The Effects of Dexmedetomidine on Neuromuscular Blockade in Human Volunteers

Talke, Pekka; Caldwell, James E.; Richardson, C. A.; Kirkegaard-Nielsen, Hans; Stafford, M

doi:10.1097/00000539-199903000-00031

Cited by 30 publications

(31 citation statements)

References 19 publications

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“…It can provide muscular relaxation via central pathways without affecting the neuromuscular junction (26). Similarly, we observed the loss of stepping and righting reflexes in rats that received intrathecal dexmedetomidine.…”

Section: Discussionsupporting

confidence: 63%

Intracerebroventricular Application of Dexmedetomidine Produces Antinociception and Does not Cause Neurotoxicity in Rats

Köksal¹,

Karakaya²,

Can³

et al. 2013

Balkan Med J

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Section: Discussionsupporting

confidence: 63%

Intracerebroventricular Application of Dexmedetomidine Produces Antinociception and Does not Cause Neurotoxicity in Rats

Köksal¹,

Karakaya²,

Can³

et al. 2013

Balkan Med J

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“…A study done by Talke PO et al [43] on the effects of Dexmedetomidine on the neuromuscular blockade the authors showed that dexmedetomidine resulted in a more decrease in the muscle force using mechanomyog-raphy. Although these changes were statistically significant, the investigators concluded that they were not clinically relevant.…”

Section: Discussionmentioning

confidence: 99%

Dexmedetomidine vs. Magnesium Sulphate as an Adjuvant to Rocuronium Bromide, and Local Anaesthetic Mixture in Peribulbar Anaesthesia for Viteroretinal Surgery

Mogahed¹,

Nassar²,

Abdullah³

2017

J Anesth Clin Res

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“…DEX, a selective α-2 adrenoceptor agonist, has sedative, analgesic and anxiolytic effects after intravenous administration (43). DEX also produces dose-dependent HR and blood pressure reductions (44,45).…”

Section: Group ------------------------------------------------------mentioning

confidence: 99%

Effect of dexmedetomidine combined with sufentanil on preventing emergence agitation in children receiving sevoflurane anesthesia for cleft palate repair surgery

Luo

Cao

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to observe whether dexmedetomidine (DEX) combined with sufentanil decreased emergence agitation (EA) in children receiving sevoflurane anesthesia for cleft palate repair surgery. Children undergoing elective cleft palate repair surgery were randomly allocated into the DEX + sufentanil group (group DS; n=50) and the normal saline + fentanyl group (group SF; n=50). Patients in group DS were treated with 0.5 µg/kg DEX prior to induction of anesthesia, whereas patients in group SF received an equal volume of normal saline. Sufentanil (0.2 µg/kg) was administered to induce anesthesia, and 30 min before the end of surgery for patients in group DS. Fentanyl (2 µg/kg) was administered at the same time point for patients in group SF. Mean arterial pressure (MAP), heart rate (HR), duration of surgery and anesthesia, and the dosage of remifentanil were assessed. EA score, Pediatric Anesthesia Emergence Delirium (PAED) score and the Children and Infants Postoperative Pain Scale (CHIPPS) score were documented every 15 min in the post-anesthesia care unit (PACU). The number of cases requiring fentanyl (1 µg/kg) and the recovery profile data were analyzed. Compared with group DS (P<0.05) and the baseline (P<0.05), HR and MAP were significantly increased in group SF immediately following tracheal intubation and extubation. Mean values of maximum EA, PAED and CHIPPS scores were significantly reduced in group DS compared with group SF at 0 (P<0.01), 15 (P<0.05), and 30 min (P<0.05) after arrival at PACU. The incidence of EA in group SF was significantly increased compared with group DS (P<0.05). The dosage of remifentanil during the surgery and the number of cases requiring fentanyl (1 µg/kg) in group DS were significantly decreased compared with group SF (P<0.05). The findings of the present study suggested that DEX combined with sufentanil was able to effectively decrease the incidence of EA in children receiving sevoflurane anesthesia for cleft palate repair surgery.

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The Effects of Dexmedetomidine on Neuromuscular Blockade in Human Volunteers

Cited by 30 publications

References 19 publications

Intracerebroventricular Application of Dexmedetomidine Produces Antinociception and Does not Cause Neurotoxicity in Rats

Intracerebroventricular Application of Dexmedetomidine Produces Antinociception and Does not Cause Neurotoxicity in Rats

Dexmedetomidine vs. Magnesium Sulphate as an Adjuvant to Rocuronium Bromide, and Local Anaesthetic Mixture in Peribulbar Anaesthesia for Viteroretinal Surgery

Effect of dexmedetomidine combined with sufentanil on preventing emergence agitation in children receiving sevoflurane anesthesia for cleft palate repair surgery

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