lifestyle, in particular diet, may cause ethnic and geographic differences in GERD. In addition, the higher prevalence of Helicobacter pylori and atrophic gastritis in East Asian countries may be another factor in the lower prevalence of GERD.…”

mentioning

confidence: 99%

Recurrence and Its Impact on the Health-related Quality of Life in Patients with Gastroesophageal Reflux Disease: A Prospective Follow-up Analysis

Shin

Cheon

et al. 2015

J Neurogastroenterol Motil

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Background/AimsLimited data exist on the outcome of gastroesophageal reflux disease (GERD) treatment and its impact on the health-related quality of life (HRQoL) in the Asian population. This study aims to evaluate the treatment outcomes, to investigate the factors associated with recurrence, and to evaluate the impact of the treatment outcome on the HRQoL in a Korean GERD population. MethodsThis was a prospective, multicenter study involving a total of 824 GERD patients. The response to treatment was assessed at week 4 (or week 8 for the patients who did not achieve complete resolution [CR] at week 4). The EQ-5D questionnaire was used at baseline, end of treatment, and first recurrence to assess the HRQoL. To assess GERD symptoms, contact of patients by phone at 1, 6, and 12 months following treatment was carried out. ResultsCR was achieved in 65.6% and recurrence was observed in 47.8% following treatment. CR and recurrence rates did not differ by the presence of esophagitis. Multivariate analysis revealed that acid regurgitation (odds ratio 2.249; 95% confidence interval 1.293-3.912; P = 0.004) and both acid regurgitation and heartburn (odds ratio 2.330; 95% confidence interval 1.392-3.901; P = 0.001) were independent risk factors for GERD recurrence. EQ-5D scores were more improved in patients with CR than in those without CR, and worsened more during follow-up in patients with recurrence than in those without recurrence. ConclusionsWe should achieve complete symptom relief and attempt to prevent recurrence in GERD patients to improve their HRQoL.

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The Effects of Dietary Fat and Calorie Density on Esophageal Acid Exposure and Reflux Symptoms

Cited by 105 publications

References 31 publications

The Pathophysiological Mechanisms of GERD in the Obese Patient

The Pathophysiological Mechanisms of GERD in the Obese Patient

Heartburn and Regurgitation in Pregnancy: The Effect of Fat Ingestion

Recurrence and Its Impact on the Health-related Quality of Life in Patients with Gastroesophageal Reflux Disease: A Prospective Follow-up Analysis

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