The effects of D-dimer high rates on prognosis and mortality in chronic obstructive respiratory disease

Abstract

Aim:We aim to answer the question of "Can D-dimer be an indicator of prognosis and mortality in COPD exacerbations?" by doing retrospective research on the prognosis and mortality of patients who had high D-dimer levels in COPD exacerbations with no thromboembolism detected. Material and Method: Our research is retrospective and cross-sectional. A total of 115 patients who had applied to our hospital between January 2018 and January 2019 with COPD acute exacerbations and who had higher D-dimer levels detected than the 0.44 mg/L upper limit of our hospital's laboratory are included in this research. All patients have been previously diagnosed with COPD by a pulmonologist and have been undergoing treatment. Patients under the age of 18, patients whose information was not accessible through their files, pregnant patients, patients who have not been diagnosed with COPD by a pulmonologist, patients who had been diagnosed with lung malignancy through pathology, patients where pulmonary embolism was detected through pulmonary CT angiography, patients with renal function test disorder and patients with known renal failure are not included in this study. Results: A total of 115 patients were included in the study. Patients who developed mortality had statistically significant lower levels of OSAS, higher rates of pneumonia, anemia, and liver failure, higher numbers of applications to emergency services in 1 year, higher numbers of hospitalizations due to COPD acute exacerbations in 1 year, higher numbers of intensive care unit admissions due to COPD acute exacerbations in 1 year and lower survival time. In addition, patients who developed mortality had statistically significant lower rates of group B and C and higher rates of group D according to the classification of Global Initiative of Chronic Obstructive Lung Disease (GOLD). Although the D-dimer levels were higher in patients who developed mortality, there were no statistically significant differences between groups. No significant cut-off value for D-dimer was calculated. Conclusion: As a result, although our study has found higher D-dimer levels in patients who develop mortality, these results were not statistically significant.

Relationship between lipid profile and monocyte to highdensity lipoprotein ratio with disease severity in chronic obstructive pulmonary disease patients

“…There is a negative correlation between low FEV1 values and group C and D with advanced COPD. This means that FEV1 values are expected to be significantly lower in groups C and D. When evaluated according to the GOLD 2021 guideline, the more advanced the COPD, the higher the morbidity and mortality is expected according to the combined COPD assessment consisting of symptoms and exacerbations (1,2). COPD is a systemic inflammatory disease and may be associated with many diseases, especially cardiovascular diseases (1).…”