The effects of diamine oxidase administration on experimental ulcerative colitis in rats

Fogel, W. A.; Lewiński, Andrzej

doi:10.1007/s00011-005-0044-y

Cited by 8 publications

(7 citation statements)

References 8 publications

(16 reference statements)

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“…In particular, evidence has been offered that mast cell-derived inflammatory mediators, including histamine, play a major pathogenic role in these diseases. Fogel et al [46,47], using a model of ulcerative colitis in rats, demonstrated an overall improvement and reduction of the local inflammatory reaction after treatment with DAO from pig kidney immobilized on concanavalin A sepharose [46,47]. In particular, histopathologic changes in the colon of DAO-pretreated rats were markedly blunted, as were plasma ceruloplasmin activity and tissue myeloperoxidase [47].…”

Section: Role Of Diamine Oxidases In Anaphylaxismentioning

confidence: 98%

“…Fogel et al [46,47], using a model of ulcerative colitis in rats, demonstrated an overall improvement and reduction of the local inflammatory reaction after treatment with DAO from pig kidney immobilized on concanavalin A sepharose [46,47]. In particular, histopathologic changes in the colon of DAO-pretreated rats were markedly blunted, as were plasma ceruloplasmin activity and tissue myeloperoxidase [47]. These studies highlight the pivotal role of histamine in inflammatory bowel diseases, as well as the role of histaminase in controlling the levels of histamine in tissues and blood.…”

Section: Role Of Diamine Oxidases In Anaphylaxismentioning

confidence: 99%

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Pea Seedling Histaminase as a Novel Therapeutic Approach to Anaphylactic and Inflammatory Disorders

Masini

Bani

Marzocca

et al. 2007

The Scientific World JOURNAL

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Amine oxidases (AOs) are ubiquitous enzymes involved in the metabolism of biogenic amines. Copper AOs (Cu-AOs) catalyze the oxidative deamination of primary amine groups of several biogenic amines, such as putrescine, cadaverine, and histamine. In the present review, the effects of a plant amine oxidase (Cu-AO, histaminase, EC1.4.3.6) purified from pea seedlings in the modulation of IgE-mediated allergic reactions, and in the prevention of cardiac and splachnic postischemic reperfusion damage are reported.

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Section: Role Of Diamine Oxidases In Anaphylaxismentioning

confidence: 98%

Section: Role Of Diamine Oxidases In Anaphylaxismentioning

confidence: 99%

Pea Seedling Histaminase as a Novel Therapeutic Approach to Anaphylactic and Inflammatory Disorders

Masini

Bani

Marzocca

et al. 2007

The Scientific World JOURNAL

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“…They can be caused by adverse reaction to irritants, enzymatic or pharmacological causes: the concurrent presence of more than one of the causative factors may enhance the severity of histamine intoxication [29][30][31][32][33][34]. There is an increased risk of histamineinduced adverse reactions in humans with decreased amine oxidase activity and/or increased gut permeability, as in subjects with colitis ulcerosa or Crohn's disease [25,32,33]. Reduced histamine degradation capacity was disclosed also in a subgroup of patients with atopic eczema [34].…”

Section: Non-allergic Food Hypersensitivity (Food Intolerance)mentioning

confidence: 84%

“…Ingested histamine is catabolized not only by DAO but also by HNMT, as both are present in the small and large bowel [2,8,[21][22][23]. Several results suggest that DAO is a secretory protein, which operates in microvascular endothelium and is responsible for scavenging extracellular histamine [21][22][23][24][25], whereas HNMT is a cytosolic enzyme, metabolizing histamine in the intracellular space [2,8,13,14]. Although plasma membrane transporters for scavenging and recycling dopamine, noradrenaline, adrenaline and serotonin from the extracellular space (abbreviated DAT, NAT and SERT respectively) are well known and characterized [26], only recently have organic cation transporters OCT-2 and OCT-3 been suggested to facilitate the intracellular metabolism of histamine by HNMT [27].…”

Section: Metabolism Of Dietary Aminesmentioning

confidence: 99%

Histamine in food: is there anything to worry about?

Fogel

Lewiński

Jochem

2007

Biochemical Society Transactions

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Biogenic mono-, di- and poly-amines are widely distributed among living organisms. The amines fulfil many important functions in the human body both in the periphery and brain. Some authors suggest that foods rich in biogenic amines, especially histamine, present high health hazards for consumers. However, this is conditional on a range of other factors. The alimentary tract is well equipped with enzymes that inactivate amines and the blood-brain barrier prevents them entering the brain from the circulation. Oxidative deamination, methylation, acetylation and transglutamylation are the degradation pathways which operate efficiently in the stomach, intestines and liver. Particularly important is oxidative deamination. Food histamine poisoning or cheese reaction, manifested itself in patients treated with drugs that inhibit amine oxidases or in patients showing an enterocytic diamine oxidase deficit. It is rather food allergy, which should worry us more, as endogenous histamine release from mast cells is more dangerous. Preventive measures should be undertaken against increases in food allergies.

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“…Plant histaminase has also some beneficial effects in asthma-like reaction [18], or in splanchnic artery occlusion/reperfusion injury [19]. As histamine and reactive oxygen species are involved in the pathophysiology of inflammatory bowel disease, hog kidney DAO had been intraperitoneally administered on experimental ulcerative colitis in rats [20], and the DAO treatment positively modified the inflammatory reaction. Thus, it is also expected that exogenous DAO could protect against oxidative damage [17–19], as reactive species also play an important role in inflammatory diseases.…”

Section: Introductionmentioning

confidence: 99%

Zymographic assay of plant diamine oxidase on entrapped peroxidase polyacrylamide gel electrophoresis. A study of stability to proteolysis

Calinescu

Federico²,

Mondovı̀

et al. 2009

Anal Bioanal Chem

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A zymographic assay of diamine oxidase (DAO, histaminase, EC 1.4.3.6), based on a coupled peroxidase reaction, and its behavior at proteolysis in simulated gastric and intestinal conditions, are described. The DAO activity from a vegetal extract of Lathyrus sativus seedlings was directly determined on sodium dodecyl sulfate polyacrylamide electrophoretic gels containing entrapped horseradish peroxidase, with putrescine as substrate of histaminase and ortho-phenylenediamine as co-substrate of peroxidase. The accumulation of azo-aniline, as peroxidase-catalyzed oxidation product, led to well-defined yellow-brown bands on gels, with intensities corresponding to the enzymatic activity of DAO. After image analysis of gels, a linear dependency of DAO content (Coomassie-stained protein bands) and of its enzymatic activity (zymographic bands) with the concentration of the vegetal extract was obtained. In simulated gastric conditions (pH 1.2, 37 °C), the DAO from the vegetal extract lost its enzymatic activity before 15 min of incubation, either in the presence or absence of pepsin. The protein pattern (Coomassie-stained) revealed that the DAO content from the vegetal extract was kept almost constant in the simulated intestinal fluid (containing pancreatin or not), with a slight diminution in the presence of pancreatic proteases. After 10 h of incubation at 37 °C, the DAO enzymatic activity from the vegetal extract was 44.7% in media without pancreatin and 13.6% in the presence of pancreatin, whereas the purified DAO retained only 4.65% of its initial enzymatic activity in the presence of pancreatin.FigureFigure Zymographic assay of DAO with peroxidase included in polyacrylamide gels

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The effects of diamine oxidase administration on experimental ulcerative colitis in rats

Cited by 8 publications

References 8 publications

Pea Seedling Histaminase as a Novel Therapeutic Approach to Anaphylactic and Inflammatory Disorders

Pea Seedling Histaminase as a Novel Therapeutic Approach to Anaphylactic and Inflammatory Disorders

Histamine in food: is there anything to worry about?

Zymographic assay of plant diamine oxidase on entrapped peroxidase polyacrylamide gel electrophoresis. A study of stability to proteolysis

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