The effects of curcumin supplementation on glycemic status, lipid profile and hs-CRP levels in overweight/obese women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled clinical trial

Sohaei, Sara; Amani, Reza; Tarrahi, Mohammad Javad; Tehrani, Hatav Ghasemi

doi:10.1016/j.ctim.2019.102201

Cited by 76 publications

(89 citation statements)

References 58 publications

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“…Asadi et al [49] used a nano-curcumin preparation and found a decrease in WC, glycemia, weight, and BMI compared to placebo. Improvement in glycemia was also found by Sohaei et al [50] in polycystic ovary syndrome women.…”

Section: Alt: Alaninesupporting

confidence: 74%

The Effects of Curcuma longa in Insulin Resistance

Salzedas

Batista

Barbalho³

2020

EJMP

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Background: Curcumin is seen as an anti-hyperglycemic agent that acts by improving the expression of glucose transporters. It is also related to the reduction of glycosylated hemoglobin, improvement of insulin sensitivity, plasma lipids, and blood pressure. Aim: The purpose of this article is to review the effects of Curcuma longa in insulin resistance. Methodology: PUBMED and EMBASE databases were searched, and PRISMA (Preferred Reporting Items for a Systematic Review and Meta-analysis) guidelines were followed to build the review. Results: Nineteen Randomized Clinical Trials (RCTs) met the inclusion criteria and were described according to PICO (Population, Intervention, Comparison, and Outcomes). Conclusion: Curcumin could be considered in the therapeutic approach of patients with Insulin Resistance, once it is related to the reduction of oxidative stress, inflammation, serum fasting blood glucose, HOMA-IR, blood pressure, serum lipids, and liver transaminases. However, the results depend on the dose, intervention time, and formulation of the compound.Insulin resistance

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Section: Alt: Alaninesupporting

confidence: 74%

The Effects of Curcuma longa in Insulin Resistance

Salzedas

Batista

Barbalho³

2020

EJMP

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“…Another study showed that the daily ingestion of 2100 mg turmeric powder for eight weeks resulted in a reduction in body weight, low density lipoprotein-cholesterol (LDL-c), and TG levels, with no significant effects on glycemia, CRP, and HbA1c, in hyperlipidemic T2D patients [ 44 ]. In obese women with polycystic ovary syndrome (PCOS), 1000 mg/day curcumin supplementation (500 mg twice daily: 70–80% curcumin, 15–20% demethoxycurcumin and 2.5–6.5% bisdemethoxycurcumin) for six weeks improved serum insulin and the Quantitative Insulin Sensitivity Check Index [ 45 ]. A recent meta-analysis reported that curcumin intake was associated with reduced body mass index (BMI), body weight, body fat, leptin value, and increased adiponectin levels in patients with metabolic syndrome and related disorders [ 46 ].…”

Section: Role Of Curcumin In Pregnancymentioning

confidence: 99%

Curcumin: Could This Compound Be Useful in Pregnancy and Pregnancy-Related Complications?

et al. 2020

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Curcumin, the main polyphenol contained in turmeric root (Curcuma longa), has played a significant role in medicine for centuries. The growing interest in plant-derived substances has led to increased consumption of them also in pregnancy. The pleiotropic and multi-targeting actions of curcumin have made it very attractive as a health-promoting compound. In spite of the beneficial effects observed in various chronic diseases in humans, limited and fragmentary information is currently available about curcumin’s effects on pregnancy and pregnancy-related complications. It is known that immune-metabolic alterations occurring during pregnancy have consequences on both maternal and fetal tissues, leading to short- and long-term complications. The reported anti-inflammatory, antioxidant, antitoxicant, neuroprotective, immunomodulatory, antiapoptotic, antiangiogenic, anti-hypertensive, and antidiabetic properties of curcumin appear to be encouraging, not only for the management of pregnancy-related disorders, including gestational diabetes mellitus (GDM), preeclampsia (PE), depression, preterm birth, and fetal growth disorders but also to contrast damage induced by natural and chemical toxic agents. The current review summarizes the latest data, mostly obtained from animal models and in vitro studies, on the impact of curcumin on the molecular mechanisms involved in pregnancy pathophysiology, with the aim to shed light on the possible beneficial and/or adverse effects of curcumin on pregnancy outcomes.

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“…Curcuma, Pueraria, and cinnamon have been explored to have strong anti-hyperinsulinemia, anti-hyperlipidemia, and antioxidant properties. Besides adjusted oxidative stress, Curcuma had remarkable decreased effects on BMI, FBG, serum insulin, TC, and low-density lipoprotein cholesterol (LDL-C) [ 84 , 124 , 125 ]. Using Curcuma along with metformin could cause a significant reduction in WHR and HOMA-IR in addition to a remarkable advance in glucose disposal rate (GDR) [ 84 , 85 , 125 ].…”

Section: The Utilization Of Herbal Medicine In Women With Pcosmentioning

confidence: 99%

The Effects of Traditional Chinese Medicine-Associated Complementary and Alternative Medicine on Women with Polycystic Ovary Syndrome

Shen

Jin

Pan

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Polycystic ovary syndrome (PCOS) is a touchy clinical and public health problem worldwide, which adversely affects women’s health and health-related comorbidities for lifetime, and represents a tremendous burden for both the family of the patient and for society. According to the diagnostic criteria used and the population studied, the prevalence rate of PCOS is between 6% and 21%. However, current conventional modern medicines for PCOS are only moderately effective at controlling the signs and symptoms, while they are not thoroughly able to prevent complications. Therefore, many patients have turned to complementary and alternative medical (CAM) treatments. CAM use is wide spread among patients with PCOS, and more than 70% of patients use CAM at one point during their diseases. The patients’ primary motivations include dissatisfaction with available medications, perceive higher risk of drug side effects and crushing health burden and economic costs, desire for symptom relief, pursuit of shortening the course of disease, and the belief that CAM therapy is in accordance with the patients’ values and beliefs. At present, several CAM methods have been used in women with PCOS, which has achieved obvious effects. However, biologically plausible mechanisms of the action of traditional Chinese medicine- (TCM-) associated CAM for PCOS have not been systematically reviewed. This review briefly summarizes the current progress of the impact of herbal medicine on the outcomes of PCOS and introduces the mechanisms.

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The effects of curcumin supplementation on glycemic status, lipid profile and hs-CRP levels in overweight/obese women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled clinical trial

Cited by 76 publications

References 58 publications

The Effects of Curcuma longa in Insulin Resistance

The Effects of Curcuma longa in Insulin Resistance

Curcumin: Could This Compound Be Useful in Pregnancy and Pregnancy-Related Complications?

The Effects of Traditional Chinese Medicine-Associated Complementary and Alternative Medicine on Women with Polycystic Ovary Syndrome

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