The effects of Cyperus rotundus L. extracts on the longevity of Drosophila melanogaster

Wongchum, Nattapong; Dechakhamphu, Ananya; Ma-ding, Abdulwaris; Khamphaeng, Tistaya; Pinlaor, Somchai; Pinmongkhonkul, Sitthisak; Tanomtong, Alongkoad

doi:10.1016/j.sajb.2022.04.037

Cited by 2 publications

(3 citation statements)

References 66 publications

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“…Some attention has been attracted to the effects of dietary manipulations on the lifespan of D. melanogaster and other animals. [20][21][22][23][24] These previously published studies suggest that dietary induction may be beneficial in extending the lifespan of fruit flies or other animals.…”

Section: Introductionmentioning

confidence: 94%

“…reported that activation of individual AMPs, including statin in D. melanogaster , significantly extended the lifespan of the fruit flies. Some attention has been attracted to the effects of dietary manipulations on the lifespan of D. melanogaster and other animals 20‐24 . These previously published studies suggest that dietary induction may be beneficial in extending the lifespan of fruit flies or other animals.…”

Section: Introductionmentioning

confidence: 99%

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Artemisia argyi extract exerts antioxidant properties and extends the lifespan of Drosophila melanogaster

Yang,

Cao,

Zhang

et al. 2024

J Sci Food Agric

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BACKGROUNDChinese mugwort (Artemisia argyi) possesses extensive pharmacological activities associated with anti‐tumour, antioxidative and anti‐inflammatory effects. The present study aimed to investigate the antioxidant and anti‐ageing effects of A. argyi extract (AAE) on the fruit fly (Drosophila melanogaster) ageing model by detecting antioxidant enzyme activities and the mRNA level of antioxidant genes.RESULTSAAE could significantly lengthen the mean lifespan, 50% survival days, and maximum lifespan of D. melanogaster, especially when the amount of AAE added reached 6.68 mg mL−1, the mean lifespan of both female and male flies increased by 23.74% and 22.30%, respectively, indicating the effective life extension effect of AAE. At the same time, AAE could improve the climbing ability and tolerance to hydrogen peroxide in D. melanogaster. In addition, the addition of AAE effectively increased the activities of copper‐zinc‐containing superoxide dismutase, manganese‐containing superoxide dismutase and catalase in D. melanogaster and reduced the contents of malondialdehyde. Moreover, when reared with diets containing AAE, the expression of antioxidant‐related genes SOD1, SOD2 and CAT was up‐regulated in D. melanogaster and down‐regulated for MTH genes.CONCLUSIONThe study indicates that AAE effectively enhances the antioxidant capacity of D. melanogaster and has potential applications as an antioxidant and anti‐ageing agent in the nutraceutical industry. © 2024 Society of Chemical Industry.

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Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Artemisia argyi extract exerts antioxidant properties and extends the lifespan of Drosophila melanogaster

Yang,

Cao,

Zhang

et al. 2024

J Sci Food Agric

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“…Recently reports have revealed that the hydroethanolic extract of C. rotundus enhances sexual behavior and fitness in Drosophila [24]. The supplementation of Drosophila with this extract resulted in an increase in lifespan and a decrease in oxidative stress-induced mortality [25]. In a Drosophila obesity model, supplementation with C. rotundus extract exhibited to extend lifespan in the presence of high-fat diet-induced mortality [26].…”

Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Evaluation for Antioxidant and Anti-Diabetic Properties of Cyperus rotundus L. Kombucha

Dechakhamphu,

Wongchum,

Chumroenphat

et al. 2023

Foods

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Cyperus rotundus L. exhibits promising potential for the development of functional foods due to its documented pharmacological and biological activities. This study investigated the antioxidant and anti-diabetic properties of C. rotundus kombucha. The results demonstrated potent antioxidant activity with an IC50 value of 76.7 ± 9.6 µL/mL for the DPPH assay and 314.2 ± 16.9 µL/mL for the ABTS assay. Additionally, the kombucha demonstrated alpha-glucosidase inhibitory with an IC50 value of 142.7 ± 5.2 µL/mL. This in vitro antioxidant potential was further validated in vivo using Drosophila. Drosophila fed a high-sugar diet and supplemented with pure kombucha revealed significant increases in DPPH and ABTS free radical scavenging activity. Drosophila on a high-sugar diet supplemented with varying kombucha concentrations manifested enhanced resistance to oxidative stresses induced by H2O2 and paraquat. Concurrently, there was a notable decline in lipid peroxidation levels. Additionally, significant upregulations in CAT, SOD1, and SOD2 activities were observed when the high-sugar diet was supplemented with kombucha. Furthermore, in vivo assessments using Drosophila demonstrated significant reductions in alpha-glucosidase activity when fed with kombucha (reduced by 34.04%, 13.79%, and 11.60% when treated with 100%, 40%, and 10% kombucha, respectively). A comprehensive GC-MS and HPLC analysis of C. rotundus kombucha detected the presence of antioxidative and anti-glucosidase compounds. In conclusion, C. rotundus kombucha exhibits considerable antioxidant and anti-diabetic properties, demonstrating its potential as a beneficial beverage for health promotion.

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The effects of Cyperus rotundus L. extracts on the longevity of Drosophila melanogaster

Cited by 2 publications

References 66 publications

Artemisia argyi extract exerts antioxidant properties and extends the lifespan of Drosophila melanogaster

Artemisia argyi extract exerts antioxidant properties and extends the lifespan of Drosophila melanogaster

In Vitro and In Vivo Evaluation for Antioxidant and Anti-Diabetic Properties of Cyperus rotundus L. Kombucha

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