The effects of diabetes mellitus, age, and vitamin E on testicular oxidative stress

Aybek, H.; Aybek, Zafer; Rota, Simin; Şen, Nilay; Akbulut, Metin

doi:10.1016/j.fertnstert.2007.01.101

Cited by 48 publications

(44 citation statements)

References 29 publications

(26 reference statements)

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“…4 . The pathophysiology of these complications are well known but the effects of diabetes on the male reproductive system remains obscure.…”

Section: Discussionmentioning

confidence: 99%

“…Male infertility is a common complication of diabetes. The most frequent effects of DM on the male reproductive system include decreased levels of testosterone, lower testicular weight, abnormal spermatogenesis, alterations in sperm count and motility, and histopathological changes in testis tissue components [2][3][4][5] . Abnormalities in spermatogenesis due to increased apoptosis have been demonstrated in certain studies 2,3,[6][7][8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

“…Aybek et al 4 suggested that the body weight of diabetic men increased and Cai et al 3 suggested that testis weight did not show any change at one month of follow-up but decreased after six months of diabetes.…”

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confidence: 99%

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MAPK immunoreactivity in streptozotocin-induced diabetic rat testis

2014

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PURPOSE:To evaluate the alterations of two mitogen-activated protein kinases (MAPK)s, extracellular signal regulated kinase (ERK) and c-Jun NH2 terminal kinase (JNK), in the testes of male rats with experimental diabetes. METHODS:Twenty males Sprague-Dawley rats were randomly divided into a control group (n=8) and a diabetes group (administration of 40 mg/kg/day streptozotocin (STZ) for five sequential days, n=12). After six weeks, testicular biopsy samples were obtained for light microscopy and immunohistochemical methods. RESULTS:The PCNA (proliferating cell nuclear antigen) index was significantly decreased in the diabetes group (p=0.004) when compared to the control group. Both total (t)-ERK and phosphor (p)-ERK immunoreactivities were significantly decreased in the diabetes group (p=0.004, p<0.001, respectively). The t-JNK immunoreactivity was unchanged in both groups (p=0.125), while p-JNK immunoreactivity was significantly increased in the diabetic group (p=0.002). CONCLUSIONS:The decrease of androgen levels in the course of diabetes may contribute to the decrease of the immunoreactivities of t-ERK and p-ERK. JNK may be activated due to the changes in various cytokines and chemochines that participate in the oxidative stress process of diabetes. Therefore, testicular apoptosis may occur and lead to infertility associated with diabetes.

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“…4 . The pathophysiology of these complications are well known but the effects of diabetes on the male reproductive system remains obscure.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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MAPK immunoreactivity in streptozotocin-induced diabetic rat testis

2014

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“…Diabetes mellitus is associated with endothelial dysfunction, autooxidation, nonenzymatic protein glycation, and activation of polyol pathway with increase in oxidative stress. 3,4 Oxidative stress is characterized by an increased generation of O 2 -derived molecules called reactive oxygen species (ROS) that provoke critical, even irreversible, cell injury. In diabetes mellitus, both exposure to hyperglycemia and functional limitation of hexose monophosphate shunt pathway lead to oxidative stress.…”

Section: Study Of Oxidative Stress Status In Relation Tomentioning

confidence: 99%

Study of Oxidative Stress Status in Relation to Glycemic Index Fluctuations in Type II Diabetes Mellitus Patients

Arafeen¹,

Chatterjee²

2017

Indian Journal of Medical Biochemistry

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Background Oxidative stress is characterized by an increased generation of O2-derived molecules called reactive oxygen species that provoke critical, even irreversible, cell injury. Aim To evaluate oxidative stress status through measurement of malondialdehyde (MDA) and to analyze association of changes in MDA status with respect to fluctuations in glycemic control. Materials and methods A total of 112 subjects, both males and females, aged above 30 years were enrolled for this study, in which 81 had type II diabetes and 31 were without diabetes. Random blood sugar (RBS) was measured by glucose oxidase and peroxidase method. Serum MDA was measured by thiobarbituric acid reactive substances method. Glycated hemoglobin (HbA1c) was measured by ion exchange resin method. Results The MDA and HbA1c levels were increased in diabetics and were statistically significant. In all the studied groups, MDA was positively correlated with RBS and HbA1c. Conclusion and clinical significance The study suggests that MDA should be measured along with routine parameters of disease and the use of redox active antioxidants to tone down MDA levels may be evaluated to contribute in early and improvised clinical management of type II diabetes mellitus and also to delay the development of secondary complications of the disease. How to cite this article Arafeen S, Chatterjee M. Study of Oxidative Stress Status in Relation to Glycemic Index Fluctuations in Type II Diabetes Mellitus Patients. Indian J Med Biochem 2017;21(1):49-53.

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“…DM affects almost all organs and systems with complications such as retinopathy, nephropathy and neuropathy, cardiovascular complications, and ulceration, etc. (2)(3)(4). Thus, diabetes includes a wide variety of heterogeneous diseases.…”

Section: Introductionmentioning

confidence: 99%

New Insight Into Metformin Action: Diabetes, Prostate Cancer, Ion Channels

Karabulut-Bulan¹

2016

Marmara Pharm J

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Diabetes Mellitus is a life-long chronic metabolic disease, requiring continuous follow-up and therapy, it reduces the quality of life of patients with acute and chronic complications, mortality, and its economic burden is high. Cancer is the second cause of death, according to the data from World Health Organization. Prostate cancer is one of the most common cancers in the developed world and the second leading cause of male cancer-related death. As with the other cancer types, metastasis is an essential problem that we are facing and it is not clear whether a tumor will metastasize or not in localized state. It has been reported that there are high levels of voltage-gated sodium channels in metastatic prostate cancer cases. Cancer, ever growing with diabetes, is a major health problem. Studies have shown that diabetic patients have higher cancer rates than those of non-diabetics. Metformin is the drug of choice for the treatment of diabetes. Recently, there are studies in the literature regarding metformin reducing the risk of cancer besides its effect on diabetes This review will explain the possible role of the metformın on the three dimensional relationship of prostate cancer, diabetes and ion channels, and provide a significant contribution to clinical trials.

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The effects of diabetes mellitus, age, and vitamin E on testicular oxidative stress

Cited by 48 publications

References 29 publications

MAPK immunoreactivity in streptozotocin-induced diabetic rat testis

MAPK immunoreactivity in streptozotocin-induced diabetic rat testis

Study of Oxidative Stress Status in Relation to Glycemic Index Fluctuations in Type II Diabetes Mellitus Patients

New Insight Into Metformin Action: Diabetes, Prostate Cancer, Ion Channels

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