The effects of Danggwisusan on restoration ability in wound induced animal models

Bak, Ji Won; Sim, Boo Yong; Kim, Dong Hee

doi:10.6116/kjh.2014.29.5.55

Cited by 11 publications

(4 citation statements)

References 13 publications

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“…이 시기 동안 통증과 부기 관리, 수술 부위 보호, 관절 강직 방지 등을 목표로 한다 3,5,9,12) . 17,18) . 2단계부터는 기혈의 순환과 발목의 연부조직 회복을 위해 補益의 목적으로 十全大補湯 (甘草 4.0 g, 白茯苓 4.0 g, 白芍藥 4.0 g, 白朮 4.0 g, 熟地黃 4.0 g, 人蔘 4.0 g, 川芎 4.0 g, 黃芪 4.0g, 當歸 4.0 g, 肉桂 4.0 g/첩)을 사용하였다 19) .…”

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The Clinical Effect of Rehabilitation Protocol for Distal Radius Fracture in Korean Medicine: A Report of 3 Cases

Geum

Koh

et al. 2018

J Korean Med Rehabil

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The objective of this study was to propose a rehabilitation protocol for distal radius fracture in Korean Medicine and to report its effectiveness. Three patients who had undergone distal radius fracture were treated using the rehabilitation protocol in Korean Medicine. We estimated the outcome evaluating physical examination findings of the wrist joint, numeric rating scale and quick the Disabilities of the Arm, Shoulder and Hand (DASH) score. After the treatment, we observed that wrist movement, numeric rating scale and quick DASH score were improved. A rehabilitation in Korean Medicine can be effectively used for distal radius fracture patients. The limitation of this study was the insufficient number of cases. Further studies are needed to design a rehabilitation protocol in Korean Medicine.

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Section: 서론»»»unclassified

The Clinical Effect of Rehabilitation Protocol for Distal Radius Fracture in Korean Medicine: A Report of 3 Cases

Geum

Koh

et al. 2018

J Korean Med Rehabil

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“…Previous studies have reported headache relief [5], external injury amelioration [6], fracture healing [7], subcutaneous hematoma amelioration [8], antithrombotic [9], cerebral ischemic injury amelioration [10], allergic purpura amelioration [11], and pain control [12] effects of Danggwisusan.…”

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confidence: 99%

Anti-Inflammatory and Anti-Oxidative Effects of Danggwisusan on Macrophages

2018

J Acupunct Res

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Background: Danggwisusan is a herbal medicine which is used to treat bruises, static blood, external injuries, and somatalgia in Korean medicine. The objectives of this study were to investigate whether Danggwisusan hot aqueous extract had an inhibitory effect upon inflammatory cytokine production and oxidation. Methods: Cytotoxic activity of Danggwisusan extract was examined by 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assay. The amount of nitric oxide produced was measured using Griess reagent. Prostaglandin E2 production was measured using an enzyme immunoassay. Inflammatory cytokines (IL-1β, IL-6 and TNF-α) were measured by an enzyme linked immunosorbent assay. The anti-oxidative effect of Danggwisusan was measured by the 1,1-Diphenyl-2-picryl hydrazyl method. The amount of polyphenol and flavonoid contents were measured by Folin and Ciocalteauea phenol reagent and aluminum nitrate. Results: Danggwisusan hot aqueous extracts did not show significant toxicity at 10, 20, 50, and 100 µg/ mL. At a dose of 100 µg/mL, Danggwisusan hot aqueous extract significantly inhibited nitric oxide and PGE2 production, and significantly reduced IL-1β, IL-6 and TNF-α production. At a dose of 100 µg/mL, 1,1-Diphenyl-2-picryl hydrazyl free radical scavenging capability was over 50%. Conclusion: This study showed that Danggwisusan hot aqueous extract may have anti-inflammatory and anti-oxidative effects on macrophages.

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“…창상 치료에 대한 한의학적 연구로는 托裏消毒飮 4) , 四君子湯 5) , 當歸鬚散 6) , 當歸飮子 7) , 十全大補湯 8) 및 大補湯加味方 9) , 桂枝茯苓丸 10) , 黑蔘 11) , 金銀花 12) 등 경구 투여 약재와 紫雲膏 연고제 13) , 한방좌욕제 14) , 黃耆약침 15) 등 이 있다.…”

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The Effect of Dangguijakyak-san on Wound Healing

Lee,

Woo,

Kim

et al. 2023

J Korean Med Rehabil

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Objectives We evaluated the wound healing effects of Dangguijakyak-san (DJ) using C57BL/6 mice that were generated open wound. Methods The study was conducted with seven C57BL/6 mice assigned to each group, divided into the normal group, control group, vitamin E group, DJ low-dose group, DJ high-dose group. We measured total polyphenol, flavonoid contents, the size of the wound, liver function, pro-inflammatory cytokine activity in serum, inflammation-related proteins, adhesion molecules and chemokine proteins, collagen-related proteins in skin tissue and histopathological changes by H&E and Masson's staining.Results DJ treatment significantly reduced the area of the wound compared to the control group. Also, inflammatory cytokines were reduced and the expression of anti-inflammatory-related factors (interleukin-4 [IL-4] and IL-10) was significantly increased in the DJ treatment group. We identified that DJ treatment inhibits both pathways of inflammation, the mitogen-activated protein kinases and nuclear factor-κB pathway. Moreover, the protein expressions of Sirt1 (sirtuin 1), MCP-1 (monocyte chemoattractant protein 1), ICAM-1 (intercellular adhesion molecule 1), and VCAM-1 (vascular cell adhesion molecule 1) were decreased by DJ administration. Also, the expression of α-smooth muscle actin and collagen type I alpha 1, collagen-related proteins, that help skin recovery was significantly increased in the DJ treatment group. Histopathologically, a relatively thin epithelial layer could be observed in the DJ administration group, as well as an increase in fibroblasts and collagen fibers. Conclusions These data suggest that DJ treatment is effective in wound healing, suppressing inflammatory proteins, increasing skin repair factors and improving histopathological changes caused by wounds.

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The effects of Danggwisusan on restoration ability in wound induced animal models

Cited by 11 publications

References 13 publications

The Clinical Effect of Rehabilitation Protocol for Distal Radius Fracture in Korean Medicine: A Report of 3 Cases

The Clinical Effect of Rehabilitation Protocol for Distal Radius Fracture in Korean Medicine: A Report of 3 Cases

Anti-Inflammatory and Anti-Oxidative Effects of Danggwisusan on Macrophages

The Effect of Dangguijakyak-san on Wound Healing

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