The effects of diet quality and dietary acid load on insulin resistance in overweight children and adolescents

Caferoğlu, Zeynep; Erdal, Busra; Hatipoğlu, Nihal; Kurtoğlu, Selim

doi:10.1016/j.endien.2022.06.001

Cited by 5 publications

(3 citation statements)

References 32 publications

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“…A high DAL has been associated with insulin resistance and an increased risk for type 2 diabetes (T2DM) in various large epidemiological cohort studies, including the Teheran Lipid and Glucose Study (76) , the Nurses’ Health Study I and II and the Health Professionals’ Follow-up Study (77) . Such associations have been found in both children/adolescents (78) and adults (79) . A high DAL is not only associated with higher fasting blood glucose levels (80) but also with impaired insulin sensitivity (14,81) .…”

Section: Introductionmentioning

confidence: 62%

Observational and clinical evidence that plant-based nutrition reduces dietary acid load

2022

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Contemporary diets in Western countries are largely acid-inducing and deficient in potassium alkali salts, resulting in low-grade metabolic acidosis. The chronic consumption of acidogenic diets abundant in animal-based foods (meats, dairy, cheese and eggs) poses a substantial challenge to the human body's buffering capacities and chronic retention of acid wherein the progressive loss of bicarbonate stores can cause cellular and tissue damage. An elevated dietary acid load (DAL) has been associated with systemic inflammation and other adverse metabolic conditions. In this narrative review, we examine DAL quantification methods and index observational and clinical evidence on the role of plant-based diets, chiefly vegetarian and vegan, in reducing DAL. Quantitation of protein and amino acid composition and of intake of alkalising organic potassium salts and magnesium show that plant-based diets are most effective at reducing DAL. Results from clinical studies and recommendations in the form of expert committee opinions suggest that for a number of common illnesses, wherein metabolic acidosis is a contributing factor, the regular inclusion of plant-based foods offers measurable benefits for disease prevention and management. Based on available evidence, dietary shifts toward plant-based nutrition effectively reduces dietary-induced, low-grade metabolic acidosis.

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Section: Introductionmentioning

confidence: 62%

Observational and clinical evidence that plant-based nutrition reduces dietary acid load

2022

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“…In a multivariate adjusted model, compared to the women in the lowest quartile, those in the highest DAL quartile had the highest CRP (30–33%) and highest levels of HgA1c (6–9%) [ 46 ]. Similarly, in a study of 135 children and adolescents, those with the lowest DAL (as assessed by 3-day food records and dietary estimations of their DAL) had the lowest HOMA-IR [ 47 ].…”

Section: Evidence That Bicarbonate Treatment Improves Insulin Signalingmentioning

confidence: 99%

Effects of Alterations in Acid–Base Effects on Insulin Signaling

Frassetto,

Masharani

2024

IJMS

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Insulin tightly regulates glucose levels within a narrow range through its action on muscle, adipose tissue and the liver. The activation of insulin receptors activates multiple intracellular pathways with different functions. Another tightly regulated complex system in the body is acid–base balance. Metabolic acidosis, defined as a blood pH < 7.35 and serum bicarbonate < 22 mmol/L, has clear pathophysiologic consequences including an effect on insulin action. With the ongoing intake of typical acid-producing Western diets and the age-related decline in renal function, there is an increase in acid levels within the range considered to be normal. This modest increase in acidosis is referred to as “acid stress” and it may have some pathophysiological consequences. In this article, we discuss the effects of acid stress on insulin actions in different tissues.

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“…También, cabe mencionar que en el estudio realizado en el año 2018 por Serrano et al se considera que el principal estilo de vida no saludable es la obesidad en niños y adolescentes, la misma que se relaciona por la falta de lactancia materna en niños de 0 a 6 meses, representando una de las condiciones que predispone a la enfermedad, por lo tanto, en este estudio existe un 75% de niños que padecen sobrepeso y obesidad, el mismo que coincide con el estudio de Pérez -Cruz et al (16)(17)(18).…”

Section: Reflexiones Finalesunclassified

Etiología, diagnóstico y tratamiento de la resistencia a la insulina. Revisión sistemática

Coronel González,

Calle Gutiérrez

2023

Temas De Guardia en Medicina: Volumen 1

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The effects of diet quality and dietary acid load on insulin resistance in overweight children and adolescents

Cited by 5 publications

References 32 publications

Observational and clinical evidence that plant-based nutrition reduces dietary acid load

Observational and clinical evidence that plant-based nutrition reduces dietary acid load

Effects of Alterations in Acid–Base Effects on Insulin Signaling

Etiología, diagnóstico y tratamiento de la resistencia a la insulina. Revisión sistemática

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