The effects of curcumin supplementation on oxidative stress, Sirtuin-1 and peroxisome proliferator activated receptor γ coactivator 1α gene expression in polycystic ovarian syndrome (PCOS) patients: A randomized placebo-controlled clinical trial

Heshmati, Javad; Golab, Fereshteh; Morvaridzadeh, Mojgan; Potter, Eric; Akbari‐Fakhrabadi, Maryam; Farsi, Farnaz; Tanbakooei, Sara; Shidfar, Farzad

doi:10.1016/j.dsx.2020.01.002

Cited by 84 publications

(64 citation statements)

References 41 publications

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“…Pancreatic β-cells show weak antioxidant enzyme defense, and oxidative stress has been proved to be an important feature for the pathogenesis and development of type 2 diabetes (T2DM) [ 33 – 35 ]. Besides, some indirect evidence also suggested that appropriate antioxidant supplementation can regulate lipid metabolism and improve insulin sensitivity [ 36 – 38 ]. Evidence suggested that elevated glucose levels can induce reactive oxygen species generation on islet β-cells, which in turn cause oxidative stress and β-cells dysfunction, and then lead to IR and T2DM [ 33 – 35 ].…”

Section: Discussionmentioning

confidence: 99%

Association between triglyceride-glucose index and risk of incident diabetes: a secondary analysis based on a Chinese cohort study

Tien

et al. 2020

Lipids Health Dis

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Background Recent studies have suggested the triglyceride-glucose index (TyG index) may serve as a suitable substitute for insulin resistance. However, evidence for the relationship between TyG index and risk of diabetes remains limited. This study sought to explore the association of baseline TyG index with risk of developing diabetes in Chinese adults. Methods This retrospective cohort study was conducted using data from the health screening program in China. A total of 201,298 non-diabetic individuals were included. TyG index was calculated as Ln [fasting plasma glucose (mg/dL) × fasting triglyceride level (mg/dL) / 2]. Diabetes was defined as fasting plasma glucose ≥126 mg/dL and/or self-reported diabetes. Cox proportion-hazard model was employed to evaluate the independent impact of baseline TyG index on future diabetes risk. Sensitivity and subgroup analyses were implemented to verify the reliability of results. Notably, data were downloaded from the DATADRYAD website, and used only for secondary analyses. Results During an average follow-up of 3.12 years, among 201,298 individuals aged ≥20 years, 3389 subjects developed diabetes. After adjusting for potential confounders, elevated TyG index were independently correlated with greater risk of incident diabetes (hazard ratio (HR), 3.34; 95% confidence interval (CI), 3.11–3.60). Compared with the lowest quartile (Q1), increasing TyG index (Q2, Q3, and Q4) was related to increased HR estimates of incident diabetes [HR (95% CI), 1.83 (1.49–2.26); 3.29 (2.70–4.01), and 6.26 (5.15–7.60), respectively]. Moreover, a nonlinear relationship was observed between TyG index and risk of diabetes and the slope of the curve increased accompanying the rise of TyG index. Subgroup analysis revealed the positive association was stronger among subjects with age < 40 years, body mass index ≥18.5 kg/m2 and < 24 kg/m2, or systolic blood pressure < 140 mmHg, or in females. Conclusions Elevated TyG index is independently correlated with increased risk of incident diabetes in Chinese adults, indicating it may represent a reliable predictor of diabetes in high-risk populations.

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Section: Discussionmentioning

confidence: 99%

Association between triglyceride-glucose index and risk of incident diabetes: a secondary analysis based on a Chinese cohort study

Tien

et al. 2020

Lipids Health Dis

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“…Studies have found that, with increases in weight, abnormal genes such as the Wnt signalling pathway, oxidative stress, and inflammation in adipose tissue of PCOS patients are abnormal [ 37 ], suggesting that obesity participates in the pathogenesis of PCOS [ 38 ], triggers metabolic and reproductive disorders, and may also cause glycolipid metabolism, hyperandrogenaemia, menstrual disorders, infertility, and comorbidities related to polycystic ovary syndrome [ 39 ]. Furthermore, we also noticed that many features and complications of polycystic ovary syndrome (PCOS) can trigger oxidative stress and increase insulin resistance index [ 40 , 41 ]. Obese women with PCOS show lower ISOGTT and higher LH to stimulate androgen secretion, triggering insulin resistance and excessive androgens [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Metformin on Polycystic Ovary Syndrome in Overweight Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Guan

Wang

et al. 2020

International Journal of Endocrinology

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Objective. Metformin is an important component of PCOS treatment. At present, the effect of metformin in overweight women with PCOS has not been evaluated. Therefore, we conducted a systematic review to assess the effects of metformin in overweight women with PCOS and to analyze the effects of metformin in overweight women with PCOS. Methods. We searched the PubMed, Cochrane Library, Embase, CNKI, VIP, and Wanfang databases for studies published before March 2020. Randomized controlled trials were identified to study the effects of metformin in overweight women with PCOS. Data from studies including body mass index (BMI), waist circumference (WC), follicle-stimulating hormone (FSH), homeostasis model assessment of insulin resistance (HOMA-IR), luteinizing hormone (LH), sex hormone-binding globulin (SHBG), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, total cholesterol (TC), triglycerides (TG), fasting blood glucose (FBG), fasting insulin, testosterone, and androstenedione were pooled. Qualified trials were selected, and methodological quality was strictly assessed. Two reviewers chose the studies independently of each other. Results. Twelve trials were included. The intervention group and the control group had significant differences in the changes in body mass index (BMI) (WMD = −1.25, 95% CI (−1.60, −0.91), p<0.00001) and waist circumference (WC) (WMD = −1.41, 95% CI (−2.46, −0.37), p=0.008) after metformin. The comprehensive results show that, in all studies, overweight women with polycystic ovary syndrome treated with metformin had significantly improved endocrine and metabolic indicators, including testosterone, follicle-stimulating hormone, luteinizing hormone, and low-density lipoprotein cholesterol. However, metformin did not regulate the secretion indexes of fasting insulin, homeostasis model assessment of insulin resistance, sex hormone-binding globulin, high-density lipoprotein cholesterol, total cholesterol, triglycerides, fasting blood glucose, and androstenedione. Conclusions. Compared with control interventions, metformin appears to be an effective intervention for overweight women with PCOS.

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“…Dyslipidemia primarily occurs in obese individuals due to the excessive accumulation of fat in the adipose tissues [ 15 ]. Several studies have shown that metabolism of fatty acids and glucose, along with insulin sensitivity, are both influenced by nutritional and genetic factors [ 16 , 17 ]. It has been well established that both obesity and dyslipidemia were considered traditional risk factors for prediabetes because these two conditions can increase peripheral tissue IR [ 18 – 21 ].…”

Section: Introductionmentioning

confidence: 99%

Elevated triglyceride-glucose (TyG) index predicts incidence of Prediabetes: a prospective cohort study in China

et al. 2020

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Background Prediabetes has become a pandemic. This study aimed to identify a better predictor for the incidence of prediabetes, which we hypothesize to be the triglyceride-glucose (TyG) index, a simplified insulin resistance index. We compared its predictive value with the other common risk factors of prediabetes. Methods The participants of this analysis were derived from the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal (REACTION) study. A total of 4543 participants without initial prediabetes or diabetes were followed up for 3.25 years. Using multivariate logistic regression model, the associations between baseline obesity, lipid profiles and non-insulin-based insulin resistance indices with the incidence of prediabetes were analyzed. To assess which is better predictor for the incidence of prediabetes, the area under curves (AUCs) calculated from the receiver operating characteristic curve analyses were used to evaluate and compare with the predictive value of the different indices. Results During the 3.25 years, 1071 out of the 4543 participants developed prediabetes. Using the logistic regression analysis adjusted for some potential confounders, the risk of incidence of prediabetes increased 1.38 (1.28–1.48) fold for each 1–SD increment of TyG index. The predictive ability (assessed by AUCs) of TyG index for predicting prediabetes was 0.60 (0.58–0.62), which was superior to the indices of obesity, lipid profiles and other non-insulin-based insulin resistance indices. Although the predictive ability of the TyG index was overall similar to fasting plasma glucose (FPG) (P = 0.4340), TyG index trended higher than FPG in females (0.62 (0.59–0.64) vs. 0.59 (0.57–0.61), P = 0.0872) and obese subjects (0.59 (0.57–0.62) vs. 0.57 (0.54–0.59), P = 0.1313). TyG index had superior predictive ability for the prediabetic phenotype with isolated impaired glucose tolerance compared with FPG (P < 0.05) and other indices. Furthermore, TyG index significantly improved the C statistic (0.62 (0.60–0.64)), integrated discrimination improvement (1.89% (1.44–2.33%)) and net reclassification index (28.76% (21.84–35.67%)) of conventional model in predicting prediabetes than other indices. Conclusions TyG could be a potential predictor to identify the high risk individuals of prediabetes.

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The effects of curcumin supplementation on oxidative stress, Sirtuin-1 and peroxisome proliferator activated receptor γ coactivator 1α gene expression in polycystic ovarian syndrome (PCOS) patients: A randomized placebo-controlled clinical trial

Cited by 84 publications

References 41 publications

Association between triglyceride-glucose index and risk of incident diabetes: a secondary analysis based on a Chinese cohort study

Association between triglyceride-glucose index and risk of incident diabetes: a secondary analysis based on a Chinese cohort study

The Effect of Metformin on Polycystic Ovary Syndrome in Overweight Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Elevated triglyceride-glucose (TyG) index predicts incidence of Prediabetes: a prospective cohort study in China

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